LEADER 03208nam 2200577 a 450 001 9910737299003321 005 20200520144314.0 010 $a1-299-40812-5 010 $a94-007-5881-2 024 7 $a10.1007/978-94-007-5881-0 035 $a(CKB)2670000000338261 035 $a(EBL)1083670 035 $a(OCoLC)828302722 035 $a(SSID)ssj0000870694 035 $a(PQKBManifestationID)11499159 035 $a(PQKBTitleCode)TC0000870694 035 $a(PQKBWorkID)10819337 035 $a(PQKB)11469098 035 $a(DE-He213)978-94-007-5881-0 035 $a(MiAaPQ)EBC1083670 035 $a(PPN)168341956 035 $a(EXLCZ)992670000000338261 100 $a20130123d2013 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aCytochrome P450 2E1 $eits role in disease and drug metabolism /$fAparajita Dey, editor 205 $a1st ed. 2013. 210 $aNew York $cSpringer$d2013 215 $a1 online resource (267 p.) 225 0$aSub-cellular biochemistry,$x0306-0225 ;$vv. 67 300 $aDescription based upon print version of record. 311 $a94-017-8202-4 311 $a94-007-5880-4 320 $aIncludes bibliographical references and index. 327 $aCytochrome P450 2E1 and its clinical aspects -- Nrf2 and antioxidant defense against CYP2E1 toxicity -- The role of Cytochrome P-4502E1 in ethanol-mediated carcinogenesis -- The Importance of CYP2E1 in the pathogenesis of alcoholic liver disease and drug toxicity and the role of the proteasome -- Relevance of CYP2E1 to non-alcoholic fatty liver disease -- CYP2E1-catalyzed alcohol metabolism -- CYP2E1, oxidative stress, post-translational modifications and  lipid metabolism -- The role of CYP2E1 in alcohol metabolism and sensitivity in the central nervous system. 330 $aThe book deals with various clinical aspects of cytochrome P450 2E1 (CYP2E1), which is a potent source for oxidative stress. Oxidative stress is critical for pathogenesis of diseases and CYP2E1 is a major contributor for oxidative stress. Several clinical disorders are associated with changes in regulation of CYP2E1 and the consequent abnormalities, which include alcoholic liver disease, alcoholic pancreatitis, carcinogenesis, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, obesity, hepatitis C virus infection, reproductive organ toxicity, hepatocellular and cholestatic liver cirrhosis, inhibition of bone repair, cross-tolerance in smokers and people treated with nicotine, disorders of the central nervous system, changes in metabolism of protoxicants in the circulatory system and susceptibility to human papillomavirus infection. Hence, CYP2E1 emerges as a new and potent player in aggravating injury and furthering disease complications. 410 0$aSubcellular Biochemistry,$x0306-0225 ;$v67 606 $aCytochrome P-450 615 0$aCytochrome P-450. 676 $a572.791 701 $aDey$b Aparajita$01750364 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910737299003321 996 $aCytochrome P450 2E1$94184988 997 $aUNINA