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Assessment of alternative treatment strategies for chronic genotype 1 hepatitis C / / Paul G. Barnett [and nine others] editors



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Autore: Goldhaber-Fiebert Jeremy D. Visualizza persona
Titolo: Assessment of alternative treatment strategies for chronic genotype 1 hepatitis C / / Paul G. Barnett [and nine others] editors Visualizza cluster
Pubblicazione: Washington (DC) : , : Department of Veterans Affairs, , [2013]
©2013
Descrizione fisica: 1 online resource (iii, 37 pages) : illustrations
Disciplina: 616.925061
Soggetto topico: Antiviral agents
Hepatitis C virus
Soggetto geografico: United States
Soggetto genere / forma: Technical reports.
Persona (resp. second.): BarnettPaul G.
Note generali: "Evidence-based synthesis program."
"March 2013."
Nota di bibliografia: Includes bibliographical references.
Sommario/riassunto: There is great potential to improve health outcomes for Veterans and other patients with chronic genotype 1 (GT1) Hepatitis C (HCV) infections through the use of newly-available triple combination therapies that include directly acting antivirals (DAA) along with recently developed patient genotyping (IL-28B) which is predictive of HCV treatment response. Chronic GT1 HCV infections have been historically difficult to treat, with low cure rates on standard two drug therapy (Pegylated Interferon + Ribavirin), high rates of side-effects and treatment discontinuation, and low rates of uptake. Recently, FDA approved two DAAs (boceprevir and telaprevir). Used in combination with standard two drug therapy as triple therapy, these DAAs show higher rates of sustained viral response, though they are also more costly and have more severe side-effect profiles. IL-28B genotyping can help to identify patients least likely to respond to standard therapy and hence who stand to benefit the most from triple therapy and for whom, therefore, the increased risks of side-effects may be most justified.
Titolo autorizzato: Assessment of alternative treatment strategies for chronic genotype 1 hepatitis C  Visualizza cluster
Formato: Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione: Inglese
Record Nr.: 9910717367103321
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