02971nam 2200505 450 991071736710332120221104070223.0(CKB)3790000000310888(NjHacI)993790000000310888(OCoLC)862321793(OCoLC)878436113(OCoLC)1117874724(EXLCZ)99379000000031088820221104d2013 uy 0engur|||||||||||txtrdacontentcrdamediacrrdacarrierAssessment of alternative treatment strategies for chronic genotype 1 hepatitis C /Paul G. Barnett [and nine others] editorsWashington (DC) :Department of Veterans Affairs,[2013]©20131 online resource (iii, 37 pages) illustrations"Evidence-based synthesis program.""March 2013."Includes bibliographical references.There is great potential to improve health outcomes for Veterans and other patients with chronic genotype 1 (GT1) Hepatitis C (HCV) infections through the use of newly-available triple combination therapies that include directly acting antivirals (DAA) along with recently developed patient genotyping (IL-28B) which is predictive of HCV treatment response. Chronic GT1 HCV infections have been historically difficult to treat, with low cure rates on standard two drug therapy (Pegylated Interferon + Ribavirin), high rates of side-effects and treatment discontinuation, and low rates of uptake. Recently, FDA approved two DAAs (boceprevir and telaprevir). Used in combination with standard two drug therapy as triple therapy, these DAAs show higher rates of sustained viral response, though they are also more costly and have more severe side-effect profiles. IL-28B genotyping can help to identify patients least likely to respond to standard therapy and hence who stand to benefit the most from triple therapy and for whom, therefore, the increased risks of side-effects may be most justified.Antiviral agentsHepatitis C virusUnited StatesfastTechnical reports.lcgftAntiviral agents.Hepatitis C virus.616.925061Goldhaber-Fiebert Jeremy D.1412326Barnett Paul G.United States.Department of Veterans Affairs.Health Services Research and Development Service,West Los Angeles VA Medical Center.Evidence-Based Synthesis Program Center.VA Health Economics Resource Center (U.S.)Quality Enhancement Research Initiative (U.S.)Evidence-based Synthesis Program (U.S.)NjHacINjHaclBOOK9910717367103321Assessment of alternative treatment strategies for chronic genotype 1 hepatitis C3505467UNINA