Pediatric and adolescent andrology / / Carlo Foresta, Daniele Gianfrilli, editors

• Pubblicazione: Cham, Switzerland : , : Springer, , [2021]; ©2021
• Descrizione fisica: 1 online resource (282 pages)
• Disciplina: 616.65
• Soggetto topico: Andrology; Pediatric andrology; Andrologia; Urologia pediàtrica
• Soggetto genere / forma: Llibres electrònics
• Persona (resp. second.): ForestaCarlo; GianfrilliDaniele
• Nota di contenuto: Intro -- Preface -- Contents -- 1: Genetics and Alterations in the Development of Male Reproductive System: Diagnosis and Clinical Management -- 1.1 Physiology of Male Sex Determination and Sexual Differentiation -- 1.2 Pathophysiology of Male Sex Determination and Sexual Differentiation -- 1.3 Clinical Manifestations of Mutations in Genes Involved in Sex Determination -- 1.3.1 46,XX Testicular/Ovo-Testicular DSD -- 1.3.2 46,XY Gonadal Dysgenesis/Ovo-Testicular DSD -- 1.4 Clinical Manifestations of Mutations in Genes Involved in Sexual Differentiation -- 1.4.1 Disorders of Androgen Biosynthesis: Reduced Androgen Levels -- 1.4.2 Disorders of Androgen Biosynthesis: Androgen Excess -- 1.4.3 Disorders of Testosterone Metabolism -- 1.4.4 Disorders of Androgen Action -- 1.4.5 Disruption of Leydig Cell Differentiation -- 1.4.6 Persistent Müllerian Duct Syndrome (PMDS) -- 1.5 Diagnosis and Clinical Management of DSD Patients -- 1.6 Conclusions -- References -- 2: Impact of Endocrine Disruptors on Male Sexual Development -- 2.1 Introduction -- 2.2 Bisphenol A -- 2.3 Phthalates -- 2.4 Perfluoroalkyl Compounds -- 2.5 Conclusions -- References -- 3: From Genetics to Epigenetics: New Insights into Male Reproduction -- 3.1 Introduction (Genetic Versus Epigenetic Cause of Male Infertility) -- 3.2 Molecular Basis of Epigenetics -- 3.3 Epigenetics and Human Spermatogenesis -- 3.4 Factors Affecting Epigenetic Modifications in Sperm -- 3.4.1 Lifestyle Factors (Diet, Exercise, Obesity, Smoke) -- 3.4.2 Environmental Factors (Endocrine Disruptors, Psychological Stress, Pollution, Heat, Toxins, Ionizing Radiation) -- 3.5 Transgenerational Inheritance -- 3.6 Assisted Reproductive Technique (ART) -- 3.7 Conclusions -- References -- 4: Medical and Surgical Treatment of Congenital Anomalies of Male Genital Tract -- 4.1 Introduction. ; 4.2 Disorders of Male Sexual Development (DSD) -- 4.2.1 DSD Due to Androgen Biosynthesis Problems or Actions -- 4.2.2 Diagnosis of DSD -- 4.2.3 Treatment -- 4.2.3.1 Medical Therapy -- Puberty Induction in Phenotypic Males with 46,XY Disorders of Sex Development -- Puberty Induction in Phenotypic Females with 46,XY Disorders of Sex Development -- 4.2.3.2 Surgical Therapy -- Phallic Reconstruction -- Feminizing Genitoplasty -- 4.3 Isolated Cryptorchidism -- 4.3.1 Pathophysiology -- 4.3.2 Surgical Treatment -- 4.3.3 Medical Treatment -- 4.4 Isolated Hypospadias -- 4.4.1 Treatment -- 4.5 Anorchia -- 4.6 Congenital Penile Curvature -- References -- 5: Disorders of Pubertal Development: From Hypogonadotropic Hypogonadism to Constitutional Delay of Puberty -- 5.1 Background -- 5.2 Normal Puberty -- 5.2.1 Physiology -- 5.2.2 External Pubertal Development -- 5.2.3 Onset of Puberty -- 5.3 Normal Variants of Puberty -- 5.3.1 Delayed Puberty -- 5.4 Disorders of Puberty -- 5.4.1 Incomplete/Absent Puberty -- 5.5 Functional Hypogonadotropic Hypogonadism -- 5.5.1 Nutritional Hypogonadotropic Hypogonadism -- 5.5.2 Psychosocial Factors -- 5.5.3 Clinical Impact of Functional Hypogonadotropic Hypogonadism -- 5.5.4 Assessment of Suspected Functional Hypogonadotropic Hypogonadism -- 5.5.5 Management of Functional Hypogonadotropic Hypogonadism -- 5.6 Congenital Hypogonadotropic Hypogonadism -- 5.7 Acquired Hypogonadotropic Hypogonadism -- 5.7.1 Pituitary Tumours -- 5.7.2 Pubertal Effects of Treatment for Childhood Malignancies -- 5.8 Management of Hypogonadotropic Hypogonadism -- 5.9 Pubertal Induction -- 5.9.1 Testosterone Esters -- 5.9.2 Other Options -- 5.9.3 Side Effects -- 5.10 Conclusion -- References -- 6: Disorders of Pubertal Development: Precocious Puberty -- 6.1 Introduction -- 6.2 Central Precocious Puberty. ; 6.2.1 Causes -- 6.2.2 Evaluation -- 6.2.3 Medical History and Physical Examination -- 6.2.4 Bone Age -- 6.2.5 Laboratory evaluation -- 6.2.6 Imaging -- 6.2.7 Treatment -- 6.3 Peripheral Precocious Puberty -- 6.3.1 Causes -- 6.4 Evaluation -- 6.4.1 Medical History and Physical Examination -- 6.4.2 Bone Age -- 6.4.3 Laboratory Evaluation -- 6.4.4 Imaging -- 6.4.4.1 Treatment -- 6.5 Benign or Nonprogressive Pubertal Variants -- References -- 7: Clinical Management and Treatment of Varicocele in the Adolescence -- 7.1 Introduction -- 7.2 Pathogenesis of Testicular Damage -- 7.3 Diagnostic Evaluation -- 7.4 Management -- 7.5 Treatment Options -- 7.6 Established Guidelines -- 7.7 Conclusions and Authors' Recommendations -- References -- 8: Congenital Causes of Hypergonadotropic Hypogonadism: Anorchia and Klinefelter Syndrome -- 8.1 Anorchia -- 8.1.1 Etiology and Diagnosis -- 8.1.2 Clinical and Biochemical Presentation -- 8.2 Klinefelter Syndrome -- 8.2.1 Etiology and Diagnosis -- 8.2.2 Genetics -- 8.2.3 Clinical and Biochemical Presentation -- 8.2.3.1 Infancy -- 8.2.3.2 Prepubertal Boys -- 8.2.3.3 Puberty -- 8.2.3.4 Adulthood -- 8.2.4 Testicular Histology -- 8.2.5 Fertility -- 8.2.6 Neurodevelopmental and Psychosocial Presentation -- 8.2.7 Gender Identity, Sexuality, and Sexual Function -- 8.2.8 Comorbidities -- 8.3 Testosterone Treatment -- 8.3.1 Anorchia -- 8.3.2 Klinefelter Syndrome -- References -- 9: Acquired Testicular Disorders -- 9.1 Testicular Trauma -- 9.1.1 Epidemiology -- 9.1.2 Etiology and Pathophysiology -- 9.1.3 Clinical Presentation -- 9.1.4 Diagnosis -- 9.1.5 Management and Treatment -- 9.2 Testicular Torsion -- 9.2.1 Epidemiology -- 9.2.2 Etiology and Pathophysiology -- 9.2.3 Clinical Presentation -- 9.2.4 Diagnosis -- 9.2.5 Complications -- 9.2.6 Management and Treatment. ; 9.3 Orchitis -- 9.3.1 Epidemiology and Classification -- 9.3.2 Etiology and Pathophysiology -- 9.3.2.1 Infectious Epididymo-Orchitis -- 9.3.2.2 Noninfectious Epididymo-Orchitis -- 9.3.3 Clinical Presentation -- 9.3.4 Diagnosis -- 9.3.4.1 History and Physical Examination -- 9.3.4.2 Diagnostic Testing -- 9.3.5 Complications -- 9.3.6 Management and Treatment -- 9.3.7 Follow-Up -- 9.4 Testicular Iatrogenic Damage -- 9.4.1 CT-Associated Testicular Damage -- 9.4.2 SCT-Related Testicular Damage -- 9.4.3 RT-Associated Testicular Damage -- 9.4.4 Endocrine Evaluation in Cancer Survivors -- 9.4.5 Other Causes of Iatrogenic Testicular Damage -- 9.5 Conclusions -- References -- 10: Risk Factors Affecting Puberty: Environment, Obesity, and Lifestyles -- 10.1 Introduction -- 10.2 Risk Factors Affecting Puberty: Environment, Obesity, and Lifestyles -- 10.3 Environment -- 10.4 Obesity -- 10.5 Lifestyles -- 10.6 Negative Energy Balance: Severe Malnutrition and Vigorous Physical Activity -- 10.7 Conclusions -- References -- 11: Sexually Transmitted Infections and Risk Behaviors in the Adolescence -- 11.1 Introduction -- 11.2 Epidemiology -- 11.3 Risk Factors for STIs in Adolescents -- 11.4 Screening for STIs in Adolescents -- 11.4.1 Investigation of Sexual History -- 11.4.2 Physical Examination -- 11.5 Prevention of HIV Risk: Preexposure Prophylaxis -- 11.6 Confidentiality in Adolescent Patient-Physician Relationship -- References -- 12: Sexual Disorders in Adolescents and Young Adults -- 12.1 Introduction -- 12.2 Sexual Dysfunctions in Adolescence -- 12.3 Sexual Dysfunctions in Young Adults -- 12.4 Internet-Related Sexual Disorders in Youths -- 12.5 Sex Education -- 12.6 Conclusions -- References -- 13: Diagnosis and Management of Testicular Tumours in Children and Adolescents -- 13.1 General Introduction. ; 13.2 Histopathology, Biological Features, and Diagnostic Markers -- 13.2.1 Testicular Germ Cell Tumours -- 13.2.1.1 Childhood/Paediatric/Infantile TGCTs -- 13.2.1.2 TGCTs of Adolescents and Young Adults -- 13.2.2 Sex Cord-Stromal Tumours -- 13.2.2.1 Leydig Cell Tumours -- 13.2.2.2 Sertoli Cell Tumours -- 13.2.2.3 Other Tumours -- 13.3 Clinical Management of Testicular Tumours -- 13.3.1 Diagnostic Procedures -- 13.3.1.1 Imaging -- 13.3.1.2 Tumour Markers in Blood -- 13.3.1.3 Hormone Profiles -- 13.3.1.4 Histopathological Assessment -- 13.3.2 Surgery, Staging, and Oncological Treatment -- 13.3.2.1 Childhood (Paediatric) Tumours -- 13.3.2.2 Testicular Germ Cell Tumours in Adolescents -- 13.3.2.3 Sex Cord-Stromal Tumours in Adolescents -- 13.3.2.4 Fertility Preservation in Children and Adolescents -- 13.4 Long-Term Consequences of Testicular Tumours in Childhood and Adolescence -- References -- 14: Gender Dysphoria: Management in the Transition age -- 14.1 Introduction -- 14.2 Puberty Suspension -- 14.2.1 Criticalities of GnRHa Treatment -- 14.3 Puberty Induction -- 14.3.1 Transgender Girls -- 14.3.2 Transgender Boys -- 14.4 Conclusions -- References -- 15: Preserving Fertility in Adolescents -- 15.1 Introduction -- 15.2 Spermatogenesis -- 15.3 Gonadotoxic Treatments: Mechanisms of Damage -- 15.4 Gonadotoxic Treatments: Clinical Effects -- 15.5 Cryopreservation -- 15.6 Prepuberty -- 15.7 Discussion -- 15.8 Conclusions -- References.
• Titolo autorizzato: Pediatric and Adolescent Andrology
• ISBN: 3-030-80015-6
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9910506379503321
• Lo trovi qui: Univ. Federico II
• Serie: Trends in andrology and sexual medicine.