{"text_format":"2","workbook":"xls","n_sheets":1,"sheets":["report2"],"not_rendered":{"charts":0,"images":0,"macros":0,"external_links":1,"defined_names":1,"comments":0,"pivot_tables":0},"unopened":[],"bounds":{"document_bytes":16777216,"sheet_cells":100000,"run_cost":"one","rows_first":2000,"rows_last":500,"rows_between":2000,"halvings":0,"cell_chars":16384,"cell_head_chars":4096},"cells_cut":0,"cells_raw":0,"read":"whole","date_system":"1900","formulas":"cached_only"}

{"sheet":"report2","index":0,"n_rows":24,"n_cols":5,"rows_kept":24,"cut":false,"hidden":false,"merged":[[0,2,0,3],[0,4,0,5],[1,2,1,3],[1,4,1,5],[2,2,2,3],[4,2,4,3],[5,2,5,3],[6,2,6,3],[7,2,7,3],[8,2,8,3],[13,2,13,3],[14,2,14,3],[16,2,16,3]],"flags":["formulas_cached_only"]}
[null,"1.","Record Nr.",null,"UNINA9910506379503321"]
[null,null,"Titolo",null,"Pediatric and adolescent andrology / / Carlo Foresta, Daniele Gianfrilli, editors"]
[null,null,"Pubbl/distr/stampa",null,"Cham, Switzerland : , : Springer, , [2021]"]
[{"$nulls":4},"©2021"]
[null,null,"ISBN",null,"3-030-80015-6"]
[null,null,"Descrizione fisica",null,"1 online resource (282 pages)"]
[null,null,"Collana",null,"Trends in Andrology and Sexual Medicine"]
[null,null,"Disciplina",null,"616.65"]
[null,null,"Soggetti",null,"Andrology"]
[{"$nulls":4},"Pediatric andrology"]
[{"$nulls":4},"Andrologia"]
[{"$nulls":4},"Urologia pediàtrica"]
[{"$nulls":4},"Llibres electrònics"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,"Nota di contenuto",null,"Intro -- Preface -- Contents -- 1: Genetics and Alterations in the Development of Male Reproductive System: Diagnosis and Clinical Management -- 1.1  Physiology of Male Sex Determination and Sexual Differentiation -- 1.2  Pathophysiology of Male Sex Determination and Sexual Differentiation -- 1.3  Clinical Manifestations of Mutations in Genes Involved in Sex Determination -- 1.3.1  46,XX Testicular/Ovo-Testicular DSD -- 1.3.2  46,XY Gonadal Dysgenesis/Ovo-Testicular DSD -- 1.4  Clinical Manifestations of Mutations in Genes Involved in Sexual Differentiation -- 1.4.1  Disorders of Androgen Biosynthesis: Reduced Androgen Levels -- 1.4.2  Disorders of Androgen Biosynthesis: Androgen Excess -- 1.4.3  Disorders of Testosterone Metabolism -- 1.4.4  Disorders of Androgen Action -- 1.4.5  Disruption of Leydig Cell Differentiation -- 1.4.6  Persistent Müllerian Duct Syndrome (PMDS) -- 1.5  Diagnosis and Clinical Management of DSD Patients -- 1.6  Conclusions -- References -- 2: Impact of Endocrine Disruptors on Male Sexual Development -- 2.1  Introduction -- 2.2  Bisphenol A -- 2.3  Phthalates -- 2.4  Perfluoroalkyl Compounds -- 2.5  Conclusions -- References -- 3: From Genetics to Epigenetics: New Insights into Male Reproduction -- 3.1  Introduction (Genetic Versus Epigenetic Cause of Male Infertility) -- 3.2  Molecular Basis of Epigenetics -- 3.3  "]
[{"$nulls":4},"Epigenetics and Human Spermatogenesis -- 3.4  Factors Affecting Epigenetic Modifications in Sperm -- 3.4.1  Lifestyle Factors (Diet, Exercise, Obesity, Smoke) -- 3.4.2  Environmental Factors (Endocrine Disruptors, Psychological Stress, Pollution, Heat, Toxins, Ionizing Radiation) -- 3.5  Transgenerational Inheritance -- 3.6  Assisted Reproductive Technique (ART) -- 3.7  Conclusions -- References -- 4: Medical and Surgical Treatment of Congenital Anomalies of Male Genital Tract -- 4.1  Introduction."]
[{"$nulls":4},"4.2  Disorders of Male Sexual Development (DSD) -- 4.2.1  DSD Due to Androgen Biosynthesis Problems or Actions -- 4.2.2  Diagnosis of DSD -- 4.2.3  Treatment -- 4.2.3.1  Medical Therapy -- Puberty Induction in Phenotypic Males with 46,XY Disorders of Sex Development -- Puberty Induction in Phenotypic Females with 46,XY Disorders of Sex Development -- 4.2.3.2  Surgical Therapy -- Phallic Reconstruction -- Feminizing Genitoplasty -- 4.3  Isolated Cryptorchidism -- 4.3.1  Pathophysiology -- 4.3.2  Surgical Treatment -- 4.3.3  Medical Treatment -- 4.4  Isolated Hypospadias -- 4.4.1  Treatment -- 4.5  Anorchia -- 4.6  Congenital Penile Curvature -- References -- 5: Disorders of Pubertal Development: From Hypogonadotropic Hypogonadism to Constitutional Delay of Puberty -- 5.1  Background -- 5.2  Normal Puberty -- 5.2.1  Physiology -- 5.2.2  External Pubertal Development -- 5.2.3  Onset of Puberty -- 5.3  Normal Variants of Puberty -- 5.3.1  Delayed Puberty -- 5.4  Disorders of Puberty -- 5.4.1  Incomplete/Absent Puberty -- 5.5  Functional Hypogonadotropic Hypogonadism -- 5.5.1  Nutritional Hypogonadotropic Hypogonadism -- 5.5.2  Psychosocial Factors -- 5.5.3  Clinical Impact of Functional Hypogonadotropic Hypogonadism -- 5.5.4  Assessment of Suspected Functional Hypogonadotropic Hypogonadism -- 5.5.5  Management of Functional Hypogonadotropic Hypogonadism -- 5.6  Congenital Hypogonadotropic Hypogonadism -- 5.7  Acquired Hypogonadotropic Hypogonadism -- 5.7.1  Pituitary Tumours -- 5.7.2  Pubertal Effects of Treatment for Childhood Malignancies -- 5.8  Management of Hypogonadotropic Hypogonadism -- 5.9  Pubertal Induction -- 5.9.1  Testosterone Esters -- 5.9.2  Other Options -- 5.9.3  Side Effects -- 5.10  Conclusion -- References -- 6: Disorders of Pubertal Development: Precocious Puberty -- 6.1  Introduction -- 6.2  Central Precocious Puberty."]
[{"$nulls":4},"6.2.1  Causes -- 6.2.2  Evaluation -- 6.2.3  Medical History and Physical Examination -- 6.2.4  Bone Age -- 6.2.5  Laboratory evaluation -- 6.2.6  Imaging -- 6.2.7  Treatment -- 6.3  Peripheral Precocious Puberty -- 6.3.1  Causes -- 6.4  Evaluation -- 6.4.1  Medical History and Physical Examination -- 6.4.2  Bone Age -- 6.4.3  Laboratory Evaluation -- 6.4.4  Imaging -- 6.4.4.1  Treatment -- 6.5  Benign or Nonprogressive Pubertal Variants -- References -- 7: Clinical Management and Treatment of Varicocele in the Adolescence -- 7.1  Introduction -- 7.2  Pathogenesis of Testicular Damage -- 7.3  Diagnostic Evaluation -- 7.4  Management -- 7.5  Treatment Options -- 7.6  Established Guidelines -- 7.7  Conclusions and Authors' Recommendations -- References -- 8: Congenital Causes of Hypergonadotropic Hypogonadism: Anorchia and Klinefelter Syndrome -- 8.1  Anorchia -- 8.1.1  Etiology and Diagnosis -- 8.1.2  Clinical and Biochemical Presentation -- 8.2  Klinefelter Syndrome -- 8.2.1  Etiology and Diagnosis -- 8.2.2  Genetics -- 8.2.3  Clinical and Biochemical Presentation -- 8.2.3.1  Infancy -- 8.2.3.2  Prepubertal Boys -- 8.2.3.3  Puberty -- 8.2.3.4  Adulthood -- 8.2.4  Testicular Histology -- 8.2.5  Fertility -- 8.2.6  Neurodevelopmental and Psychosocial Presentation -- 8.2.7  Gender Identity, Sexuality, and Sexual Function -- 8.2.8  Comorbidities -- 8.3  Testosterone "]
[{"$nulls":4},"Treatment -- 8.3.1  Anorchia -- 8.3.2  Klinefelter Syndrome -- References -- 9: Acquired Testicular Disorders -- 9.1  Testicular Trauma -- 9.1.1  Epidemiology -- 9.1.2  Etiology and Pathophysiology -- 9.1.3  Clinical Presentation -- 9.1.4  Diagnosis -- 9.1.5  Management and Treatment -- 9.2  Testicular Torsion -- 9.2.1  Epidemiology -- 9.2.2  Etiology and Pathophysiology -- 9.2.3  Clinical Presentation -- 9.2.4  Diagnosis -- 9.2.5  Complications -- 9.2.6  Management and Treatment."]
[{"$nulls":4},"9.3  Orchitis -- 9.3.1  Epidemiology and Classification -- 9.3.2  Etiology and Pathophysiology -- 9.3.2.1  Infectious Epididymo-Orchitis -- 9.3.2.2  Noninfectious Epididymo-Orchitis -- 9.3.3  Clinical Presentation -- 9.3.4  Diagnosis -- 9.3.4.1  History and Physical Examination -- 9.3.4.2  Diagnostic Testing -- 9.3.5  Complications -- 9.3.6  Management and Treatment -- 9.3.7  Follow-Up -- 9.4  Testicular Iatrogenic Damage -- 9.4.1  CT-Associated Testicular Damage -- 9.4.2  SCT-Related Testicular Damage -- 9.4.3  RT-Associated Testicular Damage -- 9.4.4  Endocrine Evaluation in Cancer Survivors -- 9.4.5  Other Causes of Iatrogenic Testicular Damage -- 9.5  Conclusions -- References -- 10: Risk Factors Affecting Puberty: Environment, Obesity, and Lifestyles -- 10.1  Introduction -- 10.2  Risk Factors Affecting Puberty: Environment, Obesity, and Lifestyles -- 10.3  Environment -- 10.4  Obesity -- 10.5  Lifestyles -- 10.6  Negative Energy Balance: Severe Malnutrition and Vigorous Physical Activity -- 10.7  Conclusions -- References -- 11: Sexually Transmitted Infections and Risk Behaviors in the Adolescence -- 11.1  Introduction -- 11.2  Epidemiology -- 11.3  Risk Factors for STIs in Adolescents -- 11.4  Screening for STIs in Adolescents -- 11.4.1  Investigation of Sexual History -- 11.4.2  Physical Examination -- 11.5  Prevention of HIV Risk: Preexposure Prophylaxis -- 11.6  Confidentiality in Adolescent Patient-Physician Relationship -- References -- 12: Sexual Disorders in Adolescents and Young Adults -- 12.1  Introduction -- 12.2  Sexual Dysfunctions in Adolescence -- 12.3  Sexual Dysfunctions in Young Adults -- 12.4  Internet-Related Sexual Disorders in Youths -- 12.5  Sex Education -- 12.6  Conclusions -- References -- 13: Diagnosis and Management of Testicular Tumours in Children and Adolescents -- 13.1  General Introduction."]
[{"$nulls":4},"13.2  Histopathology, Biological Features, and Diagnostic Markers -- 13.2.1  Testicular Germ Cell Tumours -- 13.2.1.1  Childhood/Paediatric/Infantile TGCTs -- 13.2.1.2  TGCTs of Adolescents and Young Adults -- 13.2.2  Sex Cord-Stromal Tumours -- 13.2.2.1  Leydig Cell Tumours -- 13.2.2.2  Sertoli Cell Tumours -- 13.2.2.3  Other Tumours -- 13.3  Clinical Management of Testicular Tumours -- 13.3.1  Diagnostic Procedures -- 13.3.1.1  Imaging -- 13.3.1.2  Tumour Markers in Blood -- 13.3.1.3  Hormone Profiles -- 13.3.1.4  Histopathological Assessment -- 13.3.2  Surgery, Staging, and Oncological Treatment -- 13.3.2.1  Childhood (Paediatric) Tumours -- 13.3.2.2  Testicular Germ Cell Tumours in Adolescents -- 13.3.2.3  Sex Cord-Stromal Tumours in Adolescents -- 13.3.2.4  Fertility Preservation in Children and Adolescents -- 13.4  Long-Term Consequences of Testicular Tumours in Childhood and Adolescence -- References -- 14: Gender Dysphoria: Management in the Transition age -- 14.1  Introduction -- 14.2  Puberty Suspension -- 14.2.1  Criticalities of GnRHa Treatment -- 14.3  Puberty Induction -- 14.3.1  Transgender Girls -- 14.3.2  Transgender Boys -- 14.4  Conclusions -- References -- 15: Preserving Fertility in Adolescents -- 15.1  Introduction -- 15.2  Spermatogenesis -- 15.3  Gonadotoxic Treatments: Mechanisms of Damage -- 15.4  Gonadotoxic Treatments: Clinical Effects -- 15.5  Cryopreservation -- 15.6  Prepuberty -- 15.7  "]
[{"$nulls":4},"Discussion -- 15.8  Conclusions -- References."]