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Novel Optical Endoscopes for Early Cancer Diagnosis and Therapy / / by Dale Jonathan Waterhouse



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Autore: Waterhouse Dale Jonathan Visualizza persona
Titolo: Novel Optical Endoscopes for Early Cancer Diagnosis and Therapy / / by Dale Jonathan Waterhouse Visualizza cluster
Pubblicazione: Cham : , : Springer International Publishing : , : Imprint : Springer, , 2019
Edizione: 1st ed. 2019.
Descrizione fisica: 1 online resource (161 pages)
Disciplina: 616.3307545
616.07545
Soggetto topico: Medical physics
Radiation
Lasers
Photonics
Radiology
Cancer research
Medical and Radiation Physics
Optics, Lasers, Photonics, Optical Devices
Diagnostic Radiology
Cancer Research
Note generali: "Doctoral thesis accepted by the University of Cambridge, Cambridge, UK"--Title page.
Nota di contenuto: Translation of Optical Imaging Techniques -- Flexible Endoscopy: Early Detection of Dysplasia in Barrett’s Oesophagus -- Flexible Endoscopy : Device Architecture -- Flexible Endoscopy: Optical Molecular Imaging -- Flexible Endoscopy: Multispectral Imaging -- Rigid Endoscopy for Intraoperative Imaging of Pituitary Adenoma -- Conclusions and Outlook -- Appendix.
Sommario/riassunto: This thesis describes the design, development, characterisation and clinical translation of three novel devices for optical endoscopic imaging. Over the past decade, rapid innovation in optics and photonics has led to the availability of low-cost and high-performance optical technologies that can be exploited for biomedical applications, but relatively few have been translated into clinic. The work presented outlines for the first time, a comprehensive analysis of the common barriers and unique challenges associated with the translation of optical imaging techniques. To assist developers streamline translation of optical imaging devices in future, a roadmap to clinical translation is outlined, and key translational characteristics are defined. Guided by these, subsequent development of endoscopic devices resulted in preparation and approval of endoscopes for first in human trials in the oesophagus, for early detection of cancer, and in the brain, for delineation of tumour during surgical resection. The thesis culminates in the presentation of results from the first in human use of a compact multispectral endoscope for imaging endogenous tissue contrast in the oesophagus. With continuation of the work as outlined at the end of this thesis, the novel techniques described have the potential to improve the standard of care in their respective indications.
Titolo autorizzato: Novel Optical Endoscopes for Early Cancer Diagnosis and Therapy  Visualizza cluster
ISBN: 3-030-21481-8
Formato: Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione: Inglese
Record Nr.: 9910337868803321
Lo trovi qui: Univ. Federico II
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Serie: Springer Theses, Recognizing Outstanding Ph.D. Research, . 2190-5053