04193nam 22006375 450 991033786880332120200703164742.03-030-21481-810.1007/978-3-030-21481-4(CKB)4100000008701219(MiAaPQ)EBC5813790(DE-He213)978-3-030-21481-4(PPN)238489744(EXLCZ)99410000000870121920190709d2019 u| 0engurcnu||||||||txtrdacontentcrdamediacrrdacarrierNovel Optical Endoscopes for Early Cancer Diagnosis and Therapy[electronic resource] /by Dale Jonathan Waterhouse1st ed. 2019.Cham :Springer International Publishing :Imprint: Springer,2019.1 online resource (161 pages)Springer Theses, Recognizing Outstanding Ph.D. Research,2190-5053"Doctoral thesis accepted by the University of Cambridge, Cambridge, UK"--Title page.3-030-21480-X Translation of Optical Imaging Techniques -- Flexible Endoscopy: Early Detection of Dysplasia in Barrett’s Oesophagus -- Flexible Endoscopy : Device Architecture -- Flexible Endoscopy: Optical Molecular Imaging -- Flexible Endoscopy: Multispectral Imaging -- Rigid Endoscopy for Intraoperative Imaging of Pituitary Adenoma -- Conclusions and Outlook -- Appendix.This thesis describes the design, development, characterisation and clinical translation of three novel devices for optical endoscopic imaging. Over the past decade, rapid innovation in optics and photonics has led to the availability of low-cost and high-performance optical technologies that can be exploited for biomedical applications, but relatively few have been translated into clinic. The work presented outlines for the first time, a comprehensive analysis of the common barriers and unique challenges associated with the translation of optical imaging techniques. To assist developers streamline translation of optical imaging devices in future, a roadmap to clinical translation is outlined, and key translational characteristics are defined. Guided by these, subsequent development of endoscopic devices resulted in preparation and approval of endoscopes for first in human trials in the oesophagus, for early detection of cancer, and in the brain, for delineation of tumour during surgical resection. The thesis culminates in the presentation of results from the first in human use of a compact multispectral endoscope for imaging endogenous tissue contrast in the oesophagus. With continuation of the work as outlined at the end of this thesis, the novel techniques described have the potential to improve the standard of care in their respective indications.Springer Theses, Recognizing Outstanding Ph.D. Research,2190-5053Medical physicsRadiationLasersPhotonicsRadiologyCancer researchMedical and Radiation Physicshttps://scigraph.springernature.com/ontologies/product-market-codes/P27060Optics, Lasers, Photonics, Optical Deviceshttps://scigraph.springernature.com/ontologies/product-market-codes/P31030Diagnostic Radiologyhttps://scigraph.springernature.com/ontologies/product-market-codes/H29013Cancer Researchhttps://scigraph.springernature.com/ontologies/product-market-codes/B11001Medical physics.Radiation.Lasers.Photonics.Radiology.Cancer research.Medical and Radiation Physics.Optics, Lasers, Photonics, Optical Devices.Diagnostic Radiology.Cancer Research.616.3307545Waterhouse Dale Jonathanauthttp://id.loc.gov/vocabulary/relators/aut1062097BOOK9910337868803321Novel Optical Endoscopes for Early Cancer Diagnosis and Therapy2522928UNINA