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Hepatobiliary transport in health and disease / / edited by Dieter Häussinger, Verena Keitel and Ralf Kubitz



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Autore: Häussinger D (Dieter), <1951-> Visualizza persona
Titolo: Hepatobiliary transport in health and disease / / edited by Dieter Häussinger, Verena Keitel and Ralf Kubitz Visualizza cluster
Pubblicazione: Berlin, : De Gruyter, c2012
Edizione: 1st ed.
Descrizione fisica: 1 online resource (312 p.)
Disciplina: 612.3/52
Soggetto topico: Liver - Metabolism - Disorders
Biliary tract - Metabolism - Disorders
Altri autori: HäussingerD <1951-> (Dieter)  
KeitelVerena  
KubitzRalf  
Note generali: Description based upon print version of record.
Nota di bibliografia: Includes bibliographical references and index.
Nota di contenuto: Sodium-dependent bile salt uptake -- Sodium-independent bile salt uptake into hepatocytes -- Bile salt export across the canalicular membrane -- Bile salt salvage systems.
Sommario/riassunto: One major function of the liver is the uptake of endo- and xenobiotics from the bloodstream and their excretion into bile. The transport systems involved in hepatobiliary transport have been recently cloned and characterized at the molecular level and it is becoming clear that mutations and polymorphisms of individual transporter molecules underlie a variety of liver diseases. Furthermore, new research has shown that bile acids, whose function in digestion is long known, also behave as signal molecules in a variety of organs, including the intestinal and biliary epithelia, sinusoidal endothelial and immune cells. This book provides indepth surveys on the structure and function of transport molecules involved in hepatobiliary transport, on the role of different bile acids receptors in various organs and their function in health and disease, the mechanisms of bile salt-induced apoptosis and hepatocyte protection, and the role of transporter mutations as causes and modifiers of liver diseases. The book will be of interest not only for biochemists, structural chemists and biologists, but also for clinicians.
Titolo autorizzato: Hepatobiliary transport in health and disease  Visualizza cluster
ISBN: 1-283-85800-2
3-11-027934-7
3-11-027935-5
Formato: Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione: Inglese
Record Nr.: 9910826571303321
Lo trovi qui: Univ. Federico II
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