LEADER 03328nam 2200661 a 450 001 9910826571303321 005 20240516150023.0 010 $a1-283-85800-2 010 $a3-11-027934-7 010 $a3-11-027935-5 024 7 $a10.1515/9783110279344 035 $a(CKB)2670000000211111 035 $a(EBL)893693 035 $a(OCoLC)796384275 035 $a(SSID)ssj0000677810 035 $a(PQKBManifestationID)12347292 035 $a(PQKBTitleCode)TC0000677810 035 $a(PQKBWorkID)10697557 035 $a(PQKB)11258604 035 $a(MiAaPQ)EBC893693 035 $a(DE-B1597)175368 035 $a(OCoLC)881293266 035 $a(DE-B1597)9783110279344 035 $a(Au-PeEL)EBL893693 035 $a(CaPaEBR)ebr10582267 035 $a(CaONFJC)MIL417050 035 $a(EXLCZ)992670000000211111 100 $a20120119d2012 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aHepatobiliary transport in health and disease$b[electronic resource] /$fedited by Dieter Ha?ussinger, Verena Keitel and Ralf Kubitz 205 $a1st ed. 210 $aBerlin $cDe Gruyter$dc2012 215 $a1 online resource (312 p.) 300 $aDescription based upon print version of record. 311 $a3-11-027899-5 320 $aIncludes bibliographical references and index. 327 $aSodium-dependent bile salt uptake -- Sodium-independent bile salt uptake into hepatocytes -- Bile salt export across the canalicular membrane -- Bile salt salvage systems. 330 $aOne major function of the liver is the uptake of endo- and xenobiotics from the bloodstream and their excretion into bile. The transport systems involved in hepatobiliary transport have been recently cloned and characterized at the molecular level and it is becoming clear that mutations and polymorphisms of individual transporter molecules underlie a variety of liver diseases. Furthermore, new research has shown that bile acids, whose function in digestion is long known, also behave as signal molecules in a variety of organs, including the intestinal and biliary epithelia, sinusoidal endothelial and immune cells. This book provides indepth surveys on the structure and function of transport molecules involved in hepatobiliary transport, on the role of different bile acids receptors in various organs and their function in health and disease, the mechanisms of bile salt-induced apoptosis and hepatocyte protection, and the role of transporter mutations as causes and modifiers of liver diseases. The book will be of interest not only for biochemists, structural chemists and biologists, but also for clinicians. 606 $aLiver$xMetabolism$xDisorders 606 $aBiliary tract$xMetabolism$xDisorders 615 0$aLiver$xMetabolism$xDisorders. 615 0$aBiliary tract$xMetabolism$xDisorders. 676 $a612.3/52 700 $aHa?ussinger$b D$g(Dieter),$f1951-$092464 701 $aHa?ussinger$b D$g(Dieter),$f1951-$092464 701 $aKeitel$b Verena$01639254 701 $aKubitz$b Ralf$01639255 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910826571303321 996 $aHepatobiliary transport in health and disease$93982115 997 $aUNINA