Environmental chemicals, enzyme function, and human disease

• Pubblicazione: Amsterdam ; ; New York : , : Excerpta Medica; New York : , : Elsevier/North-Holland, , 1980
• Edizione: 1st ed.
• Descrizione fisica: 1 online resource (392 pages)
• Disciplina: 615.9
• Soggetto topico: Toxicology; Drugs - Metabolism; Enzyme induction; Biotransformation (Metabolism)
• Note generali: "Symposium on Drug-Metabolizing Enzymes and Environmental Chemicals: Toxic Interactions, held at the Ciba Foundation, London, 23-25 October 1979"--Participants page.
• Nota di bibliografia: Includes bibliographical references and indexes.
• Nota di contenuto: Environmental Chemicals Enzyme Function and Human Disease; Contents; Chairman's introduction; The role of the drug-metabolizing enzymes; Discussion; The influence of inducers on drug-metabolizing enzyme activity and on formation of reactive drug metabolites in the liver; Discussion; Effects of inducers and inhibitors on drug-metabolizing enzymes and on drug toxicity in extrahepatic tissues; Discussion; Induction of enzymes involved in DNA repair and mutagenesis; Discussion ; Induction of drug-metabolizing enzymes by polycyclic aromatic hydrocarbons: mechanisms, and some implications in environmental health research; Discussion; Discussion; Induction of drug-metabolizing enzymes by phenobarbitone: structural and biochemical aspects; Substrate-dependent irreversible inactivation of cytochrome P-450: conversion of its haem moiety into modified porphyrins; Discussion; General Discussion I; Regulation of human drug metabolism by dietary factors; Discussion; Influence of foreign compounds on formation and disposition of reactive metabolites; Discussion ; Pharmacokinetic factors governing the steady-state concentrations of foreign chemicals and their metabolites; Discussion; Toxicological implications of polymorphic drug metabolism; Immunologically mediated toxicity; Discussion; Toxicological significance of liver hypertrophy produced by inducers of drug-metabolizing enzymes; Discussion; Discussion; Discussion; The influence of nutrition and inducers on mechanisms of toxicity in humans and animals; Influence of environmental chemicals on drug therapy in humans: studies with contraceptivesteroids; Discussion; General Discussion II ; Vitamin D metabolism in patients treated with phenytoin and phenobarbitone; Discussion; Chemical disease in humans: problems in comparative toxicology; Discussion; Implications for future studies in humans; Final General Discussion; Index of Contributors; Subject Index
• Sommario/riassunto: The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known as the Ciba Foundation, is well known to scientists and clinicians around the world.
• Titolo autorizzato: Environmental chemicals, enzyme function, and human disease
• ISBN: 9786613694317; 9781280783920; 1280783923; 9780470720592; 047072059X; 9780470718278; 0470718277
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9910806163003321
• Lo trovi qui: Univ. Federico II
• Serie: Ciba Foundation symposium ; ; new ser. 76.