LEADER 04175nam 2200685 a 450 001 9910806163003321 005 20230822182906.0 010 $a1-280-78392-3 010 $a9786613694317 010 $a0-470-72059-X 010 $a0-470-71827-7 035 $a(CKB)1000000000688128 035 $a(EBL)703898 035 $a(OCoLC)797918460 035 $a(SSID)ssj0000715468 035 $a(PQKBManifestationID)11410208 035 $a(PQKBTitleCode)TC0000715468 035 $a(PQKBWorkID)10704123 035 $a(PQKB)11698487 035 $a(MiAaPQ)EBC703898 035 $a(Au-PeEL)EBL703898 035 $a(CaPaEBR)ebr10575492 035 $a(CaONFJC)MIL369431 035 $a(EXLCZ)991000000000688128 100 $a19800605d1980 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aEnvironmental chemicals, enzyme function, and human disease 210 1$aAmsterdam ;$aNew York :$cExcerpta Medica ;$aNew York :$cElsevier/North-Holland,$d1980. 215 $a1 online resource (392 pages) 225 1 $aCiba Foundation symposium (new series) ;$v76. 300 $a"Symposium on Drug-Metabolizing Enzymes and Environmental Chemicals: Toxic Interactions, held at the Ciba Foundation, London, 23-25 October 1979"--Participants page. 311 0 $a0-470-66387-1 311 0 $a0-444-90157-4 320 $aIncludes bibliographical references and indexes. 327 $aEnvironmental Chemicals Enzyme Function and Human Disease; Contents; Chairman's introduction; The role of the drug-metabolizing enzymes; Discussion; The influence of inducers on drug-metabolizing enzyme activity and on formation of reactive drug metabolites in the liver; Discussion; Effects of inducers and inhibitors on drug-metabolizing enzymes and on drug toxicity in extrahepatic tissues; Discussion; Induction of enzymes involved in DNA repair and mutagenesis; Discussion 327 $aInduction of drug-metabolizing enzymes by polycyclic aromatic hydrocarbons: mechanisms, and some implications in environmental health research; Discussion; Discussion; Induction of drug-metabolizing enzymes by phenobarbitone: structural and biochemical aspects; Substrate-dependent irreversible inactivation of cytochrome P-450: conversion of its haem moiety into modified porphyrins; Discussion; General Discussion I; Regulation of human drug metabolism by dietary factors; Discussion; Influence of foreign compounds on formation and disposition of reactive metabolites; Discussion 327 $aPharmacokinetic factors governing the steady-state concentrations of foreign chemicals and their metabolites; Discussion; Toxicological implications of polymorphic drug metabolism; Immunologically mediated toxicity; Discussion; Toxicological significance of liver hypertrophy produced by inducers of drug-metabolizing enzymes; Discussion; Discussion; Discussion; The influence of nutrition and inducers on mechanisms of toxicity in humans and animals; Influence of environmental chemicals on drug therapy in humans: studies with contraceptivesteroids; Discussion; General Discussion II 327 $aVitamin D metabolism in patients treated with phenytoin and phenobarbitone; Discussion; Chemical disease in humans: problems in comparative toxicology; Discussion; Implications for future studies in humans; Final General Discussion; Index of Contributors; Subject Index 410 0$aCiba Foundation symposium ;$vnew ser. 76. 606 $aToxicology$vCongresses 606 $aDrugs$xMetabolism$vCongresses 606 $aEnzyme induction$vCongresses 606 $aBiotransformation (Metabolism)$vCongresses 615 0$aToxicology 615 0$aDrugs$xMetabolism 615 0$aEnzyme induction 615 0$aBiotransformation (Metabolism) 676 $a615.9 712 12$aSymposium on Environmental Chemicals, Enzyme Function, and Human Disease 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910806163003321 996 $aEnvironmental chemicals, enzyme function, and human disease$91963083 997 $aUNINA