LEADER 04771nam 2200781 a 450 001 9910806163003321 005 20240516065011.0 010 $a9786613694317 010 $a9781280783920 010 $a1280783923 010 $a9780470720592 010 $a047072059X 010 $a9780470718278 010 $a0470718277 035 $a(CKB)1000000000688128 035 $a(EBL)703898 035 $a(OCoLC)797918460 035 $a(SSID)ssj0000715468 035 $a(PQKBManifestationID)11410208 035 $a(PQKBTitleCode)TC0000715468 035 $a(PQKBWorkID)10704123 035 $a(PQKB)11698487 035 $a(MiAaPQ)EBC703898 035 $a(Au-PeEL)EBL703898 035 $a(CaPaEBR)ebr10575492 035 $a(CaONFJC)MIL369431 035 $a(Perlego)2759166 035 $a(EXLCZ)991000000000688128 100 $a19800605d1980 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aEnvironmental chemicals, enzyme function, and human disease 205 $a1st ed. 210 1$aAmsterdam ;$aNew York :$cExcerpta Medica ;$aNew York :$cElsevier/North-Holland,$d1980. 215 $a1 online resource (392 pages) 225 1 $aCiba Foundation symposium (new series) ;$v76. 300 $a"Symposium on Drug-Metabolizing Enzymes and Environmental Chemicals: Toxic Interactions, held at the Ciba Foundation, London, 23-25 October 1979"--Participants page. 311 0 $a9780470663875 311 0 $a0470663871 311 0 $a9780444901576 311 0 $a0444901574 320 $aIncludes bibliographical references and indexes. 327 $aEnvironmental Chemicals Enzyme Function and Human Disease; Contents; Chairman's introduction; The role of the drug-metabolizing enzymes; Discussion; The influence of inducers on drug-metabolizing enzyme activity and on formation of reactive drug metabolites in the liver; Discussion; Effects of inducers and inhibitors on drug-metabolizing enzymes and on drug toxicity in extrahepatic tissues; Discussion; Induction of enzymes involved in DNA repair and mutagenesis; Discussion 327 $aInduction of drug-metabolizing enzymes by polycyclic aromatic hydrocarbons: mechanisms, and some implications in environmental health research; Discussion; Discussion; Induction of drug-metabolizing enzymes by phenobarbitone: structural and biochemical aspects; Substrate-dependent irreversible inactivation of cytochrome P-450: conversion of its haem moiety into modified porphyrins; Discussion; General Discussion I; Regulation of human drug metabolism by dietary factors; Discussion; Influence of foreign compounds on formation and disposition of reactive metabolites; Discussion 327 $aPharmacokinetic factors governing the steady-state concentrations of foreign chemicals and their metabolites; Discussion; Toxicological implications of polymorphic drug metabolism; Immunologically mediated toxicity; Discussion; Toxicological significance of liver hypertrophy produced by inducers of drug-metabolizing enzymes; Discussion; Discussion; Discussion; The influence of nutrition and inducers on mechanisms of toxicity in humans and animals; Influence of environmental chemicals on drug therapy in humans: studies with contraceptivesteroids; Discussion; General Discussion II 327 $aVitamin D metabolism in patients treated with phenytoin and phenobarbitone; Discussion; Chemical disease in humans: problems in comparative toxicology; Discussion; Implications for future studies in humans; Final General Discussion; Index of Contributors; Subject Index 330 8 $aThe Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known as the Ciba Foundation, is well known to scientists and clinicians around the world. 410 0$aCiba Foundation symposium ;$vnew ser. 76. 606 $aToxicology$vCongresses 606 $aDrugs$xMetabolism$vCongresses 606 $aEnzyme induction$vCongresses 606 $aBiotransformation (Metabolism)$vCongresses 615 0$aToxicology 615 0$aDrugs$xMetabolism 615 0$aEnzyme induction 615 0$aBiotransformation (Metabolism) 676 $a615.9 712 12$aSymposium on Environmental Chemicals, Enzyme Function, and Human Disease 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910806163003321 996 $aEnvironmental chemicals, enzyme function, and human disease$91963083 997 $aUNINA