Peptide and protein desiegn for biopharmaceutical applications / / editor, Knud J. Jensen

• Pubblicazione: West Sussex, UK ; ; Hoboken, NJ, : Wiley, 2009
• Descrizione fisica: 1 online resource (314 p.)
• Disciplina: 615/.19
• Soggetto topico: Peptide drugs - Design; Protein drugs - Design; Peptides - Design; Protein engineering
• Altri autori: JensenKnud J
• Note generali: Description based upon print version of record.
• Nota di bibliografia: Includes bibliographical references and index.
• Nota di contenuto: Peptide and Protein Design for Biopharmaceutical Applications; Contents; List of Contributors; Preface; 1 Introduction; 2 Computational Approaches in Peptide and Protein Design: An Overview; 2.1 Introduction; 2.2 Basics and Tools; 2.2.1 The Importance of Computational Approaches; 2.2.2 Tools and Procedures: Force Fields and Sampling; 2.3 Computational Study of Cyclopentapeptide Inhibitors of CXCR4; 2.3.1 The 3D Pharmacophore Model for FC131; 2.3.2 A 3D Model of the TM Region of CXCR4; 2.3.3 Docking of FC131 to CXCR4; Acknowledgements; References; 3 Aspects of Peptidomimetics; 3.1 Introduction ; 3.2 Modified Peptides3.3 Pseudopeptides; 3.4 Secondary Structure Mimics (Excluding Turn Mimics); 3.4.1 -strand Mimetics; 3.4.2 Helix Mimetics; 3.5 Examples of Peptidomimetics; 3.6 Conclusion; References; 4 Design of Cyclic Peptides; 4.1 Introduction; 4.1.1 Pharmaceutical Research Today; 4.1.2 General Advantages of Cyclic Peptide Structures; 4.1.3 Examples of Cyclic Peptides of Medicinal Interest; 4.1.4 General Considerations; 4.2 Peptide Cyclization; 4.2.1 Possibilities of Peptide Cyclization; 4.2.2 Synthesis of Cyclic Peptides; 4.2.3 Chemical Modifications of Cyclic Peptides ; 4.2.4 Concluding Remarks4.3 Conformation and Dynamics of Cyclic Peptides; 4.3.1 Reductions in Conformational Space; 4.3.2 Conformational Arrangements in Cyclic Structures; 4.3.3 Flexibility of Cyclized Scaffolds; 4.3.4 Experimental Structure Characterization; 4.4 Concepts in the Rational Design of Cyclic Peptides; 4.4.1 The Influence of Amino Acid Composition; 4.4.2 The Dunitz-Waser Concept; 4.4.3 The Spatial Screening Technique; 4.4.4 General Strategy for Finding Active Hits; 4.5 Examples of Cyclic Peptides as Drug Candidates; 4.5.1 Cilengitide as Integrin Inhibitor; 4.5.2 CXCR4 Antagonists ; 4.5.3 Sandostatin and the Veber-Hirschmann Peptide as Examples of Rational Design4.6 Conclusion; References; 5 Carbohydrates in Peptide and Protein Design; 5.1 Introduction; 5.2 Configurational and Conformational Properties of Carbohydrates; 5.3 Carbohydrates in Peptidomimetics; 5.4 Glycopeptides; 5.5 Carbohydrates as Scaffolds in the Design of Nonpeptide Peptidomimetics; 5.6 Sugar Amino Acids; 5.7 Cyclodextrin-Peptide Conjugates; 5.8 Carboproteins: Protein Models on Carbohydrate Templates; 5.9 Conclusion; References; 6 De Novo Design of Proteins; 6.1 Introduction ; 6.2 Secondary Structure Elements6.2.1 The -helix; 6.2.2 The -sheet; 6.2.3 Loops, Turns and Templates; 6.3 Assembling a Specified Tertiary Structure from Secondary Structural Elements; 6.3.1 Computational Methods; 6.3.2 Coiled Coils; 6.3.3 -helical Bundles; 6.3.4 Fluorous Interactions; 6.3.5 Additional Topics; 6.4 Proteins on Templates; 6.5 Foldamers; 6.6 Biopharmaceutical Applications of De Novo Design; 6.6.1 -helical Structures in Biopharmaceutical Applications; 6.6.2 Foldamers in Biopharmaceutical Applications; References ; 7 Design of Insulin Variants for Improved Treatment of Diabetes
• Sommario/riassunto: Peptides serve as effective drugs in the clinic today. However the inherent drawbacks of peptide structures can limit their efficacy as drugs. To overcome this researchers are developing new methods to create 'tailor-made' peptides and proteins with improved pharmacological properties. Design of Peptides and Proteins provides an overview of the experimental and computational methods for peptide and protein design, with an emphasis on specific applications for therapeutics and biomedical research. Topics covered include: Computer modeling of peptides and prot
• Titolo autorizzato: Peptide and protein desiegn for biopharmaceutical applications
• ISBN: 1-282-29176-9; 9786612291760; 0-470-74971-7; 0-470-74970-9
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9910139761503321
• Lo trovi qui: Univ. Federico II