LEADER 05454nam 2200709Ia 450 001 9910139761503321 005 20200520144314.0 010 $a9786612291760 010 $a9781282291768 010 $a1282291769 010 $a9780470749715 010 $a0470749717 010 $a9780470749708 010 $a0470749709 035 $a(CKB)1000000000793110 035 $a(EBL)470587 035 $a(OCoLC)463438687 035 $a(SSID)ssj0000305734 035 $a(PQKBManifestationID)11228719 035 $a(PQKBTitleCode)TC0000305734 035 $a(PQKBWorkID)10305667 035 $a(PQKB)10212226 035 $a(MiAaPQ)EBC470587 035 $a(Perlego)2772853 035 $a(EXLCZ)991000000000793110 100 $a20090508d2009 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aPeptide and protein desiegn for biopharmaceutical applications /$feditor, Knud J. Jensen 210 $aWest Sussex, UK ;$aHoboken, NJ $cWiley$d2009 215 $a1 online resource (314 p.) 300 $aDescription based upon print version of record. 311 08$a9780470319611 311 08$a0470319615 320 $aIncludes bibliographical references and index. 327 $aPeptide and Protein Design for Biopharmaceutical Applications; Contents; List of Contributors; Preface; 1 Introduction; 2 Computational Approaches in Peptide and Protein Design: An Overview; 2.1 Introduction; 2.2 Basics and Tools; 2.2.1 The Importance of Computational Approaches; 2.2.2 Tools and Procedures: Force Fields and Sampling; 2.3 Computational Study of Cyclopentapeptide Inhibitors of CXCR4; 2.3.1 The 3D Pharmacophore Model for FC131; 2.3.2 A 3D Model of the TM Region of CXCR4; 2.3.3 Docking of FC131 to CXCR4; Acknowledgements; References; 3 Aspects of Peptidomimetics; 3.1 Introduction 327 $a3.2 Modified Peptides3.3 Pseudopeptides; 3.4 Secondary Structure Mimics (Excluding Turn Mimics); 3.4.1 -strand Mimetics; 3.4.2 Helix Mimetics; 3.5 Examples of Peptidomimetics; 3.6 Conclusion; References; 4 Design of Cyclic Peptides; 4.1 Introduction; 4.1.1 Pharmaceutical Research Today; 4.1.2 General Advantages of Cyclic Peptide Structures; 4.1.3 Examples of Cyclic Peptides of Medicinal Interest; 4.1.4 General Considerations; 4.2 Peptide Cyclization; 4.2.1 Possibilities of Peptide Cyclization; 4.2.2 Synthesis of Cyclic Peptides; 4.2.3 Chemical Modifications of Cyclic Peptides 327 $a4.2.4 Concluding Remarks4.3 Conformation and Dynamics of Cyclic Peptides; 4.3.1 Reductions in Conformational Space; 4.3.2 Conformational Arrangements in Cyclic Structures; 4.3.3 Flexibility of Cyclized Scaffolds; 4.3.4 Experimental Structure Characterization; 4.4 Concepts in the Rational Design of Cyclic Peptides; 4.4.1 The Influence of Amino Acid Composition; 4.4.2 The Dunitz-Waser Concept; 4.4.3 The Spatial Screening Technique; 4.4.4 General Strategy for Finding Active Hits; 4.5 Examples of Cyclic Peptides as Drug Candidates; 4.5.1 Cilengitide as Integrin Inhibitor; 4.5.2 CXCR4 Antagonists 327 $a4.5.3 Sandostatin and the Veber-Hirschmann Peptide as Examples of Rational Design4.6 Conclusion; References; 5 Carbohydrates in Peptide and Protein Design; 5.1 Introduction; 5.2 Configurational and Conformational Properties of Carbohydrates; 5.3 Carbohydrates in Peptidomimetics; 5.4 Glycopeptides; 5.5 Carbohydrates as Scaffolds in the Design of Nonpeptide Peptidomimetics; 5.6 Sugar Amino Acids; 5.7 Cyclodextrin-Peptide Conjugates; 5.8 Carboproteins: Protein Models on Carbohydrate Templates; 5.9 Conclusion; References; 6 De Novo Design of Proteins; 6.1 Introduction 327 $a6.2 Secondary Structure Elements6.2.1 The -helix; 6.2.2 The -sheet; 6.2.3 Loops, Turns and Templates; 6.3 Assembling a Specified Tertiary Structure from Secondary Structural Elements; 6.3.1 Computational Methods; 6.3.2 Coiled Coils; 6.3.3 -helical Bundles; 6.3.4 Fluorous Interactions; 6.3.5 Additional Topics; 6.4 Proteins on Templates; 6.5 Foldamers; 6.6 Biopharmaceutical Applications of De Novo Design; 6.6.1 -helical Structures in Biopharmaceutical Applications; 6.6.2 Foldamers in Biopharmaceutical Applications; References 327 $a7 Design of Insulin Variants for Improved Treatment of Diabetes 330 $aPeptides serve as effective drugs in the clinic today. However the inherent drawbacks of peptide structures can limit their efficacy as drugs. To overcome this researchers are developing new methods to create 'tailor-made' peptides and proteins with improved pharmacological properties. Design of Peptides and Proteins provides an overview of the experimental and computational methods for peptide and protein design, with an emphasis on specific applications for therapeutics and biomedical research. Topics covered include: Computer modeling of peptides and prot 606 $aPeptide drugs$xDesign 606 $aProtein drugs$xDesign 606 $aPeptides$xDesign 606 $aProtein engineering 615 0$aPeptide drugs$xDesign. 615 0$aProtein drugs$xDesign. 615 0$aPeptides$xDesign. 615 0$aProtein engineering. 676 $a615/.19 701 $aJensen$b Knud J$0209641 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910139761503321 996 $aPeptide and protein desiegn for biopharmaceutical applications$94197606 997 $aUNINA