Development of vaccines : from discovery to clinical testing / / edited by Manmohan Singh, Indresh K. Srivastava

• Pubblicazione: Hoboken, N.J., : John Wiley & Sons, c2011
• Edizione: 1st ed.
• Descrizione fisica: 1 online resource (478 p.)
• Disciplina: 615/.372
• Soggetto topico: Vaccines; Drug development; Drug stability
• Altri autori: Manmohan Singh <1964 November 8-> SrivastaIndresh K
• Note generali: Description based upon print version of record.
• Nota di bibliografia: Includes bibliographical references and index.
• Nota di contenuto: Microbial vaccines design : the reverse vaccinology approach / Roberto Rosini, Michele A. Barocchi, Rino Rappuoli -- Design and development of recombinant vaccines with viral properties / Gerd Lipowsky, Martin F. Bachmann -- Tools for vaccine design : prediction and validation of highly immunogenic and conserved class II epitopes, and development of epitope-driven vaccines / Anne S. De Groot ... [et al.] -- Virus like-particle vaccines advantages and challenges / Ted M. Ross ... [et al.] -- Design platforms of nanocapsules for human therapeutics or vaccines / Masaaki Kawano ... [et al.] -- Designing immunogens for vaccine development in reference to HIV / Aemro Kassa ... [et al.] -- ; Expression and purification of recombinant proteins for vaccine applications / Carlo Zambonelli, Deeann Martinez-Guzmann, and Indresh K. Srivastava -- DNA vaccines for infectious diesase / Samuel Stepenson, Manmohan Singh, Indresh K. Srivastava -- Developing stable cell lines for the production of vaccine antigens / Xiaotian Zhong ... [et al.] -- Spectroscopy of vaccines / C. Russell Middaugh, Sangeeta B. Joshi -- Biophysical characterization of protein antigens within vaccine formulations / Padima Malyala, Derek O'Hagan, Manmohan Singh -- Structural characteristics predict the stability of HIV / Zohar Biron ... [et al.] -- Selection of optimal adjuvants and product factors that affect vaccine immunogenicity / Wei Wang, Manmohan Singh -- Lyophilization and stabilization of vaccines / James Chesko ... [et al.] -- Effect of buffers and stabilizers on vaccine stability and efficacy / Shireesh P. Apte, Sydney Ugwu -- Selection of final product containers / Luis Baez, Adrian Distler -- From the lab to the clinic : filing a phase I IND for an investigational vaccine / Kenneth G. Surowitz.
• Sommario/riassunto: Development of Vaccines: From Discovery to Clinical Testing outlines the critical steps, and analytical tools and techniques, needed to take a vaccine from discovery through a successful clinical trial. Contributions from leading experts in the critical areas of vaccine expression, purification, formulation, pre-clinical testing and regulatory submissions make this book an authoritative collection of issues, challenges and solutions for progressing a biologic drug formulation from its early stage of discovery into its final clinical testing. A section with details and real-life experien
• Titolo autorizzato: Development of vaccines
• ISBN: 1-283-17565-7; 9786613175656; 1-118-02363-3; 1-118-02364-1; 1-118-02362-5
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9910813272203321
• Lo trovi qui: Univ. Federico II