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010   $a9786613175656
010   $a9781283175654
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035   $a(EBL)697480
035   $a(OCoLC)739118473
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035   $a(PQKBTitleCode)TC0000521990
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035   $a(PQKB)11628809
035   $a(MiAaPQ)EBC697480
035   $a(Au-PeEL)EBL697480
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100   $a20101116d2011      uy         0
101 0 $aeng
135   $aur|n|---|||||
181   $ctxt
182   $cc
183   $acr
200 00$aDevelopment of vaccines $efrom discovery to clinical testing /$fedited by Manmohan Singh, Indresh K. Srivastava
205   $a1st ed.
210   $aHoboken, N.J. $cJohn Wiley & Sons$dc2011
215   $a1 online resource (478 p.)
300   $aDescription based upon print version of record.
311 08$a9780470256374 
311 08$a0470256370 
320   $aIncludes bibliographical references and index.
327   $aMicrobial vaccines design : the reverse vaccinology approach / Roberto Rosini, Michele A. Barocchi, Rino Rappuoli -- Design and development of recombinant vaccines with viral properties / Gerd Lipowsky, Martin F. Bachmann -- Tools for vaccine design : prediction and validation of highly immunogenic and conserved class II epitopes, and development of epitope-driven vaccines / Anne S. De Groot ... [et al.] -- Virus like-particle vaccines advantages and challenges / Ted M. Ross ... [et al.] -- Design platforms of nanocapsules for human therapeutics or vaccines / Masaaki Kawano ... [et al.] -- Designing immunogens for vaccine development in reference to HIV / Aemro Kassa ... [et al.] --
327   $aExpression and purification of recombinant proteins for vaccine applications / Carlo Zambonelli, Deeann Martinez-Guzmann, and Indresh K. Srivastava -- DNA vaccines for infectious diesase / Samuel Stepenson, Manmohan Singh, Indresh K. Srivastava -- Developing stable cell lines for the production of vaccine antigens / Xiaotian Zhong ... [et al.] -- Spectroscopy of vaccines / C. Russell Middaugh, Sangeeta B. Joshi -- Biophysical characterization of protein antigens within vaccine formulations / Padima Malyala, Derek O'Hagan, Manmohan Singh -- Structural characteristics predict the stability of HIV / Zohar Biron ... [et al.] -- Selection of optimal adjuvants and product factors that affect vaccine immunogenicity / Wei Wang, Manmohan Singh -- Lyophilization and stabilization of vaccines / James Chesko ... [et al.] -- Effect of buffers and stabilizers on vaccine stability and efficacy / Shireesh P. Apte, Sydney Ugwu -- Selection of final product containers / Luis Baez, Adrian Distler -- From the lab to the clinic : filing a phase I IND for an investigational vaccine / Kenneth G. Surowitz.
330   $aDevelopment of Vaccines: From Discovery to Clinical Testing outlines the critical steps, and analytical tools and techniques, needed to take a vaccine from discovery through a successful clinical trial. Contributions from leading experts in the critical areas of vaccine expression, purification, formulation, pre-clinical testing and regulatory submissions make this book an authoritative collection of issues, challenges and solutions for progressing a biologic drug formulation from its early stage of discovery into its final clinical testing. A section with details and real-life experien
606   $aVaccines
606   $aDrug development
606   $aDrug stability
615  0$aVaccines.
615  0$aDrug development.
615  0$aDrug stability.
676   $a615/.372
701   $aManmohan Singh$f1964 November 8-$01646559
701   $aSrivasta$b Indresh K$01646560
801  0$bMiAaPQ
801  1$bMiAaPQ
801  2$bMiAaPQ
906   $aBOOK
912   $a9910813272203321
996   $aDevelopment of vaccines$93993625
997   $aUNINA