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Titolo: |
A handbook for DNA-encoded chemistry : theory and applications for exploring chemical space and drug discovery / / edited by Robert A. Goodnow, Jr. ; contributors Raksha A. Acharya [and twenty five others]
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Pubblicazione: | Hoboken, New Jersey : , : Wiley, , 2014 |
©2014 | |
Descrizione fisica: | 1 online resource (497 p.) |
Disciplina: | 615.1/9 |
Soggetto topico: | Combinatorial Chemistry Techniques |
DNA - chemical synthesis | |
Drug Discovery | |
Gene Library - Small Molecule Libraries | |
Small Molecule Libraries - chemical synthesis | |
Persona (resp. second.): | GoodnowRobert A. |
AcharyaRaksha A. | |
Note generali: | Description based upon print version of record. |
Nota di bibliografia: | Includes bibliographical references at the end of each chapters and index. |
Nota di contenuto: | Just enough knowledge? -- A brief history of the development of combinatorial chemistry and the emerging need for DNA-encoded chemistry -- A history of DNA-encoding -- DNA-compatible chemistry -- Foundations of a DNA-encoded library (DEL) -- Practices for synthesizing DNA-encoded libraries -- Chemical gene design for DNA-encoded libraries -- Analytical challenges for DNA-encoded library systems -- Information technology: functionality and architectures for DNA-encoding -- Theoretical considerations of the application of DNA-encoded libraries to drug discovery -- Begin with the end in mind : the hit-to-lead process -- Enumeration and visualization of large combinatorial chemical libraries -- Screening large compound collections -- Reported applications of DNA-encoded library chemistry -- Dual-pharmacophore DNA-encoded chemical libraries -- Hit identification and hit follow-up -- Using DNA to program chemical synthesis, discover new reactions, and detect ligand binding -- An outlook and the changing feasibility and economics of chemical diversity exploration with DNA-encoded combinatorial approaches -- Keeping the promise? an outlook on dna chemical library technology. |
Sommario/riassunto: | This book comprehensively describes the development and practice of DNA-encoded library synthesis technology. Together, the chapters detail an approach to drug discovery that offers an attractive addition to the portfolio of existing hit generation technologies such as high-throughput screening, structure-based drug discovery and fragment-based screening. The book: Provides a valuable |
Titolo autorizzato: | A handbook for DNA-encoded chemistry ![]() |
ISBN: | 1-118-83267-1 |
1-118-83273-6 | |
1-118-83269-8 | |
Formato: | Materiale a stampa ![]() |
Livello bibliografico | Monografia |
Lingua di pubblicazione: | Inglese |
Record Nr.: | 9910806871903321 |
Lo trovi qui: | Univ. Federico II |
Opac: | Controlla la disponibilità qui |