03840nam 2200697 450 991080687190332120200520144314.01-118-83267-11-118-83273-61-118-83269-8(CKB)2550000001273475(EBL)1662195(SSID)ssj0001180028(PQKBManifestationID)11798008(PQKBTitleCode)TC0001180028(PQKBWorkID)11185370(PQKB)11618195(OCoLC)863127741(MiAaPQ)EBC1662195(DLC) 2013046115(Au-PeEL)EBL1662195(CaPaEBR)ebr10856833(CaONFJC)MIL595502(PPN)224810324(EXLCZ)99255000000127347520140416h20142014 uy 0engurcnu||||||||txtccrA handbook for DNA-encoded chemistry theory and applications for exploring chemical space and drug discovery /edited by Robert A. Goodnow, Jr. ; contributors Raksha A. Acharya [and twenty five others]Hoboken, New Jersey :Wiley,2014.©20141 online resource (497 p.)Description based upon print version of record.1-118-48768-0 1-306-64251-5 Includes bibliographical references at the end of each chapters and index.Just enough knowledge? -- A brief history of the development of combinatorial chemistry and the emerging need for DNA-encoded chemistry -- A history of DNA-encoding -- DNA-compatible chemistry -- Foundations of a DNA-encoded library (DEL) -- Practices for synthesizing DNA-encoded libraries -- Chemical gene design for DNA-encoded libraries -- Analytical challenges for DNA-encoded library systems -- Information technology: functionality and architectures for DNA-encoding -- Theoretical considerations of the application of DNA-encoded libraries to drug discovery -- Begin with the end in mind : the hit-to-lead process -- Enumeration and visualization of large combinatorial chemical libraries -- Screening large compound collections -- Reported applications of DNA-encoded library chemistry -- Dual-pharmacophore DNA-encoded chemical libraries -- Hit identification and hit follow-up -- Using DNA to program chemical synthesis, discover new reactions, and detect ligand binding -- An outlook and the changing feasibility and economics of chemical diversity exploration with DNA-encoded combinatorial approaches -- Keeping the promise? an outlook on dna chemical library technology.This book comprehensively describes the development and practice of DNA-encoded library synthesis technology. Together, the chapters detail an approach to drug discovery that offers an attractive addition to the portfolio of existing hit generation technologies such as high-throughput screening, structure-based drug discovery and fragment-based screening. The book: Provides a valuableCombinatorial Chemistry TechniquesMethodsDNAchemical synthesisDrug DiscoveryMethodsGene LibrarySmall Molecule LibrariesSmall Molecule Librarieschemical synthesisCombinatorial Chemistry TechniquesDNAchemical synthesis.Drug DiscoveryGene LibrarySmall Molecule Libraries.Small Molecule Librarieschemical synthesis.615.1/9Goodnow Robert A.Acharya Raksha A.MiAaPQMiAaPQMiAaPQBOOK9910806871903321A handbook for DNA-encoded chemistry4023398UNINA