Autophagy in stem cell maintenance and differentiation / / edited by Bhupendra V. Shravage, Kursad Turksen

• Pubblicazione: Cham, Switzerland : , : Springer, , [2023]; ©2023
• Descrizione fisica: 1 online resource (290 pages)
• Disciplina: 050
• Soggetto topico: Autophagic vacuoles
• Persona (resp. second.): ShravageBhupendra V.; TurksenKursad
• Nota di bibliografia: Includes bibliographical references and index.
• Nota di contenuto: Intro -- Preface -- Contents -- 1 Assays for Monitoring Autophagy in Stem Cells -- Introduction -- Autophagy Process and Mechanism -- Techniques for Assessing Autophagy Orchestration -- Electron Microscopy Imaging -- Fluorescence Microscopy -- LC3 Antibody Tagging -- Fluorescent Protein Tagging of LC3 -- mRFP/mCherry-GFP-LC3 Tandem Reporter Constructs and Their Advancements -- GFP-LC3-RFP-LC3∆G -- SQSTM/p62/Ref(2)P Tagging -- Evaluation of Specific Steps During Autophagy -- Autophagy Visualization Dyes -- Tracking Mitophagy in Stem Cells -- Atg8s/LC3 and p62 Protein Expression in Stem Cells -- LC3 Turnover Assays -- Flow Cytometry and Fluorescence-Associated Cell Sorting (FACS) -- Potential Probes for Monitoring Autophagy -- Gene Expression Assays -- Protein Interaction Databases -- Conclusion -- References -- 2 Autophagy in Stem Cell Maintenance and Differentiation -- Introduction -- Autophagy Compared to Necrosis and Apoptosis -- The Autophagic Cascade -- Types of Autophagy -- Role of Autophagy in Stem Cell Maintenance -- Role of Autophagy in Maintenance of Hematopoietic Stem Cells (HSCs) -- Role of Autophagy in Maintenance of Neural Stem Cells -- Role of Autophagy in Maintenance of Muscle Stem Cells -- Role of Autophagy in Maintenance of Bone Marrow Derived Mesenchymal Stem Cells (BMSCs) -- Role of Autophagy in Maintenance of Hepatic Progenitor Cells -- Role of Autophagy in Maintenance of Intestinal Stem Cells (ISCs) -- Autophagy and Stem Cell Differentiation -- Role of Autophagy in the Differentiation of HSCs -- Role of Autophagy in the Differentiation of NSCs -- Role of Autophagy in the Differentiation of Cardiac Stem Cells -- Role of Autophagy in Adipocyte Formation from MSCs -- Role of Autophagy in Osteoclastogenesis -- Role of Autophagy During Embryogenesis -- Conclusion -- References. ; 3 Autophagy in Embryonic Stem Cells and Neural Stem Cells -- Introduction -- Embryonic Stem Cells -- Autophagy in ESCs and During Embryogenesis: Evidence and Importance -- Specific Roles of Autophagy in ESCs -- Autophagy and Proteostasis in ESCs -- Autophagy and Pluripotency Factor Turnover -- Mitophagy in ESCs -- Midbody Ring, Autophagy, and ESCs -- Regulation of Autophagy in ESCs -- Autophagy and Neural Stem Cells -- Neural Stem Cells -- Evidence for Autophagy in Neural Stem Cells -- Implications of Autophagy Defects in Development and Disease -- Conclusions and Outlook -- References -- 4 Autophagy in Germline Stem Cells -- Overview of Autophagy -- Overview of GSCs in Model Organisms -- Perturbed Autophagy Affects Fertility -- Autophagy and Signaling in GSCs -- Autophagy, Lipid Metabolism, and Germline Stem Cells -- Autophagy and Organelle Homeostasis in GSCs -- Autophagy in Programmed Cell Death and Germline Development -- Conclusions -- References -- 5 The Role of Autophagy in the Regulation of Hematopoietic Stem Cells -- Introduction -- Autophagy -- Types of Autophagy -- Microautophagy -- Chaperone-Mediated Autophagy (CMA) -- Macroautophagy -- Autophagy and Stem Cells -- Hematopoietic Stem Cells -- Neural Stem Cells -- Muscle Stem Cells -- Induced Pluripotent Stem Cells -- Cancer Stem Cells -- Autophagy and Hematopoiesis -- Hematopoiesis -- Role of Autophagy in the Ontogeny of the Hematopoietic System -- Role of Autophagy in Hematopoietic Stem Cell Fates -- Autophagy in HSC Quiescence -- Autophagy in HSC Self-renewal -- Autophagy in HSC Differentiation -- Role of Autophagy in HSC Aging -- Role of Autophagy in Niche-Mediated Regulation of Hematopoietic Stem Cells -- Role of Autophagy in Hematological Disorders -- Acute Myeloid Leukemia (AML) -- Myelodysplastic Syndrome (MDS) -- Chronic Myeloid Leukemia (CML) -- Lymphoid Malignancies. ; Final Remarks -- References -- 6 Autophagy in Muscle Stem Cells -- Introduction -- Skeletal Muscle Architecture -- Satellite Cells: Muscle-Resident Stem Cells -- The Role of Satellite Cells -- Myogenesis: Quiescence, Activation, Proliferation, Differentiation, and Self-renewal -- Satellite Cells Contribute to Muscle Health -- Autophagy in Skeletal Muscle -- Basal Autophagy is Required to Maintain Muscle Mass -- Role of Selective Autophagy in Muscle Homeostasis -- Autophagy in Muscle Regeneration and Exercise -- Autophagy in Muscle Health -- Autophagy in Muscle Stem Cells -- Homeostatic Maintenance of Muscle Stem Cells -- Autophagy in Satellite Cells is Under Circadian Regulation -- Quiescent Satellite Cells Exist in Two Distinct Metabolic States -- Contribution of Autophagy in Satellite Cell Activation -- Autophagy Prevents Apoptosis in Satellite Cells -- Satellite Cell Function and Regenerative Capacity -- The Role of mTOR Signaling in Myogenesis -- Coordination of Myogenic Differentiation and p53-Dependent Autophagy -- Mitophagy is Required for Mitochondrial Biogenesis and Myogenesis -- Conclusion -- References -- 7 Autophagy in the Intestinal Stem Cells -- Introduction -- The Role of Autophagy in Intestinal Stem Cell Maintenance and Proliferation -- Role of Autophagy in Intestinal Stem Cell Differentiation -- Insects as Model Organisms in Autophagy Studies in Intestinal Stem Cells -- Pathologies Associated with Autophagy in Intestinal Stem Cells -- Concluding Remarks -- References -- 8 The Autophagy Lysosomal Pathway: Friend or Foe in Adult Neural Stem Cells? -- Introduction -- Neural Stem Cells and Neurogenesis in the Adult Mammalian Brain -- Adult Neural Stem Cell Niches and the Neurogenic Cascade -- The Quiescent State of Adult Neural Stem Cells -- Autophagy, Neural Stem Cells and Adult Neurogenesis. ; The Autophagy Lysosomal Pathway in the Adult Neurogenic Niches -- The Autophagy Lysosomal Pathway in Adult NSC Quiescence -- The Autophagy Lysosomal Pathway in the Autophagic Cell Death of Adult NSCs -- Concluding Remarks -- References -- 9 Autophagy in Mesenchymal Stem Cell-Based Therapy -- Introduction -- Autophagy-An Intracellular Mechanism for the Restoration of Cell Energy -- Autophagy-Dependent Regulation of Stemness and Differentiation Potential of MSCs -- Activation of Autophagy as New Approach for Attenuating Apoptosis of Transplanted MSCs -- MSCs Modulate Autophagy in Parenchymal and Immune Cells Affecting Progression of Degenerative and Inflammatory Diseases -- Modulation of Autophagy as New Approach for Enhancement of MSCs' Immunosuppressive Properties -- Autophagy Improves the Pro-angiogenic Properties of MSCs -- Conclusions -- References -- 10 Autophagic Control of Stem Cells Differentiation into Osteogenic Lineage-Implications in Bone Disorders -- Introduction -- Autophagic Regulation of Embryonic Development -- Autophagy During Embryogenesis -- Autophagy in ESCs -- Autophagy in Skeletogenesis -- Regulation of Stem Cells Characteristics by Autophagy -- Autophagy in Differentiation Fate of Stem Cells -- Autophagic Regulation of Osteogenic Differentiation of Stem Cells -- Implications in Bone Disorders -- Autophagic Dysregulation in Osteoporosis -- Autophagic Dysregulation in Arthritis -- Conclusion and Final Remarks -- References -- 11 Autophagy in Cancer Metastasis -- Introduction -- Cancer Metastasis -- Invasion and Migration -- Intravasation -- Survival in the Circulation -- Extravasation -- Colonization -- Autophagy in Cancer Metastasis -- Role of Autophagy in Regulating EMT -- Autophagy In Inducing Resistance To Anoikis -- Role of Autophagy in Governing Tumour Cell Motility. ; Autophagy in Regulating Tumour Cell Dormancy and Therapy Resistance -- Involvement of Autophagy During Tumour Immune Surveillance -- Role of Autophagy in Other Tumour Microenvironment Activities -- Autophagy in Cancer Therapeutics -- Summary -- References -- Index.
• Titolo autorizzato: Autophagy in stem cell maintenance and differentiation
• ISBN: 3-031-17362-7
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9910629289703321
• Lo trovi qui: Univ. Federico II
• Serie: Stem Cell Biology and Regenerative Medicine