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010   $a3-031-17362-7
024 7 $a10.1007/978-3-031-17362-2
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035   $a(Au-PeEL)EBL7133722
035   $a(CKB)25299357700041
035   $a(PPN)266350275
035   $a(DE-He213)978-3-031-17362-2
035   $a(OCoLC)1351196151
035   $a(EXLCZ)9925299357700041
100   $a20221108d2023      u|         0
101 0 $aeng
135   $aurcnu||||||||
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 10$aAutophagy in Stem Cell Maintenance and Differentiation /$fedited by Bhupendra V. Shravage, Kursad Turksen
205   $a1st ed. 2023.
210  1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2023.
215   $a1 online resource (290 pages)
225 1 $aStem Cell Biology and Regenerative Medicine,$x2196-8993 ;$v73
311 08$aPrint version: Shravage, Bhupendra V. Autophagy in Stem Cell Maintenance and Differentiation Cham : Springer International Publishing AG,c2022 9783031173615 
320   $aIncludes bibliographical references and index.
327   $aAssays for monitoring autophagy in stem cells -- Autophagy in Stem Cell Maintenance and Differentiation -- Autophagy in Embryonic stem cells and Neural stem cells -- Autophagy in Germline Stem Cells -- The role of autophagy in the regulation of hematopoietic stem cells -- Autophagy in Muscle Stem Cells -- Autophagy in Intestinal Stem Cells -- The autophagy lysosomal pathway: friend or foe in adult neural stem cells? -- Autophagy in Mesenchymal Stem Cell-based therapy -- Autophagic control of stem cells differentiation into osteogenic lineage- Implications in bone disorders -- Autophagy in Cancer Metastasis.
330   $aThis book covers a wide range of topics that illustrate the various functions of autophagy in stem cells and offers insights on the mechanisms by which autophagy can regulate stem-cell self-renewal and facilitate specific differentiation programs. Stem cells are unique cells present in most multicellular animals and are essential for their survival. They have two unique properties: the ability to self-renew and the ability to differentiate into one or more cell types. These characteristics of stem cells have found immense therapeutic potential in regenerative medicine. Autophagy is a crucial membrane trafficking pathway that is essential for maintaining cellular homeostasis that involves sequestration of non-functional proteins, protein aggregates and damaged organelles in double-membraned vesicles called autophagosomes, which are subsequently targeted to the lysosome for degradation. The primary aim of this book is to provide knowledge of recent developments in our understandingof the role of autophagy in stem cells, including germline stem cells. Autophagy is considered a promising target for many diseases. Significant efforts are being developed to identify specific modulators of autophagy, which will aid in designing combinatorial therapeutic strategies that will allow significant improvements in regenerative medicine.
410  0$aStem Cell Biology and Regenerative Medicine,$x2196-8993 ;$v73
606   $aCancer
606   $aStem cells
606   $aCytology
606   $aDevelopmental biology
606   $aCancer Stem Cells
606   $aCell Biology
606   $aDevelopmental Biology and Stem Cells
615  0$aCancer.
615  0$aStem cells.
615  0$aCytology.
615  0$aDevelopmental biology.
615 14$aCancer Stem Cells.
615 24$aCell Biology.
615 24$aDevelopmental Biology and Stem Cells.
676   $a050
676   $a616.02774
702   $aShravage$b Bhupendra V.
702   $aTurksen$b Kursad
801  0$bMiAaPQ
801  1$bMiAaPQ
801  2$bMiAaPQ
906   $aBOOK
912   $a9910629289703321
996   $aAutophagy in stem cell maintenance and differentiation$93066910
997   $aUNINA