Vaccines and autoimmunity / / edited by Yehuda Shoenfeld and Nancy Agmon-Levin

• Pubblicazione: Hoboken, New Jersey : , : John Wiley & Sons, , [2015]; ©2015
• Descrizione fisica: 1 online resource (394 p.)
• Disciplina: 614.47
• Soggetto topico: Vaccination; Immunological adjuvants; Autoimmunity
• Persona (resp. second.): ShoenfeldYehuda <1948->; Agmon-LevinNancy
• Note generali: Description based upon print version of record.
• Nota di bibliografia: Includes bibliographical references at the end of each chapters and index.
• Nota di contenuto: Cover; Title Page; Copyright; Contents; Contributors; Chapter Introduction; References; Part I Mosaic of Autoimmunity; Chapter 1 Role of Adjuvants in Infection and Autoimmunity; Introduction; The different types of adjuvants; Aluminum salts; Oil-based adjuvants; Virosomes; Novel and experimental adjuvants; Mechanisms of adjuvanticity; Adjuvants and the adaptive and innate immune response; Adjuvants and TLRs; Mechanisms of adjuvant adverse effects; Autoimmunity and environmental/natural adjuvants; Adjuvant-related diseases; Mineral oils as a cause of autoimmunity ; Human adjuvant disease, silicone as an adjuvant, and connective tissue diseasesMacrophagic myofasciitis and Gulf War syndrome; Autoimmune (autoinflammatory) syndrome induced by adjuvants - ASIA; Conclusions; References; Chapter 2 Infections as Adjuvants for Autoimmunity: The Adjuvant Effect; Introduction; The adjuvant effect; Innate immune pattern recognition of pathogens and adjuvants; Innate immune response mediates the adjuvant effect; Viral infection as adjuvant for autoimmunity: evidence from Coxsackievirus-induced myocarditis; ""Adjuvant disease"" ; Harnessing the adjuvant effect and autoimmunity against cancerConclusions; Acknowledgments; References; Chapter 3 Experimental Models of Adjuvants; Adjuvant models; Murine models; Rats; Mice; Salmon; Rabbits; Swine; Primates; Conclusions; References; Chapter 4 Answers to Common Misconceptions Regarding the Toxicity of Aluminum Adjuvants in Vaccines; Introduction; Al and neurological disorders; Al as adjuvant in vaccines; How is the safety of Al regulated?; Dietary versus vaccine-derived Al: is there a difference?; Long-term persistence of Al adjuvants in the body and its effects ; Al's activation of the NLRP3 inflammasome pathway and its role in autoimmune-inflammatory diseasesAl body burden and the health risks associated with life-long exposure to Al adjuvants; Conclusions; Acknowledgments; References; Chapter 5 Allergy and Autoimmunity Caused by Metals: A Unifying Concept; Introduction; Delayed-type hypersensitivity; The allergic and autoimmune effects of metals; Mercury; Gold; Nickel; Aluminum; Conclusions; References; Chapter 6 Genetics and Vaccinology; Introduction; Brief history of vaccinology; Vaccine response and genetics; Epidemiology and genetics ; Polymorphism of the HLA regionNon-HLA genetic polymorphisms and vaccine response; Conclusions; References; Chapter 7 Silicone and Autoimmune/Inflammatory Syndrome Induced by Adjuvants (ASIA); Introduction; Silicone; Autoimmune/inflammatory syndrome induced by adjuvants (ASIA); Silicone and autoimmunity; Local adverse effects of silicone; The systemic influence of silicone; Antibody response following silicone exposure; Silicone and defined autoimmune diseases; Silicone and scleroderma; Silicone and nondefined autoimmune phenomena; Conclusions; References ; Chapter 8 Silicone Breast Implants and Autoimmune/Inflammatory Syndrome induced by Adjuvants (ASIA): A Literature Search
• Sommario/riassunto: In light of the discovery of Autoimmune Syndrome Induced by Adjuvants, or ASIA, Vaccines and Autoimmunity explores the role of adjuvants - specifically aluminum in different vaccines - and how they can induce diverse autoimmune clinical manifestations in genetically prone individuals. Vaccines and Autoimmunity is divided into three sections; the first contextualizes the role of adjuvants in the framework of autoimmunity, covering the mechanism of action of adjuvants, experimental models of adjuvant induced autoimmune diseases, infections as adjuvants, the Gulf War Syndrome, sick-building s
• Titolo autorizzato: Vaccines and autoimmunity
• ISBN: 1-118-66349-7; 1-118-66372-1
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9910140641403321
• Lo trovi qui: Univ. Federico II