LEADER 05488nam 2200697 450 001 9910140641403321 005 20220307191034.0 010 $a1-118-66349-7 010 $a1-118-66372-1 035 $a(CKB)2670000000617073 035 $a(EBL)1895533 035 $a(SSID)ssj0001483120 035 $a(PQKBManifestationID)12535375 035 $a(PQKBTitleCode)TC0001483120 035 $a(PQKBWorkID)11428795 035 $a(PQKB)11169060 035 $a(PQKBManifestationID)16048533 035 $a(PQKB)23893372 035 $a(DLC) 2015007410 035 $a(MiAaPQ)EBC1895533 035 $a(MiAaPQ)EBC5499475 035 $a(Au-PeEL)EBL5499475 035 $a(PPN)190016507 035 $a(EXLCZ)992670000000617073 100 $a20220307d2015 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aVaccines and autoimmunity /$fedited by Yehuda Shoenfeld and Nancy Agmon-Levin 210 1$aHoboken, New Jersey :$cJohn Wiley & Sons,$d[2015] 210 4$dİ2015 215 $a1 online resource (394 p.) 300 $aDescription based upon print version of record. 311 $a1-118-66353-5 311 $a1-118-66343-8 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aCover; Title Page; Copyright; Contents; Contributors; Chapter Introduction; References; Part I Mosaic of Autoimmunity; Chapter 1 Role of Adjuvants in Infection and Autoimmunity; Introduction; The different types of adjuvants; Aluminum salts; Oil-based adjuvants; Virosomes; Novel and experimental adjuvants; Mechanisms of adjuvanticity; Adjuvants and the adaptive and innate immune response; Adjuvants and TLRs; Mechanisms of adjuvant adverse effects; Autoimmunity and environmental/natural adjuvants; Adjuvant-related diseases; Mineral oils as a cause of autoimmunity 327 $aHuman adjuvant disease, silicone as an adjuvant, and connective tissue diseasesMacrophagic myofasciitis and Gulf War syndrome; Autoimmune (autoinflammatory) syndrome induced by adjuvants - ASIA; Conclusions; References; Chapter 2 Infections as Adjuvants for Autoimmunity: The Adjuvant Effect; Introduction; The adjuvant effect; Innate immune pattern recognition of pathogens and adjuvants; Innate immune response mediates the adjuvant effect; Viral infection as adjuvant for autoimmunity: evidence from Coxsackievirus-induced myocarditis; ""Adjuvant disease"" 327 $aHarnessing the adjuvant effect and autoimmunity against cancerConclusions; Acknowledgments; References; Chapter 3 Experimental Models of Adjuvants; Adjuvant models; Murine models; Rats; Mice; Salmon; Rabbits; Swine; Primates; Conclusions; References; Chapter 4 Answers to Common Misconceptions Regarding the Toxicity of Aluminum Adjuvants in Vaccines; Introduction; Al and neurological disorders; Al as adjuvant in vaccines; How is the safety of Al regulated?; Dietary versus vaccine-derived Al: is there a difference?; Long-term persistence of Al adjuvants in the body and its effects 327 $aAl's activation of the NLRP3 inflammasome pathway and its role in autoimmune-inflammatory diseasesAl body burden and the health risks associated with life-long exposure to Al adjuvants; Conclusions; Acknowledgments; References; Chapter 5 Allergy and Autoimmunity Caused by Metals: A Unifying Concept; Introduction; Delayed-type hypersensitivity; The allergic and autoimmune effects of metals; Mercury; Gold; Nickel; Aluminum; Conclusions; References; Chapter 6 Genetics and Vaccinology; Introduction; Brief history of vaccinology; Vaccine response and genetics; Epidemiology and genetics 327 $aPolymorphism of the HLA regionNon-HLA genetic polymorphisms and vaccine response; Conclusions; References; Chapter 7 Silicone and Autoimmune/Inflammatory Syndrome Induced by Adjuvants (ASIA); Introduction; Silicone; Autoimmune/inflammatory syndrome induced by adjuvants (ASIA); Silicone and autoimmunity; Local adverse effects of silicone; The systemic influence of silicone; Antibody response following silicone exposure; Silicone and defined autoimmune diseases; Silicone and scleroderma; Silicone and nondefined autoimmune phenomena; Conclusions; References 327 $aChapter 8 Silicone Breast Implants and Autoimmune/Inflammatory Syndrome induced by Adjuvants (ASIA): A Literature Search 330 $aIn light of the discovery of Autoimmune Syndrome Induced by Adjuvants, or ASIA, Vaccines and Autoimmunity explores the role of adjuvants - specifically aluminum in different vaccines - and how they can induce diverse autoimmune clinical manifestations in genetically prone individuals. Vaccines and Autoimmunity is divided into three sections; the first contextualizes the role of adjuvants in the framework of autoimmunity, covering the mechanism of action of adjuvants, experimental models of adjuvant induced autoimmune diseases, infections as adjuvants, the Gulf War Syndrome, sick-building s 606 $aVaccination 606 $aImmunological adjuvants 606 $aAutoimmunity 615 0$aVaccination. 615 0$aImmunological adjuvants. 615 0$aAutoimmunity. 676 $a614.47 702 $aShoenfeld$b Yehuda$f1948- 702 $aAgmon-Levin$b Nancy 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910140641403321 996 $aVaccines and autoimmunity$92072040 997 $aUNINA