New Therapies to Prevent or Cure Auditory Disorders / / edited by Sylvie Pucheu, Kelly E. Radziwon, Richard Salvi

• Pubblicazione: Cham : , : Springer International Publishing : , : Imprint : Springer, , 2020
• Edizione: 1st ed. 2020.
• Descrizione fisica: 1 online resource (VII, 186 p. 29 illus., 25 illus. in color.)
• Disciplina: 617.8
• Soggetto topico: Neurosciences; Otorhinolaryngology; Malalties de l'orella; Medicina preventiva; Terapèutica
• Soggetto genere / forma: Llibres electrònics
• Persona (resp. second.): PucheuSylvie; RadziwonKelly E; SalviRichard
• Nota di bibliografia: Includes bibliographical references.
• Nota di contenuto: Intro -- Introduction -- Contents -- Lifestyle Intervention to Prevent Age-Related Hearing Loss: Calorie Restriction -- 1 Introduction -- 2 Effects of Age on Auditory Function -- 3 Effects of Calorie Restriction on Aging -- 3.1 Types of Calorie Restriction Regimens -- 3.2 Effects of Calorie Restriction on Hearing Loss in Laboratory Animals -- 4 Mechanisms Underlying the Beneficial Effects of CR on AHL -- 4.1 Oxidative Stress -- 4.2 Apoptosis -- 4.3 mtDNA Mutations -- 5 Conclusion -- References -- Noise-Induced Hearing Loss and Drug Therapy: Basic and Translational Science -- 1 Introduction 2 Cochlear Pathology -- 2.1 Oxidative Stress -- 2.2 Cochlear Blood Flow Changes -- 2.3 Apoptotic Cell Death -- 2.4 Mechanical Damage and Stereocilia Injury -- 3 Noise-Induced Deafferentation -- 3.1 Consequences of Synaptopathy -- 4 Auditory Threshold Shift as a Measure of Noise-Induced Hearing Loss -- 4.1 Extended High-Frequency Audiometry -- 5 Effects of Noise on Suprathreshold Measures of Hearing -- 5.1 Speech-in-Noise Testing -- 6 Pharmaceutical Otoprotection from Noise-Induced Hearing Loss -- 6.1 Antioxidants -- 6.2 Steroid Therapy -- 6.3 S-Ketamine and Glutamate Excitotoxicity 6.4 Cell Death and Stress Inhibitors -- 7 Summary -- References -- Review of Ototoxic Drugs and Treatment Strategies for Reducing Hearing Loss -- 1 Significance and Background -- 2 Cisplatin Ototoxicity -- 2.1 Entry of Cisplatin into the Cochlea -- 2.2 Mechanisms Underlying Cisplatin Ototoxicity -- Increased Oxidative Stress -- Promoting Cellular Apoptosis -- Covalent Modification of DNA -- 2.3 Pharmacogenomics of Cisplatin Ototoxicity -- 2.4 Approaches to Treating Cisplatin Ototoxicity -- Relieving Oxidative Stress -- Targeting Cochlear Inflammation Drugs Targeting G Protein-Coupled Receptors for Treating Cisplatin Ototoxicity -- 2.5 Ongoing Clinical Trials for Cisplatin Ototoxicity -- 3 Cyclodextrin-Induced Hearing Loss -- 4 Aminoglycosides -- 4.1 Overview -- 4.2 Studies Showing Hearing Loss -- 4.3 Uptake of Aminoglycosides into the Cochlea -- 4.4 Aminoglycoside Genetic Susceptibility -- 4.5 Preventative Strategies for Ototoxicity -- Antioxidants -- Inhibition of Apoptosis -- Mechanoelectrical Transducer Channel Blockers -- 5 Summary -- References -- Approaches to Regenerate Hair Cell and Spiral Ganglion Neuron in the Inner Ear 1 Introduction -- 1.1 Global Estimates and Impact of Hearing Impairment -- 1.2 Categories of Hearing Loss -- 1.3 Native HCs Regeneration Capacity in Mammals and Non-mammals -- 2 Approaches to Regenerate HCs and SGNs -- 2.1 Gene Therapy -- Cochlear Gene Therapy Vehicles -- 2.2 Key Signaling Pathway Genes for HC Regeneration -- 2.3 Atoh1-Based Gene Therapy -- 2.4 Inactivation of Cell Cycle Inhibitors Based Gene Therapy -- 2.5 Gene Therapy for SGN Regeneration -- 3 Stem Cell Therapy -- 4 Conclusion -- References.
• Sommario/riassunto: This volume focuses on new molecular therapies that aim to prevent specific pathologies of the ear, like age-related hearing loss, noise-induced hearing loss and ototoxicity. The book discusses the regenerative capacity of hair cells in the inner ear, exploring the idea that hair cells’ capacity to regenerate appears “repressed” in adult mammals, but that it will be possible to re-activate regeneration with an appropriate therapeutic approach. The book provides an overview of inflammatory and immune cells in the cochlear lateral wall, the pathways involved in cochlear damage, and their potential as therapeutic targets. It also describes the significant advances in animal models which play an important role in revealing the underlying mechanisms and treatment for tinnitus and hyperacusis. Finally, the book describes two new automatic and robust measures to evaluate hearing loss and tinnitus in preclinical models.
• Titolo autorizzato: New Therapies to Prevent or Cure Auditory Disorders
• ISBN: 3-030-40413-7
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9910409701503321
• Lo trovi qui: Univ. Federico II