LEADER 05922nam 22006135 450 001 9910409701503321 005 20220615110911.0 010 $a3-030-40413-7 024 7 $a10.1007/978-3-030-40413-0 035 $a(CKB)4100000010771006 035 $a(DE-He213)978-3-030-40413-0 035 $a(MiAaPQ)EBC6146505 035 $a(PPN)243229186 035 $a(EXLCZ)994100000010771006 100 $a20200325d2020 u| 0 101 0 $aeng 135 $aurnn#008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aNew Therapies to Prevent or Cure Auditory Disorders /$fedited by Sylvie Pucheu, Kelly E. Radziwon, Richard Salvi 205 $a1st ed. 2020. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2020. 215 $a1 online resource (VII, 186 p. 29 illus., 25 illus. in color.) 311 $a3-030-40412-9 320 $aIncludes bibliographical references. 327 $aIntro -- Introduction -- Contents -- Lifestyle Intervention to Prevent Age-Related Hearing Loss: Calorie Restriction -- 1 Introduction -- 2 Effects of Age on Auditory Function -- 3 Effects of Calorie Restriction on Aging -- 3.1 Types of Calorie Restriction Regimens -- 3.2 Effects of Calorie Restriction on Hearing Loss in Laboratory Animals -- 4 Mechanisms Underlying the Beneficial Effects of CR on AHL -- 4.1 Oxidative Stress -- 4.2 Apoptosis -- 4.3 mtDNA Mutations -- 5 Conclusion -- References -- Noise-Induced Hearing Loss and Drug Therapy: Basic and Translational Science -- 1 Introduction 2 Cochlear Pathology -- 2.1 Oxidative Stress -- 2.2 Cochlear Blood Flow Changes -- 2.3 Apoptotic Cell Death -- 2.4 Mechanical Damage and Stereocilia Injury -- 3 Noise-Induced Deafferentation -- 3.1 Consequences of Synaptopathy -- 4 Auditory Threshold Shift as a Measure of Noise-Induced Hearing Loss -- 4.1 Extended High-Frequency Audiometry -- 5 Effects of Noise on Suprathreshold Measures of Hearing -- 5.1 Speech-in-Noise Testing -- 6 Pharmaceutical Otoprotection from Noise-Induced Hearing Loss -- 6.1 Antioxidants -- 6.2 Steroid Therapy -- 6.3 S-Ketamine and Glutamate Excitotoxicity 6.4 Cell Death and Stress Inhibitors -- 7 Summary -- References -- Review of Ototoxic Drugs and Treatment Strategies for Reducing Hearing Loss -- 1 Significance and Background -- 2 Cisplatin Ototoxicity -- 2.1 Entry of Cisplatin into the Cochlea -- 2.2 Mechanisms Underlying Cisplatin Ototoxicity -- Increased Oxidative Stress -- Promoting Cellular Apoptosis -- Covalent Modification of DNA -- 2.3 Pharmacogenomics of Cisplatin Ototoxicity -- 2.4 Approaches to Treating Cisplatin Ototoxicity -- Relieving Oxidative Stress -- Targeting Cochlear Inflammation Drugs Targeting G Protein-Coupled Receptors for Treating Cisplatin Ototoxicity -- 2.5 Ongoing Clinical Trials for Cisplatin Ototoxicity -- 3 Cyclodextrin-Induced Hearing Loss -- 4 Aminoglycosides -- 4.1 Overview -- 4.2 Studies Showing Hearing Loss -- 4.3 Uptake of Aminoglycosides into the Cochlea -- 4.4 Aminoglycoside Genetic Susceptibility -- 4.5 Preventative Strategies for Ototoxicity -- Antioxidants -- Inhibition of Apoptosis -- Mechanoelectrical Transducer Channel Blockers -- 5 Summary -- References -- Approaches to Regenerate Hair Cell and Spiral Ganglion Neuron in the Inner Ear 1 Introduction -- 1.1 Global Estimates and Impact of Hearing Impairment -- 1.2 Categories of Hearing Loss -- 1.3 Native HCs Regeneration Capacity in Mammals and Non-mammals -- 2 Approaches to Regenerate HCs and SGNs -- 2.1 Gene Therapy -- Cochlear Gene Therapy Vehicles -- 2.2 Key Signaling Pathway Genes for HC Regeneration -- 2.3 Atoh1-Based Gene Therapy -- 2.4 Inactivation of Cell Cycle Inhibitors Based Gene Therapy -- 2.5 Gene Therapy for SGN Regeneration -- 3 Stem Cell Therapy -- 4 Conclusion -- References. 330 $aThis volume focuses on new molecular therapies that aim to prevent specific pathologies of the ear, like age-related hearing loss, noise-induced hearing loss and ototoxicity. The book discusses the regenerative capacity of hair cells in the inner ear, exploring the idea that hair cells? capacity to regenerate appears ?repressed? in adult mammals, but that it will be possible to re-activate regeneration with an appropriate therapeutic approach. The book provides an overview of inflammatory and immune cells in the cochlear lateral wall, the pathways involved in cochlear damage, and their potential as therapeutic targets. It also describes the significant advances in animal models which play an important role in revealing the underlying mechanisms and treatment for tinnitus and hyperacusis. Finally, the book describes two new automatic and robust measures to evaluate hearing loss and tinnitus in preclinical models. 606 $aNeurosciences 606 $aOtolaryngology 606 $aNeurosciences$3https://scigraph.springernature.com/ontologies/product-market-codes/B18006 606 $aOtorhinolaryngology$3https://scigraph.springernature.com/ontologies/product-market-codes/H46007 606 $aMalalties de l'orella$2thub 606 $aMedicina preventiva$2thub 606 $aTerapčutica$2thub 608 $aLlibres electrňnics$2thub 615 0$aNeurosciences. 615 0$aOtolaryngology. 615 14$aNeurosciences. 615 24$aOtorhinolaryngology. 615 7$aMalalties de l'orella 615 7$aMedicina preventiva 615 7$aTerapčutica 676 $a617.8 702 $aPucheu$b Sylvie$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aRadziwon$b Kelly E$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aSalvi$b Richard$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910409701503321 996 $aNew Therapies to Prevent or Cure Auditory Disorders$92523547 997 $aUNINA