Biomolecular Feedback Systems / / Richard M. Murray, Domitilla Del Vecchio
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| Autore: |
Del Vecchio Domitilla
|
| Titolo: |
Biomolecular Feedback Systems / / Richard M. Murray, Domitilla Del Vecchio
|
| Pubblicazione: | Princeton, NJ : , : Princeton University Press, , [2014] |
| ©2015 | |
| Edizione: | Course Book |
| Descrizione fisica: | 1 online resource (287 p.) |
| Disciplina: | 612.8233 |
| Soggetto topico: | Biological control systems |
| Systems biology | |
| Soggetto non controllato: | CLE |
| CME | |
| E. coli | |
| FPE | |
| FokkerАlanck equation | |
| IFFL | |
| activatorвepressor clock | |
| bacterial chemotaxis | |
| basic modeling formalisms | |
| basic probability | |
| biological circuits | |
| biological mechanisms | |
| biological noise | |
| biological oscillations | |
| biological systems | |
| biomolecular feedback systems | |
| biomolecular reactions | |
| biomolecular systems | |
| cellular resources | |
| chemical Langevin equation | |
| chemical master equation | |
| circuit behavior | |
| control theory | |
| core processes | |
| design tradeoffs | |
| deterministic models | |
| differential equations | |
| dynamical systems theory | |
| dynamical systems | |
| engineering solutions | |
| equilibria | |
| equilibrium points | |
| feedback control theory | |
| feedback principles | |
| gene circuits | |
| host organism | |
| incoherent feedforward loop | |
| independent circuits | |
| interconnecting components | |
| limit cycles | |
| loading effects | |
| mean behavior | |
| modeling formalism | |
| modular interconnection of circuits | |
| negative autoregulation | |
| noise amplification | |
| parameter uncertainty | |
| reaction-rate equation | |
| repressilator | |
| retroactivity attenuation | |
| robustness | |
| signal transduction circuits | |
| simple dynamical models | |
| stochastic behavior | |
| stochastic modeling | |
| stochastic models | |
| stochastic processes | |
| synthetic biology | |
| synthetic circuits | |
| systems biology | |
| time scales | |
| toggle switch | |
| Persona (resp. second.): | MurrayRichard M. |
| Note generali: | Description based upon print version of record. |
| Nota di bibliografia: | Includes bibliographical references and index. |
| Nota di contenuto: | Frontmatter -- Contents -- Preface -- Chapter 1. Introductory Concepts -- Chapter 2. Dynamic Modeling of Core Processes -- Chapter 3. Analysis of Dynamic Behavior -- Chapter 4. Stochastic Modeling and Analysis -- Chapter 5. Biological Circuit Components -- Chapter 6. Interconnecting Components -- Chapter 7. Design Tradeoffs -- Bibliography -- Index |
| Sommario/riassunto: | This book provides an accessible introduction to the principles and tools for modeling, analyzing, and synthesizing biomolecular systems. It begins with modeling tools such as reaction-rate equations, reduced-order models, stochastic models, and specific models of important core processes. It then describes in detail the control and dynamical systems tools used to analyze these models. These include tools for analyzing stability of equilibria, limit cycles, robustness, and parameter uncertainty. Modeling and analysis techniques are then applied to design examples from both natural systems and synthetic biomolecular circuits. In addition, this comprehensive book addresses the problem of modular composition of synthetic circuits, the tools for analyzing the extent of modularity, and the design techniques for ensuring modular behavior. It also looks at design trade-offs, focusing on perturbations due to noise and competition for shared cellular resources.Featuring numerous exercises and illustrations throughout, Biomolecular Feedback Systems is the ideal textbook for advanced undergraduates and graduate students. For researchers, it can also serve as a self-contained reference on the feedback control techniques that can be applied to biomolecular systems.Provides a user-friendly introduction to essential concepts, tools, and applicationsCovers the most commonly used modeling methodsAddresses the modular design problem for biomolecular systemsUses design examples from both natural systems and synthetic circuitsSolutions manual (available only to professors at press.princeton.edu)An online illustration package is available to professors at press.princeton.edu |
| Titolo autorizzato: | Biomolecular Feedback Systems |
| ISBN: | 1-4008-5050-9 |
| Formato: | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione: | Inglese |
| Record Nr.: | 9910832978603321 |
| Lo trovi qui: | Univ. Federico II |
| Opac: | Controlla la disponibilità qui |