04004nam 22006735 450 991083297860332120190523123322.09781400850501140085050910.1515/9781400850501(CKB)2550000001352414(EBL)1724880(OCoLC)890441141(SSID)ssj0001335392(PQKBManifestationID)12569659(PQKBTitleCode)TC0001335392(PQKBWorkID)11288798(PQKB)11483496(MiAaPQ)EBC1724880(StDuBDS)EDZ0001756476(DE-B1597)453998(OCoLC)984682158(DE-B1597)9781400850501(Perlego)736046(ScCtBLL)efa550f9-aaea-4e06-b4ca-613b47f7d240(OCoLC)1000351223(EXLCZ)99255000000135241420190523d2014 fg engur|n|---|||||txtccrBiomolecular Feedback Systems /Richard M. Murray, Domitilla Del VecchioCourse BookPrinceton, NJ : Princeton University Press, [2014]©20151 online resource (287 p.)Description based upon print version of record.9780691161532 0691161534 9781322111742 132211174X Includes bibliographical references and index.Frontmatter -- Contents -- Preface -- Chapter 1. Introductory Concepts -- Chapter 2. Dynamic Modeling of Core Processes -- Chapter 3. Analysis of Dynamic Behavior -- Chapter 4. Stochastic Modeling and Analysis -- Chapter 5. Biological Circuit Components -- Chapter 6. Interconnecting Components -- Chapter 7. Design Tradeoffs -- Bibliography -- IndexThis book provides an accessible introduction to the principles and tools for modeling, analyzing, and synthesizing biomolecular systems. It begins with modeling tools such as reaction-rate equations, reduced-order models, stochastic models, and specific models of important core processes. It then describes in detail the control and dynamical systems tools used to analyze these models. These include tools for analyzing stability of equilibria, limit cycles, robustness, and parameter uncertainty. Modeling and analysis techniques are then applied to design examples from both natural systems and synthetic biomolecular circuits. In addition, this comprehensive book addresses the problem of modular composition of synthetic circuits, the tools for analyzing the extent of modularity, and the design techniques for ensuring modular behavior. It also looks at design trade-offs, focusing on perturbations due to noise and competition for shared cellular resources.Featuring numerous exercises and illustrations throughout, Biomolecular Feedback Systems is the ideal textbook for advanced undergraduates and graduate students. For researchers, it can also serve as a self-contained reference on the feedback control techniques that can be applied to biomolecular systems.Provides a user-friendly introduction to essential concepts, tools, and applicationsCovers the most commonly used modeling methodsAddresses the modular design problem for biomolecular systemsUses design examples from both natural systems and synthetic circuitsSolutions manual (available only to professors at press.princeton.edu)An online illustration package is available to professors at press.princeton.eduBiological control systemsSystems biologyBiological control systems.Systems biology.612.8233Del Vecchio Domitilla, 1725679Murray Richard M., DE-B1597DE-B1597BOOK9910832978603321Biomolecular Feedback Systems4129880UNINA