The Nociceptin/Orphanin FQ Peptide Receptor / / edited by Mei-Chuan Ko, Girolamo Caló
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| Titolo: |
The Nociceptin/Orphanin FQ Peptide Receptor / / edited by Mei-Chuan Ko, Girolamo Caló
|
| Pubblicazione: | Cham : , : Springer International Publishing : , : Imprint : Springer, , 2019 |
| Edizione: | 1st ed. 2019. |
| Descrizione fisica: | 1 online resource (412 pages) |
| Disciplina: | 599.0188 |
| Soggetto topico: | Pharmacology |
| Neurosciences | |
| Anesthesiology | |
| Pain medicine | |
| Psychopharmacology | |
| Pharmacology/Toxicology | |
| Pain Medicine | |
| Persona (resp. second.): | KoMei-Chuan |
| CalóGirolamo | |
| Nota di contenuto: | PART I. The N/OFQ-NOP Receptor System -- 1. The History of N/OFQ and the NOP Receptor -- 2. NOP-Targeted Peptide Ligands -- 3. NOP-Targeted Nonpeptide Ligands -- 4. Pharmacological Assays for Investigating the NOP Receptor -- 5. Electrophysiological Actions of N/OFQ -- 6. NOP Receptor Signaling Cascades -- 7.Regulation of the Genes Encoding the ppN/OFQ and NOP Receptor -- PART II. Biological Actions of NOP Ligands -- 8.NOP-Related Mechanisms in Pain and Analgesia -- 9. NOP-Related Mechanisms in Substance Use Disorders -- 10. NOP Receptor Ligands and Parkinson’s Disease -- 11. NOP Ligands for the Treatment of Anxiety and Mood Disorders -- 12. The Nociceptin/Orphanin FQ System and the Regulation of Memory -- 13. N/OFQ-NOP System in Food Intake -- 14. N/OFQ-NOP System in Peripheral and Central Immunomodulation -- 15. N/OFQ-NOP System and Airways -- 16. Effects of NOP-Related Ligands in Nonhuman Primates -- PART III. First Clinical Studies with NOP Ligands -- 17. Nociceptin/Orphanin FQ and Urinary Bladder -- 18. Cebranopadol: A Novel First-in-Class Potent Analgesic Acting via NOP and Opioid Receptors -- 19. Therapeutic Approaches for NOP Receptor Antagonists in Neurobehavioral Disorders: Clinical Studies in Major Depressive Disorder and Alcohol Use Disorder with BTRX-246040 (LY2940094) -- 20. Correction to: Electrophysiological Actions of N/OFQ. |
| Sommario/riassunto: | The aim of this book is not only to introduce readers with a broad spectrum of biological actions of the NOP receptor, but also to feature a detailed look at the N/OFQ-NOP receptor system, medicinal chemistry, pharmacology, and clinical data of NOP-targeted ligands. This special volume book - for the first time focusing on the NOP receptor - is designed to serve as a useful reference, stimulate more research on the N/OFQ-NOP receptor system, and lead to more development of NOP-related ligands for several therapeutic applications. |
| Titolo autorizzato: | The Nociceptin |
| ISBN: | 3-030-20186-4 |
| Formato: | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione: | Inglese |
| Record Nr.: | 9910349292803321 |
| Lo trovi qui: | Univ. Federico II |
| Opac: | Controlla la disponibilità qui |
Serie:
Handbook of Experimental Pharmacology, . 0171-2004 ; ; 254