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010   $a3-030-20186-4
024 7 $a10.1007/978-3-030-20186-9
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035   $a(MiAaPQ)EBC5826032
035   $a(DE-He213)978-3-030-20186-9
035   $a(PPN)238485471
035   $a(EXLCZ)994100000008702199
100   $a20190713d2019      u|         0
101 0 $aeng
135   $aurcnu||||||||
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 14$aThe Nociceptin/Orphanin FQ Peptide Receptor /$fedited by Mei-Chuan Ko, Girolamo Caló
205   $a1st ed. 2019.
210  1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2019.
215   $a1 online resource (412 pages)
225 1 $aHandbook of Experimental Pharmacology,$x0171-2004 ;$v254
311   $a3-030-20185-6 
327   $aPART I. The N/OFQ-NOP Receptor System -- 1. The History of N/OFQ and the NOP Receptor -- 2. NOP-Targeted Peptide Ligands -- 3. NOP-Targeted Nonpeptide Ligands -- 4. Pharmacological Assays for Investigating the NOP Receptor -- 5. Electrophysiological Actions of N/OFQ -- 6. NOP Receptor Signaling Cascades -- 7.Regulation of the Genes Encoding the ppN/OFQ and NOP Receptor -- PART II. Biological Actions of NOP Ligands -- 8.NOP-Related Mechanisms in Pain and Analgesia -- 9. NOP-Related Mechanisms in Substance Use Disorders -- 10. NOP Receptor Ligands and Parkinson?s Disease -- 11. NOP Ligands for the Treatment of Anxiety and Mood Disorders -- 12. The Nociceptin/Orphanin FQ System and the Regulation of Memory -- 13. N/OFQ-NOP System in Food Intake -- 14. N/OFQ-NOP System in Peripheral and Central Immunomodulation -- 15. N/OFQ-NOP System and Airways -- 16. Effects of NOP-Related Ligands in Nonhuman Primates -- PART III. First Clinical Studies with NOP Ligands -- 17. Nociceptin/Orphanin FQ and Urinary Bladder -- 18. Cebranopadol: A Novel First-in-Class Potent Analgesic Acting via NOP and Opioid Receptors -- 19. Therapeutic Approaches for NOP Receptor Antagonists in Neurobehavioral Disorders: Clinical Studies in Major Depressive Disorder and Alcohol Use Disorder with BTRX-246040 (LY2940094) -- 20. Correction to: Electrophysiological Actions of N/OFQ.
330   $aThe aim of this book is not only to introduce readers with a broad spectrum of biological actions of the NOP receptor, but also to feature a detailed look at the N/OFQ-NOP receptor system, medicinal chemistry, pharmacology, and clinical data of NOP-targeted ligands. This special volume book - for the first time focusing on the NOP receptor - is designed to serve as a useful reference, stimulate more research on the N/OFQ-NOP receptor system, and lead to more development of NOP-related ligands for several therapeutic applications.
410  0$aHandbook of Experimental Pharmacology,$x0171-2004 ;$v254
606   $aPharmacology
606   $aNeurosciences
606   $aAnesthesiology
606   $aPain medicine
606   $aPsychopharmacology
606   $aPharmacology/Toxicology$3https://scigraph.springernature.com/ontologies/product-market-codes/B21007
606   $aNeurosciences$3https://scigraph.springernature.com/ontologies/product-market-codes/B18006
606   $aAnesthesiology$3https://scigraph.springernature.com/ontologies/product-market-codes/H13001
606   $aPain Medicine$3https://scigraph.springernature.com/ontologies/product-market-codes/H47003
606   $aPsychopharmacology$3https://scigraph.springernature.com/ontologies/product-market-codes/H53010
615  0$aPharmacology.
615  0$aNeurosciences.
615  0$aAnesthesiology.
615  0$aPain medicine.
615  0$aPsychopharmacology.
615 14$aPharmacology/Toxicology.
615 24$aNeurosciences.
615 24$aAnesthesiology.
615 24$aPain Medicine.
615 24$aPsychopharmacology.
676   $a599.0188
676   $a599.0188
702   $aKo$b Mei-Chuan$4edt$4http://id.loc.gov/vocabulary/relators/edt
702   $aCaló$b Girolamo$4edt$4http://id.loc.gov/vocabulary/relators/edt
906   $aBOOK
912   $a9910349292803321
996   $aThe Nociceptin$91918771
997   $aUNINA