A Network-Based Approach to Cell Metabolism : From Structure to Flux Balances / / by Oriol Güell
(Visualizza in formato marc)
(Visualizza in BIBFRAME)
| Autore: |
Güell Oriol
|
| Titolo: |
A Network-Based Approach to Cell Metabolism : From Structure to Flux Balances / / by Oriol Güell
|
| Pubblicazione: | Cham : , : Springer International Publishing : , : Imprint : Springer, , 2017 |
| Edizione: | 1st ed. 2017. |
| Descrizione fisica: | 1 online resource (151 pages) : illustrations (some color) |
| Disciplina: | 574.8761 |
| Soggetto topico: | Biochemical engineering |
| Systems biology | |
| Biological systems | |
| Chemistry, Physical and theoretical | |
| Biochemical Engineering | |
| Systems Biology | |
| Physical Chemistry | |
| Note generali: | "Doctoral Thesis accepted by University of Barcelona, Barcelona, Spain." |
| Nota di bibliografia: | Includes bibliographical references at the end of each chapters. |
| Nota di contenuto: | Cellular Metabolism at the Systems Level -- Methods and Data -- Structural Knockout Cascades in Metabolic Networks -- Effects of Reaction Knockouts on Steady States of Metabolism -- Detection of Evolution and Adaptation Fingerprints in Metabolic Networks -- Assessing FBA Optimal States in the Feasible Flux Phenotypic Space -- Conclusions. |
| Sommario/riassunto: | This thesis uses a systems-level approach to study the cellular metabolism, unveiling new mechanisms and responses that were impossible to reach with traditional reductionists procedures. The results reported here have a potential application in areas like metabolic engineering and disease treatment. They could also be used in determining the accuracy of the gene essentiality of new genome-scale reconstructions. Different methods and techniques, within the contexts of Systems Biology and the field known as Complex Networks Analysis have been applied in this work to show different features of the robustness of metabolic networks. The specific issues addressed here range from pure topological aspec ts of the networks themselves to the balance of biochemical fluxes. . |
| Titolo autorizzato: | A Network-Based Approach to Cell Metabolism |
| ISBN: | 3-319-64000-3 |
| Formato: | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione: | Inglese |
| Record Nr.: | 9910254154403321 |
| Lo trovi qui: | Univ. Federico II |
| Opac: | Controlla la disponibilità qui |
Serie:
Springer Theses, Recognizing Outstanding Ph.D. Research, . 2190-5053