03586nam 22006375 450 991025415440332120200705030038.03-319-64000-310.1007/978-3-319-64000-6(CKB)3710000001631622(MiAaPQ)EBC4978965(DE-He213)978-3-319-64000-6(PPN)203851579(EXLCZ)99371000000163162220170816d2017 u| 0engurcnu||||||||rdacontentrdamediardacarrierA Network-Based Approach to Cell Metabolism From Structure to Flux Balances /by Oriol Güell1st ed. 2017.Cham :Springer International Publishing :Imprint: Springer,2017.1 online resource (151 pages) illustrations (some color)Springer Theses, Recognizing Outstanding Ph.D. Research,2190-5053"Doctoral Thesis accepted by University of Barcelona, Barcelona, Spain."3-319-63999-4 Includes bibliographical references at the end of each chapters.Cellular Metabolism at the Systems Level -- Methods and Data -- Structural Knockout Cascades in Metabolic Networks -- Effects of Reaction Knockouts on Steady States of Metabolism -- Detection of Evolution and Adaptation Fingerprints in Metabolic Networks -- Assessing FBA Optimal States in the Feasible Flux Phenotypic Space -- Conclusions.This thesis uses a systems-level approach to study the cellular metabolism, unveiling new mechanisms and responses that were impossible to reach with traditional reductionists procedures. The results reported here have a potential application in areas like metabolic engineering and disease treatment. They could also be used in determining the accuracy of the gene essentiality of new genome-scale reconstructions. Different methods and techniques, within the contexts of Systems Biology and the field known as Complex Networks Analysis have been applied in this work to show different features of the robustness of metabolic networks. The specific issues addressed here range from pure topological aspec ts of the networks themselves to the balance of biochemical fluxes.    .Springer Theses, Recognizing Outstanding Ph.D. Research,2190-5053Biochemical engineeringSystems biologyBiological systemsChemistry, Physical and theoreticalBiochemical Engineeringhttps://scigraph.springernature.com/ontologies/product-market-codes/C12029Systems Biologyhttps://scigraph.springernature.com/ontologies/product-market-codes/L15010Systems Biologyhttps://scigraph.springernature.com/ontologies/product-market-codes/P27050Physical Chemistryhttps://scigraph.springernature.com/ontologies/product-market-codes/C21001Biochemical engineering.Systems biology.Biological systems.Chemistry, Physical and theoretical.Biochemical Engineering.Systems Biology.Systems Biology.Physical Chemistry.574.8761Güell Oriolauthttp://id.loc.gov/vocabulary/relators/aut767488MiAaPQMiAaPQMiAaPQBOOK9910254154403321A Network-Based Approach to Cell Metabolism2281684UNINA