Cellular proteins and their fatty acids in health and disease [[electronic resource] /] / Asim K. Duttaroy and Friedrich Spener (eds.)

• Pubblicazione: Weinheim, : Wiley-VCH, c2003
• Descrizione fisica: 1 online resource (484 p.)
• Disciplina: 572.6; 599.019247
• Soggetto topico: Fatty acid-binding proteins
• Soggetto genere / forma: Electronic books.
• Altri autori: DuttaroyAsim K SpenerF (Friedrich)
• Note generali: Description based upon print version of record.
• Nota di bibliografia: Includes bibliographical references and index.
• Nota di contenuto: Cellular Proteins and Their Fatty Acids in Health and Disease; Preface; Contents; List of Contributors; Part 1 The Molecular Basis of Protein-Lipid Interaction and Functional Consequences; 1 Structure-Function of CD36 and Evidence for its Role in Facilitating Membrane Fatty Acid Transport; 1.1 Introduction; 1.2 Primary Structure; 1.3 Ligand Binding Domains; 1.4 Membrane Localization and Role in Cell Signaling; 1.5 CD36 Gene Structure and Regulation; 1.6 CD36 Deficiency; 1.7 CD36 and Platelet Function; 1.8 CD36 and Atherosclerosis; 1.9 CD36 and Phagocytosis; 1.10 CD36 and Angiogenesis ; 1.11 CD36 and Malaria1.12 CD36 and Fatty Acid Transport; 1.12.1 CD36 is Identified as a Mediator of FA Uptake; 1.12.2 CD36, SHR, and Insulin Resistance; 1.12.3 CD36 Transgenic and Knockout Mice Models; 1.12.4 CD36-null Mice - the Fed Phenotype; 1.12.5 CD36-null Mice - the Fasting Phenotype; 1.12.6 CD36 and Insulin Responsiveness in the Mouse; 1.13 Perspectives and Future Directions; 1.14 References; 2 Role and Function of FATPs in Fatty Acid Uptake; 2.1 Introduction; 2.2 Identification of Fatty Acid Transporter Proteins; 2.3 Structure of FATPs; 2.4 Function of FATPs ; 2.5 Regulation of FATP expression2.6 Significance of FATPs; 2.7 References; 3 Function, Expression, and Regulation of Human ABC Transporters; 3.1 Introduction; 3.2 Structural Features of ATP Binding Cassette (ABC) Transporters; 3.3 Overview of Human ABC Gene Subfamilies; 3.3.1 The ABCA (ABC1) Subfamily; 3.3.2 The ABCB (MDR/TAP) Subfamily; 3.3.3 The ABCC (CFTR/MRP) Subfamily; 3.3.4 The ABCD (ALD) Subfamily; 3.3.5 The ABCE (OABP) and ABCF (GCN20) Subfamilies; 3.3.6 The ABCG (White) Subfamily; 3.4 Diseases and Phenotypes Caused by ABC Transporters; 3.4.1 Familial HDL-deficiency and ABCA1 ; 3.4.2 Retinal Degeneration and ABCA4 (ABCR)3.4.3 Cystic Fibrosis (ABCC7/CFTR); 3.4.4 Multidrug Resistance (ABCB1/MDR1, ABCC1/MRP1, ABCG2); 3.4.5 Adrenoleukodystrophy (ABCD1/ALD); 3.4.6 Sulfonylurea Receptor (ABCC8/SUR); 3.5 Function and Regulation of ABC Transporters in Lipid Transport; 3.5.1 ABCA1 in Macrophage Lipid Transport; 3.5.2 ABCG1 and Other ABCG members in Sterol Homeostasis; 3.5.3 ABC Transporters involved in Hepatobiliary Transport; 3.6 Conclusions and Perspectives; 3.7 References; 4 Albumin Receptors - Structure and Function; 4.1 Introduction ; 4.2 The Search for an Albumin Receptor4.2.1 The Endothelium-Albumin Relationship: Early Concepts; 4.2.2 Identification of Receptors for Native and Modified Albumin in Endothelial Cells; 4.3 Albumin Receptors in the Kidney; 4.3.1 Glomerular Handling of Albumin; 4.3.2 Binding and Uptake of Albumin in the Kidney Proximal Tubule; 4.4 Megalin and Cubilin as Proximal Tubule Albumin Receptors; 4.4.1 Megalin; 4.4.2 Cubilin; 4.5 Albumin as a Signaling Molecule - Implications for Albumin Receptor Function; 4.5.1 LDLR Family as Signaling Receptors; 4.5.2 Megalin as a Signaling Receptor; 4.6 Summary ; 4.7 References
• Sommario/riassunto: In light of the increasing importance of these proteins and their ligands for our understanding of cellular growth, differentiation, and development, as well as of diseases such as obesity, insulin resistance, atherosclerosis, cancer, and inflammation, a team of internationally renowned editors and authors have compiled here the very first comprehensive book on these topics. They describe fatty acid-activated transcription factors as well as membrane and soluble fatty acid transporters, covering such aspects as structure and function, lipid-protein interaction, delivery of ligands, and the rol
• Titolo autorizzato: Cellular proteins and their fatty acids in health and disease
• ISBN: 1-280-52037-X; 9786610520374; 3-527-60528-2; 3-527-60154-6
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9910146243303321
• Lo trovi qui: Univ. Federico II