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Titolo: |
The nature and origin of amyloid fibrils [[electronic resource] /] / [editors, Gregory R. Bock (Organizer) and Jamie A. Goode]
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Pubblicazione: | Chichester ; ; New York, : Wiley, 1996 |
Descrizione fisica: | 1 online resource (268 p.) |
Disciplina: | 612.015782 |
612.8 | |
612.8042 | |
Soggetto topico: | Amyloid |
Amyloid beta-protein | |
Amyloidosis | |
Soggetto genere / forma: | Electronic books. |
Altri autori: |
BockeGregory
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Note generali: | "Symposium on The nature and origin of amyloid fibrils, held at the Palácio dos Marqueses de Pombal, Oeiras, Portugal, 23-25 October 1995"--Contents. |
Nota di bibliografia: | Includes bibliographical references and indexes. |
Nota di contenuto: | THE NATURE AND ORIGIN OF AMYLOID FIBRILS; Contents; Participants; Preface; Introduction; In memoriam; A molecular model of the amyloid fibril; Refined fibril structures: the hydrophobic core in Alzheimer's amyloid b-protein and prion as revealed by X-ray diffraction; General discussion I; Modulating conformational factors in transthyretin amyloid; Proteoglycans and amyloid fibrillogenesis; Molecular mechanisms of fibrillogenesis and the protective role of amyloid P component: two possible avenues for therapy; General discussion II; Metabolism of amyloid proteins |
Alzheimer's disease: genesis of amyloidApolipoprotein E and amyloidogenesis; Interaction of transthyretin with amyloid B-protein: binding and inhibition of amyloid formation; General discussion III; B-amyloid precursor protein and early-o nset Alzheimer's disease; Prion protein amyloid: separation of scrapie infectivity from PrP polymers; General discussion IV; Ageing and amyloid fibrillogenesis: lessons from apolipoprotein Al, transthyretin and islet amyloid polypeptide; General discussion V | |
FAP mutations destabilize transthyretin facilitating conformational changes required for amyloid formationIndex of contributors; Subject index | |
Sommario/riassunto: | Amyloid fibrils are associated with a range of pathological disorders including Alzheimer's Disease, Down's syndrome, diabetes, cardiomyopathies, and transmissible spongiform encephalopathies. This volume is a comprehensive account of recent developments in the understanding of the process of amyloid fibrils. Contains up-to-date data on all of the clinical problems which, despite their pathological significance, are still largely unsolved. |
Titolo autorizzato: | The nature and origin of amyloid fibrils ![]() |
ISBN: | 1-282-34797-7 |
9786612347979 | |
0-470-51492-2 | |
0-470-51493-0 | |
Formato: | Materiale a stampa ![]() |
Livello bibliografico | Monografia |
Lingua di pubblicazione: | Inglese |
Record Nr.: | 9910144740203321 |
Lo trovi qui: | Univ. Federico II |
Opac: | Controlla la disponibilità qui |