03661nam 2200661 a 450 991014474020332120170815162152.01-282-34797-797866123479790-470-51492-20-470-51493-0(CKB)1000000000377216(EBL)470493(OCoLC)609849427(SSID)ssj0000304052(PQKBManifestationID)11275948(PQKBTitleCode)TC0000304052(PQKBWorkID)10278879(PQKB)11530548(MiAaPQ)EBC470493(EXLCZ)99100000000037721619960424d1996 uy 0engur|n|---|||||txtccrThe nature and origin of amyloid fibrils[electronic resource] /[editors, Gregory R. Bock (Organizer) and Jamie A. Goode]Chichester ;New York Wiley19961 online resource (268 p.)Ciba Foundation symposium ;199"Symposium on The nature and origin of amyloid fibrils, held at the Palácio dos Marqueses de Pombal, Oeiras, Portugal, 23-25 October 1995"--Contents.0-471-96361-5 Includes bibliographical references and indexes.THE NATURE AND ORIGIN OF AMYLOID FIBRILS; Contents; Participants; Preface; Introduction; In memoriam; A molecular model of the amyloid fibril; Refined fibril structures: the hydrophobic core in Alzheimer's amyloid b-protein and prion as revealed by X-ray diffraction; General discussion I; Modulating conformational factors in transthyretin amyloid; Proteoglycans and amyloid fibrillogenesis; Molecular mechanisms of fibrillogenesis and the protective role of amyloid P component: two possible avenues for therapy; General discussion II; Metabolism of amyloid proteinsAlzheimer's disease: genesis of amyloidApolipoprotein E and amyloidogenesis; Interaction of transthyretin with amyloid B-protein: binding and inhibition of amyloid formation; General discussion III; B-amyloid precursor protein and early-o nset Alzheimer's disease; Prion protein amyloid: separation of scrapie infectivity from PrP polymers; General discussion IV; Ageing and amyloid fibrillogenesis: lessons from apolipoprotein Al, transthyretin and islet amyloid polypeptide; General discussion VFAP mutations destabilize transthyretin facilitating conformational changes required for amyloid formationIndex of contributors; Subject indexAmyloid fibrils are associated with a range of pathological disorders including Alzheimer's Disease, Down's syndrome, diabetes, cardiomyopathies, and transmissible spongiform encephalopathies. This volume is a comprehensive account of recent developments in the understanding of the process of amyloid fibrils. Contains up-to-date data on all of the clinical problems which, despite their pathological significance, are still largely unsolved.Ciba Foundation symposium ;199.AmyloidCongressesAmyloid beta-proteinCongressesAmyloidosisCongressesElectronic books.AmyloidAmyloid beta-proteinAmyloidosis612.015782612.8612.8042Bocke Gregory906002Goode Jamie283336MiAaPQMiAaPQMiAaPQBOOK9910144740203321The nature and origin of amyloid fibrils2026351UNINA