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Tumour necrosis factor and related cytotoxins [[electronic resource]]



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Titolo: Tumour necrosis factor and related cytotoxins [[electronic resource]] Visualizza cluster
Pubblicazione: Chichester ; ; New York, : Wiley, 1987
Descrizione fisica: 1 online resource (254 p.)
Disciplina: 616.99
616.992071
616.994
Soggetto topico: Tumor necrosis factor
Cytokines
Soggetto genere / forma: Electronic books.
Altri autori: BockGregory  
MarshJoan  
Note generali: Editors: Gregory Bock (Organizer) and Joan Marsh.
Papers presented at the Symposium on Tumour Necrosis Factor and Related Cytotoxins held at the Ciba Foundation, London, 20-22 January 1987.
"A Wiley-Interscience publication."
Nota di bibliografia: Includes bibliographies and indexes.
Nota di contenuto: TUMOUR NECROSIS FACTOR AND RELATED CYTOTOXINS; Contents; Participants; Introduction; Natural production and release of tumour necrosis factor; Possible relationships between in vivo antiturnour activity and toxicity of tumour necrosis factor-a; Human tumour necrosis factors: structure and receptor interactions; Cytocidal activity of tumour necrosis factor: protection by protease inhibitors; Lymphotoxin: cloning, regulation and mechanism of killing; General discussion I; Physiological responses to cachectin; Structure-function relationship of tumour necrosis factor and its mechanism of action
Relationship of tumour necrosis factor and endotoxin to macrophage cytotoxicity, haemorrhagic necrosis and lethal shockAntitumour effects of tumour necrosis factor: cytotoxic or necrotizing activity and its mechanism; Effects of tumour necrosis factor on human tumour xenografts in nude mice; Effects of tumour necrosis factor and related cytokines on vascular endothelial cells; General discussion II; Antiparasitic effects of tumour necrosis factor in vivo and in vitro; Clinical studies with tumour necrosis factor; Summing- up; Index of contributors; Subject index
Sommario/riassunto: The number of factors implicated in the regulation of cell proliferation and differentiation is already considerable and more are continually being identified. This book concentrates on tumor necrosis factor (cachectin) and lymphotoxin, but includes observations of their interactions with other cytokines, especially the interferons and interleukins. TNF can be either cytostatic or cytotoxic to cultured cell lines, and a variety of mechanisms are proposed, ranging from DNA fragmentation to activation of phospholiopases. TNF is also reported to stimulate the growth of normal fibroblasts in vivo.
Titolo autorizzato: Tumour necrosis factor and related cytotoxins  Visualizza cluster
ISBN: 1-282-34589-3
9786612345890
0-470-51352-7
0-470-51353-5
Formato: Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione: Inglese
Record Nr.: 9910144733003321
Lo trovi qui: Univ. Federico II
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Serie: Ciba Foundation symposium ; ; 131.