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Record Nr. |
UNINA9910144733003321 |
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Titolo |
Tumour necrosis factor and related cytotoxins [[electronic resource]] |
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Pubbl/distr/stampa |
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Chichester ; ; New York, : Wiley, 1987 |
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ISBN |
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1-282-34589-3 |
9786612345890 |
0-470-51352-7 |
0-470-51353-5 |
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Descrizione fisica |
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1 online resource (254 p.) |
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Collana |
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Ciba Foundation symposium ; ; 131 |
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Altri autori (Persone) |
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Disciplina |
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616.99 |
616.992071 |
616.994 |
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Soggetti |
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Tumor necrosis factor |
Cytokines |
Electronic books. |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Editors: Gregory Bock (Organizer) and Joan Marsh. |
Papers presented at the Symposium on Tumour Necrosis Factor and Related Cytotoxins held at the Ciba Foundation, London, 20-22 January 1987. |
"A Wiley-Interscience publication." |
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Nota di bibliografia |
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Includes bibliographies and indexes. |
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Nota di contenuto |
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TUMOUR NECROSIS FACTOR AND RELATED CYTOTOXINS; Contents; Participants; Introduction; Natural production and release of tumour necrosis factor; Possible relationships between in vivo antiturnour activity and toxicity of tumour necrosis factor-a; Human tumour necrosis factors: structure and receptor interactions; Cytocidal activity of tumour necrosis factor: protection by protease inhibitors; Lymphotoxin: cloning, regulation and mechanism of killing; General discussion I; Physiological responses to cachectin; Structure-function relationship of tumour necrosis factor and its mechanism of action |
Relationship of tumour necrosis factor and endotoxin to macrophage cytotoxicity, haemorrhagic necrosis and lethal shockAntitumour effects |
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of tumour necrosis factor: cytotoxic or necrotizing activity and its mechanism; Effects of tumour necrosis factor on human tumour xenografts in nude mice; Effects of tumour necrosis factor and related cytokines on vascular endothelial cells; General discussion II; Antiparasitic effects of tumour necrosis factor in vivo and in vitro; Clinical studies with tumour necrosis factor; Summing- up; Index of contributors; Subject index |
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Sommario/riassunto |
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The number of factors implicated in the regulation of cell proliferation and differentiation is already considerable and more are continually being identified. This book concentrates on tumor necrosis factor (cachectin) and lymphotoxin, but includes observations of their interactions with other cytokines, especially the interferons and interleukins. TNF can be either cytostatic or cytotoxic to cultured cell lines, and a variety of mechanisms are proposed, ranging from DNA fragmentation to activation of phospholiopases. TNF is also reported to stimulate the growth of normal fibroblasts in vivo. |
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2. |
Record Nr. |
UNINA9910141363103321 |
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Autore |
Ohlhorst Frank <1964-> |
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Titolo |
Big data analytics [[electronic resource] ] : turning big data into big money / / Frank Ohlhorst |
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Pubbl/distr/stampa |
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Hoboken, N.J., : Wiley, c2013 |
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ISBN |
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1-119-20500-X |
1-283-85145-8 |
1-118-22582-1 |
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Edizione |
[1st edition] |
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Descrizione fisica |
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1 online resource (176 p.) |
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Collana |
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Wiley & SAS business series |
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Disciplina |
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Soggetti |
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Business intelligence |
Data mining |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Nota di contenuto |
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Big Data Analytics: Turning Big Data into Big Money; Copyright; Contents; Preface; Acknowledgments; Chapter 1: What Is Big Data?; The |
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Arrival of Analytics; Where Is the Value?; More to Big Data Than Meets the Eye; Dealing with the Nuances of Big Data; An Open Source Brings Forth Tools; Caution: Obstacles Ahead; Chapter 2: Why Big Data Matters; Big Data Reaches Deep; Obstacles Remain; Data Continue to Evolve; Data and Data Analysis Are Getting More Complex; The Future Is Now; Chapter 3: Big Data and the Business Case; Realizing Value; The Case for Big Data; The Rise of Big Data Options |
Beyond HadoopWith Choice Come Decisions; Chapter 4: Building the Big Data Team; The Data Scientist; The Team Challenge; Different Teams, Different Goals; Don't Forget the Data; Challenges Remain; Teams versus Culture; Gauging Success; Chapter 5: Big Data Sources; Hunting for Data; Setting the Goal; Big Data Sources Growing; Diving Deeper into Big Data Sources; A Wealth of Public Information; Getting Started with Big Data Acquisition; Ongoing Growth, No End in Sight; Chapter 6: The Nuts and Bolts of Big Data; The Storage Dilemma; Building a Platform; Bringing Structure to Unstructured Data |
Processing PowerChoosing among In-house, Outsourced, or Hybrid Approaches; Chapter 7: Security, Compliance, Auditing, and Protection; Pragmatic Steps to Securing Big Data; Classifying Data; Protecting Big Data Analytics; Big Data and Compliance; The Intellectual Property Challenge; Chapter 8: The Evolution of Big Data; Big Data: The Modern Era; Today, Tomorrow, and the Next Day; Changing Algorithms; Chapter 9: Best Practices for Big Data Analytics; Start Small with Big Data; Thinking Big; Avoiding Worst Practices; Baby Steps; The Value of Anomalies; Expediency versus Accuracy |
In-Memory ProcessingChapter 10: Bringing It All Together; The Path to Big Data; The Realities of Thinking Big Data; Hands-on Big Data; The Big Data Pipeline in Depth; Big Data Visualization; Big Data Privacy; Appendix: Supporting Data; ""The MapR Distribution for Apache Hadoop""; ""High Availability: No Single Points of Failure""; About the Author; Index |
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Sommario/riassunto |
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Unique insights to implement big data analytics and reap big returns to your bottom line Focusing on the business and financial value of big data analytics, respected technology journalist Frank J. Ohlhorst shares his insights on the newly emerging field of big data analytics in Big Data Analytics. This breakthrough book demonstrates the importance of analytics, defines the processes, highlights the tangible and intangible values and discusses how you can turn a business liability into actionable material that can be used to redefine markets, improve profits and identify new bu |
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