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Epithelial anion transport in health and disease [[electronic resource] ] : the role of the SLC26 transporters family



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Titolo: Epithelial anion transport in health and disease [[electronic resource] ] : the role of the SLC26 transporters family Visualizza cluster
Pubblicazione: Chichester, U.K., : John Wiley & Sons, 2006
Descrizione fisica: 1 online resource (285 p.)
Disciplina: 571.55364
616.042
Soggetto topico: Epithelial cells
Carrier proteins
Ion channels
Soggetto genere / forma: Electronic books.
Note generali: Description based upon print version of record.
Nota di bibliografia: Includes bibliographical references and index.
Nota di contenuto: Cover; Contents; Chair's introduction; Overview of the SLC26 family and associated diseases; Discussion; Individual characteristics of members of the SLC26 family in vertebrates and their homologues in insects; Discussion; Sulfate transport by SLC26 transporters; Discussion; Sugar transport by members of the SLC26 superfamily; Discussion; SLC26A3 and congenital chloride diarrhoea; Discussion; Expression, regulation and the role of SLC26 C1/HCO exchangers in kidney and gastrointestinal tract; Discussion
Anion exchangers in flux: functional differences between human and mouse SLC26A6 polypeptidesDiscussion; Physiology of electrogenic SLC26 paralogues; Discussion; Role of SLC26-mediated C1/base exchange in proximal tubule NaCl transport; Discussion; SLC26 transporters and the inhibitory control of pancreatic ductal bicarbonate secretion; Discussion; Regulatory interaction between CFTR and the SLC26 transporters; Discussion; Insights from a transgenic mouse model on the role of SLC26A2 in health and disease; Discussion
New insights into the role of pendrin (SLC26A4) in inner ear fluid homeostasisDiscussion; The renal physiology of pendrin (SLC26A4) and its role in hypertension; Discussion; Interaction of prestin (SLC26A5) with monovalent intracellular anions; Discussion; Final discussion; Index of contributors; Subject index
Sommario/riassunto: Cl- absorption and HCO3- secretion are intimately associated processes vital to epithelial function, itself a key physiological activity. Until recently the transporters responsible remained obscure, but a breakthrough occurred with the discovery of the SLC26 transporters family. It is now clear that the SLC26 transporters have broad physiological functions since mutations in several members are linked to a variety of diseases. This book describes the properties of this family in detail, with contributions from the leading global researchers in the field. Complementary views from experts on ot
Titolo autorizzato: Epithelial anion transport in health and disease  Visualizza cluster
ISBN: 1-280-51891-X
9786610518913
0-470-02957-9
0-470-02956-0
Formato: Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione: Inglese
Record Nr.: 9910143720003321
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Serie: Novartis Foundation symposium ; ; 273.