New treatment strategies for dengue and other flaviviral diseases

• Pubblicazione: Chichester, : John Wiley, 2006
• Descrizione fisica: 1 online resource (x, 265 pages) : illustrations, maps
• Disciplina: 616.9185
• Soggetto topico: Dengue; Flaviviruses; Dengue - Treatment; Flaviviruses - Treatment; Dengue - therapy; Flavivirus Infections - therapy
• Soggetto genere / forma: Conference Proceedings.
• Altri autori: BockGregory GoodeJamie
• Note generali: "Novartis Foundation symposium on new treatment strategies for dengue for dengue and other flaviviral diseases, held at the Novartis Institute for Tropical Diseases in Singapore, 26-27 September 2005"--P. v.; "Editors Gregory Bock (Organizer) and Jamie Goode"--P. v.
• Nota di bibliografia: Includes bibliographical references and index.
• Nota di contenuto: Dengue/dengue haemorrhagic fever : history and current status / Duane J. Gubler -- Molecular biology of flaviviruses / Eva Harris, Katherine L. Holden, Dianna Edgil, Charlotta Polacek, Karen Clyde -- Development of novel antivirals against flaviviruses / Chinmay G. Patkar, Richard J. Kuhn -- Entry functions and antigenic structure of flavivirus envelope proteins / Karin Stiasny, Stefan Kiermayr, Franz X. Heinz -- Multiple enzyme activities of flavivirus proteins / R. Padmanabhan, N. Mueller, E. Reichert, C. Yon, T. Teramoto, Y. Kono, R. Takhampunya, S. Ubol, N. Pattabiraman, B. Falgout, V.K. Ganesh, K. Murthy -- Towards the design of flavivirus helicase/NTPase inhibitors : crystallographic and mutagenesis studies of the dengue virus NS3 helicase catalytic domain / Ting Xu, Aruna Sampath, Alex Chao, Daying Wen, Max Nanao, Dahai Luo, Patrick Chene, Subhash G. Vasudevan, Julien Lescar -- Finding new medicines for flaviviral targets / Thomas H. Keller, Yen Liang Chen, John E. Knox, Siew Pheng Lim, Ngai Ling Ma, Sejal J. Patel, Aruna Sampath, Qing Yin Wang, Zheng Yin, Subhash G. Vasudevan -- Structural and functional analysis of dengue virus RNA / Diego E. Alvarez, Maria F. Lodeiro, Claudia V. Filomatori, Silvana Fucito, Juan A. Mondotte, Andrea V. Gamarnik -- Organization of flaviviral replicase proteins in virus-induced membranes : a role for NS1' in japanese encephalitis virus RNA synthesis / Vijaya Satchidanandam, Pradeep Devappa Uchil, Priti Kumar -- CRM1-dependent nuclear export of dengue virus type 2 NS5 / Melinda J. Pryor, Stephen M. Rawlinson, Peter J. Wright, David A. Jans -- T cell responses and dengue haemorrhagic fever / Gavin Screaton, Juthathip Mongkolsapaya -- The evolutionary biology of dengue virus / Edward C. Holmes -- Developing vaccines against flavivirus diseases : past success, present hopes and future challenges / John R. Stephenson -- A genomics approach to understanding host response during dengue infection / Martin L. Hibberd, Ling Ling, Thomas Tolfvenstam, Wayne Mitchell, Chris Wong, Vladimir A. Kuznetsov, Joshy George, Swee-Hoe Ong, Yijun Ruan, Chia L. Wei, Feng Gu, Joshua Fink, Andy Yip, Wei Liu, Mark Schreiber, Subhash G. Vasudevan -- Mouse and hamster models for the study of therapy against flavivirus infections / Nathalie Charlier, Erik De Clercq, Johan Neyts -- Secretion of flaviviral non-structural protein NS1: from diagnosis to pathogenesis / S. Alcon-LePoder, P. Sivard, M.-T. Drouet, A. Talarmin, C. Rice, M. Flamand.
• Sommario/riassunto: This book brings together an international group of experts on dengue and related flaviviruses to examine, critically, current knowledge regarding the dengue virus, the host response and the pathogenesis of dengue haemorrhagic fever and to explore the opportunities to develop new treatments. Issues addressed include the molecular biology of the dengue virus with particular emphasis on its structure and function and on the targeting of virus proteins by potential anti-viral agents. The interaction of the dengue virus with host target cells and the specific receptors on these cells is reviewed. Finally, the book outlines the options for treatment of dengue and dengue haemorrhagic fever, paying particular attention to ways in which vector, host and environment can play a critical role in the spread of this disease. A unique feature of this series is the in-depth discussion sections at the end of each chapter: these record the questions, comments and opinions of the experts in the field concerning all areas of research into dengue viruses and potential treatments.
• Titolo autorizzato: New treatment strategies for dengue and other flaviviral diseases
• ISBN: 9786610653348; 9781280653346; 1280653345; 9780470058008; 0470058005; 9780470058015; 0470058013
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9911019805603321
• Lo trovi qui: Univ. Federico II
• Serie: Novartis Foundation symposium ; ; 277.