LEADER 06256nam 2200793Ia 450 001 9911019805603321 005 20250718214049.0 010 $a9786610653348 010 $a9781280653346 010 $a1280653345 010 $a9780470058008 010 $a0470058005 010 $a9780470058015 010 $a0470058013 035 $a(CKB)1000000000357344 035 $a(EBL)274398 035 $a(SSID)ssj0000210858 035 $a(PQKBManifestationID)11198373 035 $a(PQKBTitleCode)TC0000210858 035 $a(PQKBWorkID)10291589 035 $a(PQKB)10873137 035 $a(MiAaPQ)EBC274398 035 $a(OCoLC)85784913 035 $a(Perlego)2771990 035 $a(EXLCZ)991000000000357344 100 $a20050413d2006 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aNew treatment strategies for dengue and other flaviviral diseases 210 $aChichester $cJohn Wiley$d2006 215 $a1 online resource (x, 265 pages) $cillustrations, maps 225 1 $aNovartis Foundation symposium ;$v277 300 $a"Novartis Foundation symposium on new treatment strategies for dengue for dengue and other flaviviral diseases, held at the Novartis Institute for Tropical Diseases in Singapore, 26-27 September 2005"--P. v. 300 $a"Editors Gregory Bock (Organizer) and Jamie Goode"--P. v. 311 08$aPrint version: New treatment strategies for dengue and other flaviviral diseases. Chichester : J. Wiley, 2006 0470016434 (OCoLC)64554979 311 08$a9780470016435 311 08$a0470016434 320 $aIncludes bibliographical references and index. 327 $aDengue/dengue haemorrhagic fever : history and current status / Duane J. Gubler -- Molecular biology of flaviviruses / Eva Harris, Katherine L. Holden, Dianna Edgil, Charlotta Polacek, Karen Clyde -- Development of novel antivirals against flaviviruses / Chinmay G. Patkar, Richard J. Kuhn -- Entry functions and antigenic structure of flavivirus envelope proteins / Karin Stiasny, Stefan Kiermayr, Franz X. Heinz -- Multiple enzyme activities of flavivirus proteins / R. Padmanabhan, N. Mueller, E. Reichert, C. Yon, T. Teramoto, Y. Kono, R. Takhampunya, S. Ubol, N. Pattabiraman, B. Falgout, V.K. Ganesh, K. Murthy -- Towards the design of flavivirus helicase/NTPase inhibitors : crystallographic and mutagenesis studies of the dengue virus NS3 helicase catalytic domain / Ting Xu, Aruna Sampath, Alex Chao, Daying Wen, Max Nanao, Dahai Luo, Patrick Chene, Subhash G. Vasudevan, Julien Lescar -- Finding new medicines for flaviviral targets / Thomas H. Keller, Yen Liang Chen, John E. Knox, Siew Pheng Lim, Ngai Ling Ma, Sejal J. Patel, Aruna Sampath, Qing Yin Wang, Zheng Yin, Subhash G. Vasudevan -- Structural and functional analysis of dengue virus RNA / Diego E. Alvarez, Maria F. Lodeiro, Claudia V. Filomatori, Silvana Fucito, Juan A. Mondotte, Andrea V. Gamarnik -- Organization of flaviviral replicase proteins in virus-induced membranes : a role for NS1' in japanese encephalitis virus RNA synthesis / Vijaya Satchidanandam, Pradeep Devappa Uchil, Priti Kumar -- CRM1-dependent nuclear export of dengue virus type 2 NS5 / Melinda J. Pryor, Stephen M. Rawlinson, Peter J. Wright, David A. Jans -- T cell responses and dengue haemorrhagic fever / Gavin Screaton, Juthathip Mongkolsapaya -- The evolutionary biology of dengue virus / Edward C. Holmes -- Developing vaccines against flavivirus diseases : past success, present hopes and future challenges / John R. Stephenson -- A genomics approach to understanding host response during dengue infection / Martin L. Hibberd, Ling Ling, Thomas Tolfvenstam, Wayne Mitchell, Chris Wong, Vladimir A. Kuznetsov, Joshy George, Swee-Hoe Ong, Yijun Ruan, Chia L. Wei, Feng Gu, Joshua Fink, Andy Yip, Wei Liu, Mark Schreiber, Subhash G. Vasudevan -- Mouse and hamster models for the study of therapy against flavivirus infections / Nathalie Charlier, Erik De Clercq, Johan Neyts -- Secretion of flaviviral non-structural protein NS1: from diagnosis to pathogenesis / S. Alcon-LePoder, P. Sivard, M.-T. Drouet, A. Talarmin, C. Rice, M. Flamand. 330 $aThis book brings together an international group of experts on dengue and related flaviviruses to examine, critically, current knowledge regarding the dengue virus, the host response and the pathogenesis of dengue haemorrhagic fever and to explore the opportunities to develop new treatments. Issues addressed include the molecular biology of the dengue virus with particular emphasis on its structure and function and on the targeting of virus proteins by potential anti-viral agents. The interaction of the dengue virus with host target cells and the specific receptors on these cells is reviewed. Finally, the book outlines the options for treatment of dengue and dengue haemorrhagic fever, paying particular attention to ways in which vector, host and environment can play a critical role in the spread of this disease. A unique feature of this series is the in-depth discussion sections at the end of each chapter: these record the questions, comments and opinions of the experts in the field concerning all areas of research into dengue viruses and potential treatments. 410 0$aNovartis Foundation symposium ;$v277. 606 $aDengue$vCongresses 606 $aFlaviviruses$vCongresses 606 $aDengue$xTreatment$vCongresses 606 $aFlaviviruses$xTreatment$vCongresses 606 $aDengue$xtherapy 606 $aFlavivirus Infections$xtherapy 608 $aConference Proceedings. 615 0$aDengue 615 0$aFlaviviruses 615 0$aDengue$xTreatment 615 0$aFlaviviruses$xTreatment 615 12$aDengue$xtherapy. 615 22$aFlavivirus Infections$xtherapy. 676 $a616.9185 701 $aBock$b Gregory$0322650 701 $aGoode$b Jamie$0283336 712 02$aNovartis Foundation. 712 02$aNovartis Institute for Tropical Diseases. 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9911019805603321 996 $aNew treatment strategies for dengue and other flaviviral diseases$94421037 997 $aUNINA