Handbook of space pharmaceuticals / / Yashwant V. Pathak, Marlise Araújo dos Santos and Luis Zea, editors

• Pubblicazione: Cham, Switzerland : , : Springer, , [2022]; ©2022
• Descrizione fisica: 1 online resource (1036 pages)
• Disciplina: 616.980214
• Soggetto topico: Space medicine; Pharmaceutical industry; Space flight - Health aspects
• Persona (resp. second.): PathakYashwant; Araújo dos SantosMarlise; ZeaLuis
• Nota di bibliografia: Includes bibliographical references and index.
• Nota di contenuto: Intro -- Foreword -- Preface -- Acknowledgments -- Contents -- About the Editors -- Contributors -- Part I: Principles of Pharmaceuticals -- 1 Introduction to Pharmaceuticals -- Introduction -- Early Days of Drugs and Dosage Forms: The Heritage of Pharmacy -- Period of Scientific Research -- Pharmaceuticals in Modern Perspective -- Pharmaceuticals as Drug Products, Drug Delivery Systems, and Therapeutic Systems -- Brief Introduction to Dosage Forms -- Solid Oral Dosage Forms -- Liquid Dosage Forms: Solutions and Dispersed Systems -- Oral Solutions, Syrups, Elixirs, Spirits, and Tinctures -- Topical Formulations: Semisolid Dosage Forms: Ointments, Creams, Gels, Jellies, Lotions, Pastes, and Foams -- Powders and Granules -- Dosage Forms and Drug Delivery for Specific Routes of Administration -- Novel Drug Delivery Systems and Devices -- Challenges in Using Pharmaceuticals in Space -- Drugs Used During the Spaceflights for the Astronauts -- An Overview -- Impact of Spaceflight on the Human Body -- Pharmacokinetic and Pharmacodynamic Changes -- Conclusion -- References -- 2 Understanding the Routes of Administration -- Oral Route of Administration -- Pathophysiology of Epithelial Barrier -- Buccal Cavity -- Stomach -- Small Intestine -- Large Intestine -- Physicochemical Properties of Drugs -- Dissolution and Solubility -- Lipophilicity-Permeability -- Other Factors -- Absorption Mechanism -- Applications and Examples -- Parenteral Route of Administration -- Intravenous (IV) Injection -- Intramuscular (IM) Injection -- Subcutaneous (SC) Injection -- Intradermal (ID) Injection -- Topical and Transdermal Administration -- Ophthalmic Administration -- Buccal and Sublingual -- Rectal and Vaginal -- Inhalational -- Conclusion -- References -- 3 Physicochemical Basic Principles for Solid Dosage Forms -- Introduction. ; Polymorphism in Solid Dosage Forms: Crystalline and Amorphous States -- Size Matters: Particle Size Properties -- Morphological Evaluation of Solid Dosage Forms: A Nanoperspective -- Solid-State Stability of the Component Actives and Excipients -- Hygroscopicity and Hydroactivity -- Solubility Aspects -- Dissolution Properties -- Future Developments in the Design of Solid Dosage Forms -- References -- 4 Physicochemical Basic Principles for Liquid Dosage Forms -- Terms Used -- Liquid Formulations -- Liquids for Internal Use -- Syrups -- Elixirs -- Drops -- Intravenous Solutions/Fluids -- Liquids for External Use -- Liniment or Balm -- Lotion -- Tincture -- Physiochemical Properties of Active Pharmaceutical Ingredient (API) in LDFS -- Solubility -- Factors Affecting Solubility of API -- pKa/Dissociation Constants -- Partition Coefficient -- Effects of Physicochemical Properties on Manufacturing Processes -- Future Directions and Conclusion -- References -- 5 Solid Dosage Forms: Formulation and Characterization -- Introduction and Need of Solid Dosage Forms for Space Pharmaceuticals -- The Physiological Changes in the Space and Available Solid Dosage Form as Space Pharmaceuticals -- Formulation of Space Pharmaceuticals -- Challenges for a Solid Dosage in Context of Stability in Space -- Stability, Formulation, and Characterization Challenges -- Comparison of Solid Dosage Forms with Other Dosage Forms for Space Pharmaceuticals -- Solid Dosage Form Design for Space (Gibson 2009) -- Future of the Medical Treatment and the Pharmaceuticals in Space -- References -- 6 Pharmaceutical Liquid Dosage Forms in Space: Looking Toward the Future by Learning from the Past -- Introduction -- Pharmaceutical Formulations in Space Missions -- The Types of Pharmaceutical Formulations: Solid, Semisolid, and Liquid Dosage Forms. ; General Properties of Pharmaceutical Formulations -- Liquid Dosage Formulations -- Pharmaceutical Liquid Dosage Forms: Solutions, Suspensions, Colloids, and Emulsions -- Pharmaceutical Solutions -- Types of Pharmaceutical Solutions -- Physical and Chemical Characteristics of Pharmaceutical Solutions -- The Medical Use of Pharmaceutical Solutions -- The Effect of Space on the Stability of Solutions -- Mechanism of Space-Based Degradation of Pharmaceutical Solutions -- Pharmaceutical Suspensions -- Types of Pharmaceutical Suspensions -- Physical and Chemical Characteristics of Pharmaceutical Suspensions -- The Medical Use of Pharmaceutical Suspensions -- The Effect of Space on the Stability of Suspensions -- Liquid Dosage Forms and Space Travel: Overall Considerations -- Fluids and Microgravity Influence on Physical Systems -- Pharmaceutical Product Stability and Shelf Life -- Physical Factors Affecting Phenomena Associated with Pharmaceutical Solutions and Suspensions -- Conclusion -- References -- 7 Nano Drug Delivery Systems for Space Applications -- Biopharmaceutical Challenges of Therapeutics in Space -- Necessity for Nanoparticle-Based Drug Formulations -- Nanotechnology Approach for Space Medicine -- Innovative Means for Drug Delivery -- Constant Drug Delivery Nanotechnologies for Space Exploration -- Applications of Nano-Gland for Space Medicine -- Bionano Scaffolds (BNS) as a Space Nanomedicine -- Nanomedical Devices for Loss of Bone Density and Mass Under Microgravity -- Carbon Nanotubes for Cardiac Function and Muscle Atrophy -- Dendrimeric Nanodevice for Detection of Cellular Damage in Astronauts -- Targeted Nanoparticles to Alleviate Microgravity-Induced Ocular Anomalies -- Polymeric Nanofiber Scaffolds to Prevent or Counteract the Deleterious Effects of Microgravity on the Brain and DNA -- Quantum Dots for Diagnostic Testing. ; Grapheme-Based Nanocomposites -- Gold Nanoparticles for Biomedical Application -- Conclusion -- References -- 8 Basic Principles of Biopharmaceutics and Pharmacokinetics During Spaceflight -- Introduction -- Basic Principles of Pharmacokinetics -- Clearance -- Volume of Distribution -- Half-Life -- Bioavailability -- Absorption -- Factors Affecting Absorption -- Dissolution Rate -- Gastric Emptying and Intestinal Transit -- Presystemic Metabolism -- Studies of Spaceflight Impact on Absorption -- Inflight Studies of Drug Absorption -- Simulated Microgravity Studies of Drug Absorption -- Distribution -- Factors Affecting Distribution -- Fluid Shift -- Protein Binding in the Blood -- Protein Binding in Tissue -- Studies of Spaceflight Impact on Distribution -- Simulated Microgravity Studies of Drug Distribution -- Metabolism and Excretion -- Factors Affecting Metabolism and Excretion -- Intrinsic Clearance -- Protein Binding -- Blood Flow -- Other Routes of Elimination -- Studies of Spaceflight Impact on Metabolism and Excretion -- Inflight Studies of Drug Metabolism and Excretion -- Simulated Microgravity Studies of Drug Metabolism and Excretion: Bed Rest -- Simulated Microgravity Studies of Drug Metabolism and Excretion: Tail-Suspended Rat Model -- Conclusion -- References -- 9 Medications in Microgravity: History, Facts, and Future Trends -- Where Did We Begin? -- Evolution of the Medical Kit -- The Medical Kit -- Medical Incidents and Frequency -- Dose Response -- Routes of Administration -- Multiple Causes -- Future Recommendations -- Ground Research Models -- References -- 10 Evaluation of Physical and Chemical Changes in Pharmaceuticals Flown on Space Missions -- Causes of Physical and Chemical Changes -- Radiation Effects -- Cumulative Radiation Dose -- Low-Earth Orbits -- High-Earth Orbits and Beyond -- Physical Changes Due to Radiation. ; Thermal Considerations -- Magnetic and Electric Field Effects -- Effects of Acceleration -- Effects on Storage Containers -- Effects on the Medication -- Effects of Vibration -- Effects of Freefall -- Atmospheric Conditions -- Decomposition and Degradation -- Packaging and Coating -- Container Degradation -- Glass -- Polymers -- Realized Changes from Experimentation -- Space Transportation System (Du et al. 2011) -- Methodology -- Analysis -- Results -- Physical Changes -- Chemical Changes -- The Effects of Environmental Factors -- Characteristics of Longevity -- International Space Station (Wotring 2016) -- Specific Drug Susceptibility -- Manufacturing Pharmaceuticals for Space -- References -- 11 Implications of Microgravity on Microemulsions and Nanoemulsions -- Microemulsions, Nanoemulsions, and Types of Formulations -- Some Considerations of Microemulsions or Nanoemulsions and Pharmacokinetics in Microgravity -- What Can Be Expected -- Future Considerations -- References -- 12 Three-Dimensional Printing (3DP) for Space Pharmaceuticals -- Introduction -- 3DP Techniques and Potential Opportunities in Space Pharmaceuticals -- Material Jetting - Inkjet Printing -- Binder Jetting 3DP -- Powder Bed Fusion: Selective Laser Sintering 3DP -- VAT Photopolymerization -- Material Extrusion: Fused Deposition Modeling 3DP -- Material Extrusion: Semi-Solid Extrusion 3DP -- Applications of 3DP for Space Pharmaceuticals -- Multifaceted Applications of 3DP in Drug Delivery Research -- Personalized Drug Dosing -- Complex Drug Release Profile -- Customized Topical Treatment Devices -- Drug Delivery Devices with Unique Dosage Forms -- Fabrication of Polypills Using 3DP Technology -- On-Demand Manufacturing -- Effects of Microgravity on Human Body and Space Pharmaceuticals -- Cardio-Circulatory: Fluid Shifts -- Muscle and Bone Loss -- Effects on the Immune System. ; Alterations in the Gastrointestinal System.
• Titolo autorizzato: Handbook of Space Pharmaceuticals
• ISBN: 3-030-05526-4
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9910559394703321
• Lo trovi qui: Univ. Federico II