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Autore: | Silvia Gregori |
Titolo: | HLA-G-mediated Immune Tolerance: Past and New Outlooks |
Pubblicazione: | Frontiers Media SA, 2017 |
Descrizione fisica: | 1 electronic resource (92 p.) |
Soggetto non controllato: | Pregnancy |
Autoimmunity | |
Immuno-modulation | |
Pre-Eclampsia | |
Infections | |
Exosomes | |
HLA-G | |
polymorphisms | |
tolerance | |
Cancer | |
Persona (resp. second.): | Joel LeMaoult |
Sommario/riassunto: | The non-classical HLA class I molecule HLA-G is different from classical HLA class I molecules because of the low polymorphism in the coding region, the fact that HLA-G primary transcript is alternatively spliced in seven isoforms, and the inhibitory action on immune cells. Although HLA-G is low polymorphic, variants in both promoter and 3’ un-translated region (UTR) of HLA-G locus regulate its expression. In healthy conditions, a basal level of HLA-G gene transcription is observed in most cells and tissues; however, translation into HLA-G protein is restricted to trophoblasts in the placenta, where it participates in promoting tolerance at the fetal-maternal interface. HLA-G is also expressed by thymic epitelial, cornea, mesenchymal stem cells, nail matrix, pancreatic beta cells, erythroid, and endothelial precursors. HLA-G can be neo-expressed in adult tissues in pathological conditions, and its expression has been documented autoimmune disorders, viral infections, and cancer. In the latter setting de novo HLA-G expression is associated with the capability of tumor cells to evade the immune control. In the last decade it has become evident that HLA-G expression on T cells and antigenpresenting cells confers to these cells tolerogenic properties. This Research Topic focused on i) summarizing updated clinical and immunological evidences that HLA-G expression is associate with beneficial or detrimental tolerance, ii) gathering new insights into the mechanisms governing the expression of HLA-G in healthy and pathological conditions, such as pre-eclampsia, and iii) examining the mechanisms underlying HLA-G mediated tolerance. |
Altri titoli varianti: | HLA-G-mediated Immune Tolerance |
Titolo autorizzato: | HLA-G-mediated Immune Tolerance: Past and New Outlooks |
Formato: | Materiale a stampa |
Livello bibliografico | Monografia |
Lingua di pubblicazione: | Inglese |
Record Nr.: | 9910220053103321 |
Lo trovi qui: | Univ. Federico II |
Opac: | Controlla la disponibilità qui |