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[null,"1.","Record Nr.",null,"UNINA9910495966503321"]
[null,null,"Autore",null,"Valensi Lucette"]
[null,null,"Titolo",null,"Jewish memories / / Lucette Valensi and Nathan Wachtel ; translated from the French by Barbara Harshav [[electronic resource]]"]
[null,null,"Pubbl/distr/stampa",null,"Berkeley, : University of California Press, c1991"]
[null,null,"ISBN",null,"0-585-28107-6"]
[null,null,"Descrizione fisica",null,"1 online resource (v, 351 p. )"]
[null,null,"Disciplina",null,"909/.04924082/0922"]
[{"$nulls":4},"B"]
[null,null,"Soggetti",null,"Jews - France"]
[{"$nulls":4},"Holocaust, Jewish (1939-1945) - France - Personal narratives"]
[{"$nulls":4},"Immigrants - France"]
[{"$nulls":4},"Oral history"]
[{"$nulls":4},"Middle East"]
[{"$nulls":4},"Regions & Countries - Asia & the Middle East"]
[{"$nulls":4},"History & Archaeology"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Translation of: Mémoires juives."]
[null,null,null,"Nota di bibliografia","Includes bibliographical references."]
[null,null,"Nota di contenuto",null,"Translation of: Mémoires juives."]
[null,"2.","Record Nr.",null,"UNINA9910220053103321"]
[null,null,"Autore",null,"Silvia Gregori"]
[null,null,"Titolo",null,"HLA-G-mediated Immune Tolerance: Past and New Outlooks"]
[null,null,"Pubbl/distr/stampa",null,"Frontiers Media SA, 2017"]
[null,null,"Descrizione fisica",null,"1 online resource (92 p.)"]
[null,null,"Collana",null,"Frontiers Research Topics"]
[null,null,"Soggetti",null,"Medicine"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Sommario/riassunto","The non-classical HLA class I molecule HLA-G is different from classical HLA class I molecules because of the low polymorphism in the coding region, the fact that HLA-G primary transcript is alternatively spliced in seven isoforms, and the inhibitory action on immune cells. Although HLA-G is low polymorphic, variants in both promoter and 3' un-translated region (UTR) of HLA-G locus regulate its expression. In healthy conditions, a basal level of HLA-G gene transcription is observed in most cells and tissues; however, translation into HLA-G protein is restricted to trophoblasts in the placenta, where it participates in promoting tolerance at the fetal-maternal interface. HLA-G is also expressed by thymic epitelial, cornea, mesenchymal stem cells, nail matrix, pancreatic beta cells, erythroid, and endothelial precursors. HLA-G can be neo-expressed in adult tissues in pathological conditions, and its expression has been documented autoimmune disorders, viral infections, and cancer. In the latter setting de novo HLA-G expression is associated with the capability of tumor cells to evade the immune control. In the last decade it has become evident that HLA-G expression on T cells and antigenpresenting cells confers to these cells tolerogenic properties. This Research Topic focused on i) summarizing updated clinical and immunological evidences that HLA-G expression is associate with beneficial or detrimental tolerance, ii) gathering new insights into the mechanisms governing the expression of HLA-G in healthy and pathological conditions, such as pre-eclampsia, and iii) examining the mechanisms underlying HLA-G mediated tolerance."]