The Major Histocompatibility Complex (MHC/ HLA) in Medicine : A Personal Recollection

• Autore: Garrido Federico
• Pubblicazione: Cham : , : Springer International Publishing AG, , 2024; ©2024
• Edizione: 1st ed.
• Descrizione fisica: 1 online resource (116 pages)
• Nota di contenuto: Intro -- Acknowledgments -- About This Book -- Contents -- About the Author -- 1: The Discovery of the Major Histocompatibility Complex (MHC): The H-2 in Mice and the HLA in Man -- 1.1 The H-2 System -- 1.2 The HLA System -- 1.2.1 The HLA International Workshops -- References -- 2: The Discovery of the Biological Function of the MHC -- 2.1 T Lymphocyte Killing Restricted by MHC -- 2.2 The Discovery of Natural Killer Cells -- References -- 3: HLA Genes and Molecules -- 3.1 Genomic Organization of the HLA System -- 3.2 Molecular Structure of HLA Class-I and Class-II -- 3.2.1 HLA Class-I -- 3.2.2 HLA Class-II -- 3.3 Cellular and Tissue Expression of HLA Molecules -- 3.4 Antigen Processing and Presentation to T Lymphocytes -- 3.4.1 Antigen Presentation to CD8+ T Lymphocytes -- 3.4.2 Antigen Presentation to CD4+ T Lymphocytes -- 3.5 The Different Recognition of HLA Class-I Molecules by Cytotoxic CD8+ T Lymphocytes and NK Cells -- References -- 4: HLA in Transplantation -- 4.1 HLA in Kidney Transplantation -- 4.2 HLA in Bone Marrow Transplantation -- 4.3 The Human Leucocyte Differentiation Antigens (HLDA) Workshops: Their Impact in Transplantation -- References -- 5: MHC/HLA Class-I Loss and Cancer Immune Escape -- 5.1 The Discovery of Tumour Antigens Recognized by T Lymphocytes -- 5.2 The Discovery of MHC Class-I Loss in Tumours -- 5.2.1 Altered HLA Class-I Tumour Phenotypes -- 5.2.2 The Transition From HLA Class-I Positive to HLA Class-I Negative Tumours During Cancer Progression -- 5.2.3 HLA Class-I Expression in Metastatic Nodes -- 5.2.4 HLA Class-I Losses and Cancer Immunotherapy -- References -- 6: HLA and Disease Association -- 6.1 Diseases Associated with HLA Class-I and Class-II -- 6.1.1 Ankylosing Spondylitis (AS) -- 6.1.2 Celiac Disease -- 6.1.3 Insulin-Dependent Type-1 Diabetes (IDD) -- 6.1.4 Narcolepsy. ; 6.1.5 Rheumatoid Arthritis -- 6.2 Conclusion -- References -- 7: HLA in Population Genetics -- 7.1 HLA and Human Migrations -- 7.2 Generation of HLA Diversity and Selection of HLA Alleles by Pathogens -- References -- Concluding Remarks.
• Titolo autorizzato: The Major Histocompatibility Complex (MHC
• ISBN: 9783031598661
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9910874660703321
• Lo trovi qui: Univ. Federico II