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024 7 $a10.1007/978-3-031-59866-1
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035   $a(DE-He213)978-3-031-59866-1
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101 0 $aeng
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181   $ctxt$2rdacontent
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200 14$aThe Major Histocompatibility Complex (MHC/ HLA) in Medicine $eA Personal Recollection /$fby Federico Garrido
205   $a1st ed. 2024.
210  1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2024.
215   $a1 online resource (116 pages)
311 08$a9783031598654 
320   $aIncludes bibliographical references.
327   $aChapter 1: The discovery of the Major Histocompatibility Complex (MHC): The H-2 in mice and the HLA in humans -- Chapter 2: The discovery of the biological function of the MHC -- Chapter 3: HLA genes and molecules -- Chapter 4: HLA in transplantation -- Chapter 5: HLA class-I loss and cancer Immune escape -- Chapter 6: HLA and disease association -- Chapter 7: HLA in population genetics.
330   $aThis book takes the reader on a journey through past and current research on the Major Histocompatibility Complex (MHC/HLA). It describes how it was discovered, what its biological function is and its application in medicine. The reader will learn about the molecular structure of the encoded molecules and different aspects of their role in medicine, including organ transplantation, their link to autoimmune diseases, cancer immunity, resistance to infectious diseases, and other related scientific areas, such as population genetics. In particular, the book focusses on the impact of MHC/HLA altered expression in tumours and their relevance in cancer immune escape and immunotherapy. It contains a large number of original figures and photographs of pioneers in the field, who made seminal contributions. Each chapter is supported by relevant key publications and enriched with a personal account of the early research that has contributed to our current understanding of the role of the major histocompatibility complex. This book is an excellent resource for all scientists in the biomedical life sciences who wish to gain insight into the discovery of the MHC/HLA and the role of this important genetic complex in health and disease.
606   $aImmunology
606   $aCancer
606   $aGenetics
606   $aCancer$xGenetic aspects
606   $aImmunology
606   $aCancer Biology
606   $aGenetics and Genomics
606   $aCancer Genetics and Genomics
615  0$aImmunology.
615  0$aCancer.
615  0$aGenetics.
615  0$aCancer$xGenetic aspects.
615 14$aImmunology.
615 24$aCancer Biology.
615 24$aGenetics and Genomics.
615 24$aCancer Genetics and Genomics.
676   $a616.079
700   $aGarrido$b Federico$0995416
801  0$bMiAaPQ
801  1$bMiAaPQ
801  2$bMiAaPQ
912   $a9910874660703321
996   $aThe Major Histocompatibility Complex (MHC$94183988
997   $aUNINA