Drug discovery and design : medical aspects / / edited by J. Matsoukas and T. Mavromoustakos

• Pubblicazione: Amsterdam ; ; Washington, D.C., : IOS Press; Tokyo, : Ohmsha, c2002
• Edizione: 1st ed.
• Descrizione fisica: 1 online resource (335 p.)
• Disciplina: 615/.19
• Soggetto topico: Drugs - Research; Drugs - Testing; Pharmaceutical technology
• Altri autori: MatsoukasJ (John) MavromoustakosT (Thomas)
• Note generali: "This volume is a potpourri of review articles and research articles related to the 'Bioactive Drugs in Drug Discovery and Design'. It can be regarded as a continuation of Volume 22 published by IOS Press in the series Biomedical and Health Research."--P. v.
• Nota di bibliografia: Includes bibliographical references and index.
• Nota di contenuto: Cover; Title page; Preface; Contents; Design, Synthesis and Biological Evaluation of Cyclic Angiotensin II Analogues with 3,5 Side-Chain Bridges: Role of C-Terminal Aromatic Residue and Positions 3,5 for Activity; Synthesis of RGD Analogs Incorporating Moiety of Salicylic Acid Derivatives and their Effect on Human Platelet Aggregation In Vitro; Synthesis of Substance P C-terminal Analogs Incorporating D-Amino Acids and Studies of their Antineoplastic Properties in Vitro ; Synthesis of Chiral Tetramic Acids Using Activated Derivatives of N-protected α-Amino Acids as Precursors. Structural Characterization of Tetramic Acid Complexes With Metal IonsL-Asparaginase: Structure, Properties and Anti-Tumor Activity; Growth Inhibitory and Apoptotic Effects of Gonadotropin-Releasing Hormone (GnRH) on Human Hepatocellular Carcinoma; Recent Applications of the Amide Approach to the Synthesis of Medicinally Interesting Polyamine Analogues; Design and Synthesis of Fluorescent Steroidal Lipopolyamine Conjugates for Monitoring Gene Delivery ; Synthesis of (S)-2-Amino-oleic Acid and Other Bioactive Molecules through Glutamate SemialdehydesDevelopment of New Methods for Fluorometric Assays of Enzymes; Enhancement of the Cytogenetic and Cytostatic Activity of Chlorambucil after its Esteric Connection with a Hecogenin Lactam; In Searching for New Anti-Influenza A Drugs: Heterocyclic and Carbocyclic Aminoadamantanes Bearing a 2-Adamantyl Group with Potent Activity Against Influenza A Virus; Design, Synthesis and Conformational Properties of Linear Analogues of Human Myelin Basic Protein Epitope MBP[sub(1-11)] ; The Effects of Vinblastine Sulfate on Dipalmitoylphosphatidylcholine Single and Multiple Bilayer MembranesStealth Liposomal Vinca Alkaloids (Vinorelbine and Vincrastine) and In Vitro Studies on Release by Buffer and Rat Plasma; Structural Elucidation, Conformational Properties and Effects in Membrane Bilayers of the Toxin Paralysin, β-Ala-Tyr from Larvae of the Gray Flesh Fly; Effects of NSAIDs in Membrane Bilayers; The Structure of Endotoxin-Neutralizing Peptides Bound to LPS ; Synthesis and Conformational Analysis of Steroidal Carriers of Alkylating Agents with the Use of Two-Dimensional Nuclear Magnetic ResonanceStructure Elucidation and Conformational Properties of Irbesartan; [sup(1)]H and [sup(13)]C NMR Assignment and Conformational Studies of a Myelin Basic Protein Epitope 74-85 Implicated in Multiple Sclerosis; Conformational Analysis of Biomolecules in Solution: NMR - 3D Structures - Biological Implications; Synthesis and Structural Investigation of a Synthetic LHRH Analogue in Solution ; Synthesis, Biological Evaluation & NMR Solution Structural Models of New Oxytocin Analogues
• Sommario/riassunto: This work covers review articles and research articles related to the ""Bioactive Drugs in Drug Discovery Design"". It covers the synthesis and properties of bioactive molecules and enzymes, the role of membranes in drug activity and formulation.
• Titolo autorizzato: Drug discovery and design
• ISBN: 1-280-50553-2; 9786610505531; 600-00-0403-6; 1-60129-420-4
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9910821903703321
• Lo trovi qui: Univ. Federico II
• Serie: Biomedical and health research ; ; v. 55.