LEADER 05242nam 22007334a 450 001 9910821903703321 005 20200520144314.0 010 $a1-280-50553-2 010 $a9786610505531 010 $a600-00-0403-6 010 $a1-60129-420-4 035 $a(CKB)111087028238646 035 $a(EBL)267490 035 $a(OCoLC)559968642 035 $a(SSID)ssj0000141548 035 $a(PQKBManifestationID)11136930 035 $a(PQKBTitleCode)TC0000141548 035 $a(PQKBWorkID)10090171 035 $a(PQKB)10261077 035 $a(MiAaPQ)EBC267490 035 $a(Au-PeEL)EBL267490 035 $a(CaPaEBR)ebr10116490 035 $a(CaONFJC)MIL50553 035 $a(OCoLC)53020582 035 $a(EXLCZ)99111087028238646 100 $a20020515d2002 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aDrug discovery and design $emedical aspects /$fedited by J. Matsoukas and T. Mavromoustakos 205 $a1st ed. 210 $aAmsterdam ;$aWashington, D.C. $cIOS Press ;$aTokyo $cOhmsha$dc2002 215 $a1 online resource (335 p.) 225 1 $aBiomedical and health research ;$vv. 55 300 $a"This volume is a potpourri of review articles and research articles related to the 'Bioactive Drugs in Drug Discovery and Design'. It can be regarded as a continuation of Volume 22 published by IOS Press in the series Biomedical and Health Research."--P. v. 311 $a0-585-45891-X 311 $a1-58603-261-5 320 $aIncludes bibliographical references and index. 327 $aCover; Title page; Preface; Contents; Design, Synthesis and Biological Evaluation of Cyclic Angiotensin II Analogues with 3,5 Side-Chain Bridges: Role of C-Terminal Aromatic Residue and Positions 3,5 for Activity; Synthesis of RGD Analogs Incorporating Moiety of Salicylic Acid Derivatives and their Effect on Human Platelet Aggregation In Vitro; Synthesis of Substance P C-terminal Analogs Incorporating D-Amino Acids and Studies of their Antineoplastic Properties in Vitro 327 $aSynthesis of Chiral Tetramic Acids Using Activated Derivatives of N-protected ?-Amino Acids as Precursors. Structural Characterization of Tetramic Acid Complexes With Metal IonsL-Asparaginase: Structure, Properties and Anti-Tumor Activity; Growth Inhibitory and Apoptotic Effects of Gonadotropin-Releasing Hormone (GnRH) on Human Hepatocellular Carcinoma; Recent Applications of the Amide Approach to the Synthesis of Medicinally Interesting Polyamine Analogues; Design and Synthesis of Fluorescent Steroidal Lipopolyamine Conjugates for Monitoring Gene Delivery 327 $aSynthesis of (S)-2-Amino-oleic Acid and Other Bioactive Molecules through Glutamate SemialdehydesDevelopment of New Methods for Fluorometric Assays of Enzymes; Enhancement of the Cytogenetic and Cytostatic Activity of Chlorambucil after its Esteric Connection with a Hecogenin Lactam; In Searching for New Anti-Influenza A Drugs: Heterocyclic and Carbocyclic Aminoadamantanes Bearing a 2-Adamantyl Group with Potent Activity Against Influenza A Virus; Design, Synthesis and Conformational Properties of Linear Analogues of Human Myelin Basic Protein Epitope MBP[sub(1-11)] 327 $aThe Effects of Vinblastine Sulfate on Dipalmitoylphosphatidylcholine Single and Multiple Bilayer MembranesStealth Liposomal Vinca Alkaloids (Vinorelbine and Vincrastine) and In Vitro Studies on Release by Buffer and Rat Plasma; Structural Elucidation, Conformational Properties and Effects in Membrane Bilayers of the Toxin Paralysin, ?-Ala-Tyr from Larvae of the Gray Flesh Fly; Effects of NSAIDs in Membrane Bilayers; The Structure of Endotoxin-Neutralizing Peptides Bound to LPS 327 $aSynthesis and Conformational Analysis of Steroidal Carriers of Alkylating Agents with the Use of Two-Dimensional Nuclear Magnetic ResonanceStructure Elucidation and Conformational Properties of Irbesartan; [sup(1)]H and [sup(13)]C NMR Assignment and Conformational Studies of a Myelin Basic Protein Epitope 74-85 Implicated in Multiple Sclerosis; Conformational Analysis of Biomolecules in Solution: NMR - 3D Structures - Biological Implications; Synthesis and Structural Investigation of a Synthetic LHRH Analogue in Solution 327 $aSynthesis, Biological Evaluation & NMR Solution Structural Models of New Oxytocin Analogues 330 $aThis work covers review articles and research articles related to the ""Bioactive Drugs in Drug Discovery Design"". It covers the synthesis and properties of bioactive molecules and enzymes, the role of membranes in drug activity and formulation. 410 0$aBiomedical and health research ;$vv. 55. 606 $aDrugs$xResearch 606 $aDrugs$xTesting 606 $aPharmaceutical technology 615 0$aDrugs$xResearch. 615 0$aDrugs$xTesting. 615 0$aPharmaceutical technology. 676 $a615/.19 701 $aMatsoukas$b J$g(John)$01309053 701 $aMavromoustakos$b T$g(Thomas)$01646083 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910821903703321 996 $aDrug discovery and design$93992915 997 $aUNINA