TRP channels as therapeutic targets : from basic science to clinical use / / edited by Arpad Szallasi ; contributors, M. Allen McAlexander [and fifty-nine others]

• Pubblicazione: Amsterdam, [Netherlands] : , : Academic Press, , 2015; ©2015
• Descrizione fisica: 1 online resource (530 p.)
• Disciplina: 572.696
• Soggetto topico: TRP channels
• Persona (resp. second.): SzallasiArpad <1958->; McAlexanderM. Allen
• Note generali: Description based upon print version of record.
• Nota di bibliografia: Includes bibliographical references at the end of each chapters and index.
• Nota di contenuto: Front Cover; TRP Channels as Therapeutic Targets: From Basic Science to Clinical Use; Copyright; Contents; Contributors; Preface; Chapter 1: An Introduction to Transient Receptor Potential Ion Channels and Their Roles in Disease; Discovery and General Properties of TRP Channels; TRP Channels in Normal Physiology; TRP Channels and Sensory Physiology; TRP Channels and Cardiovascular Function; TRP Channels and Gastrointestinal Function; TRP Channels and Urological Function; TRP Channels and the Brain; TRP Channels and Immune Function; TRP Channels and Development; TRP Channels and Disease ; Therapeutic Strategies Based on TRP Channel ModulationAcknowledgment; References; Chapter 2: Transient Receptor Potential Dysfunctions in Hereditary Diseases: TRP Channelopathies and Beyond; Introduction; TRPC Channelopathies; TRPV Channelopathies; TRPM Channelopathies; TRPA Channelopathies; TRPML Channelopathies; TRPP Channelopathies; Conclusions; Acknowledgments; References; Chapter 3: The Role of TRPV1 in Acquired Diseases: Therapeutic Potential of TRPV1 Modulators; Introduction; TRPV1 and Pain; TRPV1 and Gastrointestinal System-Related Disease; TRPV1 and Urinary System-Related Diseases ; TRPV1 and Central Nervous System-Related DiseasesTRPV1 and Respiratory System-Related Diseases; TRPV1 and Cancer; TRPV1 and Cardiovascular System-Related Diseases; TRPV1 and Metabolic Diseases; TRPV1 and Other Disease Conditions; Conclusions; Acknowledgment; References; Chapter 4: TRP Gene Polymorphism and Disease Risk; TRP Gene Polymorphism; TRPA1 ; The TRPC Subfamily; The TRPM Subfamily; The TRPML Subfamily; The TRPV Subfamily; Disease Risk, Clinical Diagnosis, and Personalized Medicine; References; Chapter 5: Use of Topical Capsaicin for Pain Relief; Introduction; Pharmacodynamics ; PharmacokineticsEfficacy and Therapeutic Uses; Postherpetic Neuralgia; HIV -Associated Distal Sensory Polyneuropathy; Other Neuropathic Pain States; Safety and Tolerability; Delivery of Treatment with Capsaicin 8% Patch-Practical Aspects; Application Procedure for the Capsaicin 8% Patch; Postprocedural Instructions for Patients; References; Chapter 6: TRPV1 Agonist Cytotoxicity for Chronic Pain Relief: From Mechanistic Understanding to Clinical Application; Introduction; Mechanisms of TRPV1 Agonist Therapeutic Action; Four Main Determinants of TRPV1 Agonist Actions ; Selectivity of RTX at the Cellular LevelRTX Produces a Prolonged Channel Open Time; TRPV1 Is Selectively Expressed in Subpopulations of DRG Neurons; RTX Is Administered Locally; Companion Dog and Human Studies; Companion (Pet) Dog Models of Chronic Pain; TRPV1 Agonists in the Companion Dog Model of Bone Cancer; TRPV1 Agonists in the Companion Dog Model of Osteoarthritis; Human Studies; References; Chapter 7: Intravesical Capsaicin and Resiniferatoxin for Bladder Disorders; Capsaicin and Resiniferatoxin Targets and Effects in the Urinary Bladder ; The Rationale for Using Vanilloids to Overcome Lower Urinary Tract Symptoms
• Titolo autorizzato: TRP channels as therapeutic targets
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9910788295403321
• Lo trovi qui: Univ. Federico II