LEADER 04694nam 2200589 450 001 9910788295403321 005 20230120012959.0 035 $a(CKB)2670000000608824 035 $a(EBL)2011125 035 $a(SSID)ssj0001541554 035 $a(PQKBManifestationID)11875050 035 $a(PQKBTitleCode)TC0001541554 035 $a(PQKBWorkID)11534979 035 $a(PQKB)11429348 035 $a(MiAaPQ)EBC2011125 035 $a(Au-PeEL)EBL2011125 035 $a(CaPaEBR)ebr11043766 035 $a(CaONFJC)MIL768015 035 $a(OCoLC)907610126 035 $a(EXLCZ)992670000000608824 100 $a20150507h20152015 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aTRP channels as therapeutic targets $efrom basic science to clinical use /$fedited by Arpad Szallasi ; contributors, M. Allen McAlexander [and fifty-nine others] 210 1$aAmsterdam, [Netherlands] :$cAcademic Press,$d2015. 210 4$dİ2015 215 $a1 online resource (530 p.) 300 $aDescription based upon print version of record. 311 $a0-12-420079-6 311 $a0-12-420024-9 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aFront Cover; TRP Channels as Therapeutic Targets: From Basic Science to Clinical Use; Copyright; Contents; Contributors; Preface; Chapter 1: An Introduction to Transient Receptor Potential Ion Channels and Their Roles in Disease; Discovery and General Properties of TRP Channels; TRP Channels in Normal Physiology; TRP Channels and Sensory Physiology; TRP Channels and Cardiovascular Function; TRP Channels and Gastrointestinal Function; TRP Channels and Urological Function; TRP Channels and the Brain; TRP Channels and Immune Function; TRP Channels and Development; TRP Channels and Disease 327 $aTherapeutic Strategies Based on TRP Channel ModulationAcknowledgment; References; Chapter 2: Transient Receptor Potential Dysfunctions in Hereditary Diseases: TRP Channelopathies and Beyond; Introduction; TRPC Channelopathies; TRPV Channelopathies; TRPM Channelopathies; TRPA Channelopathies; TRPML Channelopathies; TRPP Channelopathies; Conclusions; Acknowledgments; References; Chapter 3: The Role of TRPV1 in Acquired Diseases: Therapeutic Potential of TRPV1 Modulators; Introduction; TRPV1 and Pain; TRPV1 and Gastrointestinal System-Related Disease; TRPV1 and Urinary System-Related Diseases 327 $aTRPV1 and Central Nervous System-Related DiseasesTRPV1 and Respiratory System-Related Diseases; TRPV1 and Cancer; TRPV1 and Cardiovascular System-Related Diseases; TRPV1 and Metabolic Diseases; TRPV1 and Other Disease Conditions; Conclusions; Acknowledgment; References; Chapter 4: TRP Gene Polymorphism and Disease Risk; TRP Gene Polymorphism; TRPA1 ; The TRPC Subfamily; The TRPM Subfamily; The TRPML Subfamily; The TRPV Subfamily; Disease Risk, Clinical Diagnosis, and Personalized Medicine; References; Chapter 5: Use of Topical Capsaicin for Pain Relief; Introduction; Pharmacodynamics 327 $aPharmacokineticsEfficacy and Therapeutic Uses; Postherpetic Neuralgia; HIV -Associated Distal Sensory Polyneuropathy; Other Neuropathic Pain States; Safety and Tolerability; Delivery of Treatment with Capsaicin 8% Patch-Practical Aspects; Application Procedure for the Capsaicin 8% Patch; Postprocedural Instructions for Patients; References; Chapter 6: TRPV1 Agonist Cytotoxicity for Chronic Pain Relief: From Mechanistic Understanding to Clinical Application; Introduction; Mechanisms of TRPV1 Agonist Therapeutic Action; Four Main Determinants of TRPV1 Agonist Actions 327 $aSelectivity of RTX at the Cellular LevelRTX Produces a Prolonged Channel Open Time; TRPV1 Is Selectively Expressed in Subpopulations of DRG Neurons; RTX Is Administered Locally; Companion Dog and Human Studies; Companion (Pet) Dog Models of Chronic Pain; TRPV1 Agonists in the Companion Dog Model of Bone Cancer; TRPV1 Agonists in the Companion Dog Model of Osteoarthritis; Human Studies; References; Chapter 7: Intravesical Capsaicin and Resiniferatoxin for Bladder Disorders; Capsaicin and Resiniferatoxin Targets and Effects in the Urinary Bladder 327 $aThe Rationale for Using Vanilloids to Overcome Lower Urinary Tract Symptoms 606 $aTRP channels 615 0$aTRP channels. 676 $a572.696 702 $aSzallasi$b Arpad$f1958- 702 $aMcAlexander$b M. Allen 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910788295403321 996 $aTRP channels as therapeutic targets$93855532 997 $aUNINA