Systemic lupus erythematosus / / edited by Robert G. Lahita

• Pubblicazione: Amsterdam ; ; Boston, : Elsevier Academic Press, c2004
• Edizione: 4th ed.
• Descrizione fisica: 1 online resource (1376 p.)
• Disciplina: 616.7/72
• Soggetto topico: Systemic lupus erythematosus
• Altri autori: LahitaRobert G <1945-> (Robert George)
• Note generali: Description based upon print version of record.
• Nota di bibliografia: Includes bibliographical references and index.
• Nota di contenuto: Foreword; Preface; Introduction; Section I. Pathogenesis; 1. Autoimmunity and Autoimmune Diseases like Systemic Lupus Erythematosus; The Nature of Autoimmunity; What Leads from Autoimmunity to an Autoimmune State?; Which Diseases Are Really Autoimmune Ones?; Classification of Autoimmune Diseases; The Mosaic of Autoimmunity or Why Are Autoimmune Diseases so Diversified?; The Kaleidoscope of the Autoimmune Mosaic; Why Do Patients Differ from Each Other?; Physiologic and Pathologic Autoimmunity; Mechanisms of Autoimmunity; Breaking Peripheral Tolerance ; Autoimmunity Induction by the Idiotype-Anti-idiotype InteractionRole of Cytokines in the Induction of Autoimmunity; Autoimmunity and MHC: Dissecting the Molecular Basis; Apoptosis and Its Role in Autoimmunity; Using the Principles of Autoimmunity to Design Therapeutics; Modulation of the Idiotypic Network as a Possible Treatment Approach to Autoimmune Diseases; Intravenous Gamma Globulin Infusion; Oral Tolerance; Hemopoietic Stem Cell Transplantation in Autoimmune Diseases; Peptide Immunotherapy; What Are We Expecting in the Future? ; 2. Overview of Cellular Immune Function in Systemic Lupus ErythematosusIntroduction; Monocyte/Macrophage Function; Dendritic Cells; T Lymphocytes; Lymphocyte Numbers; T Lymphocyte CD4 Epitope Deficiency; Functional Features of Anti-T-Cell Antibodies; Activated T Lymphocytes; T Suppressor Lymphocyte Function; T Helper Lymphocyte Function; Double Negative T Cells in SLE; Heat Shock Proteins in Lupus Immune Cell Biology; T-Cell Clones in the Study of the Pathogenesis of Lupus; T-Cell Antigen Receptor Gene Repertoire in SLE; Lymphokines; IL-2; IL-2 Inhibitor; Soluble IL-2 Receptors; IFN-g; IL-6 ; IL-10IL-12; Tumor Necrosis Factor; TGF-b; Other Cytokines; Polarization of the Lymphokine Production Response; Proliferative Responses; Antigens and Mitogens; Alloantigens; Autologous Mixed Lymphocyte Reaction; Skin Tests; Responses to Anti-CD3 Antibody; Biochemical and Molecular Abnormalities of SLE T Cells; Capping of Surface Molecules; Oncogenes in SLE; T-Cell Signaling Abnormalities; Abnormalities of Elf-1 Expression; Mechanisms of Increased TCR/CD3-Mediated [Ca2_]i Response in SLE; FceRIg Chain Replaces the Defective TCR z Chain ; Increased Membrane Lipid Raft Association of theResidual TCR z ChainDeficient Protein Kinase A Activity; Abnormalities in Transcription Factor Expression; Deficient p65-Rel A Subunit of NF-kB in SLE T Cells; Increased CREM Binding to the -180 Site of the IL-2 Promoter; Abnormal Nuclear Translocation of RIIb Subunit; Impaired Protein Translation; Abnormal Immune Cell Signaling and Autoimmunity; Antigen-Presenting Cell Function; Costimulation in Lupus; B7-CD28; CD40-CD40 Ligand; Lymphocyte Trafficking; Cytotoxic Responses; Natural Killer Cells; Specific Cytotoxicity ; Antibody-Dependent Cell-Mediated Cytotoxicity
• Sommario/riassunto: Systemic Lupus Erythematosus, Fourth Edition, provides an understanding of the basic mechanisms as well as the diagnostic and therapeutic aspects of lupus. Four-color illustrations throughout, this book is attractive to both the investigative community and clinicians. As lupus has become a paradigm for the study of autoimmune disease, immunologists investigating autoimmunity are becoming more interested in lupus. Basic immunology of phospholipid antibodies, clotting abnormailities, and newest methods of therapy of antiphospholipid syndrome are given in this newest edition of a classic r
• Titolo autorizzato: Systemic lupus erythematosus
• ISBN: 1-280-96688-2; 9786610966882; 0-08-047454-3
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9910693996903321
• Lo trovi qui: Univ. Federico II