05213nam 2200625 a 450 991069399690332120200520144314.01-280-96688-297866109668820-08-047454-3(CKB)1000000000363888(EBL)288761(OCoLC)469401886(SSID)ssj0000254938(PQKBManifestationID)12087450(PQKBTitleCode)TC0000254938(PQKBWorkID)10211172(PQKB)11704753(MiAaPQ)EBC288761(OCoLC)61397169(EXLCZ)99100000000036388820030523d2004 uy 0engur|n|---|||||txtccrSystemic lupus erythematosus /edited by Robert G. Lahita4th ed.Amsterdam ;Boston Elsevier Academic Pressc20041 online resource (1376 p.)Handout on healthNIH publication ;no. 03-4178Description based upon print version of record.0-12-433901-8 Includes bibliographical references and index.Foreword; Preface; Introduction; Section I. Pathogenesis; 1. Autoimmunity and Autoimmune Diseases like Systemic Lupus Erythematosus; The Nature of Autoimmunity; What Leads from Autoimmunity to an Autoimmune State?; Which Diseases Are Really Autoimmune Ones?; Classification of Autoimmune Diseases; The Mosaic of Autoimmunity or Why Are Autoimmune Diseases so Diversified?; The Kaleidoscope of the Autoimmune Mosaic; Why Do Patients Differ from Each Other?; Physiologic and Pathologic Autoimmunity; Mechanisms of Autoimmunity; Breaking Peripheral ToleranceAutoimmunity Induction by the Idiotype-Anti-idiotype InteractionRole of Cytokines in the Induction of Autoimmunity; Autoimmunity and MHC: Dissecting the Molecular Basis; Apoptosis and Its Role in Autoimmunity; Using the Principles of Autoimmunity to Design Therapeutics; Modulation of the Idiotypic Network as a Possible Treatment Approach to Autoimmune Diseases; Intravenous Gamma Globulin Infusion; Oral Tolerance; Hemopoietic Stem Cell Transplantation in Autoimmune Diseases; Peptide Immunotherapy; What Are We Expecting in the Future?2. Overview of Cellular Immune Function in Systemic Lupus ErythematosusIntroduction; Monocyte/Macrophage Function; Dendritic Cells; T Lymphocytes; Lymphocyte Numbers; T Lymphocyte CD4 Epitope Deficiency; Functional Features of Anti-T-Cell Antibodies; Activated T Lymphocytes; T Suppressor Lymphocyte Function; T Helper Lymphocyte Function; Double Negative T Cells in SLE; Heat Shock Proteins in Lupus Immune Cell Biology; T-Cell Clones in the Study of the Pathogenesis of Lupus; T-Cell Antigen Receptor Gene Repertoire in SLE; Lymphokines; IL-2; IL-2 Inhibitor; Soluble IL-2 Receptors; IFN-g; IL-6IL-10IL-12; Tumor Necrosis Factor; TGF-b; Other Cytokines; Polarization of the Lymphokine Production Response; Proliferative Responses; Antigens and Mitogens; Alloantigens; Autologous Mixed Lymphocyte Reaction; Skin Tests; Responses to Anti-CD3 Antibody; Biochemical and Molecular Abnormalities of SLE T Cells; Capping of Surface Molecules; Oncogenes in SLE; T-Cell Signaling Abnormalities; Abnormalities of Elf-1 Expression; Mechanisms of Increased TCR/CD3-Mediated [Ca2_]i Response in SLE; FceRIg Chain Replaces the Defective TCR z ChainIncreased Membrane Lipid Raft Association of theResidual TCR z ChainDeficient Protein Kinase A Activity; Abnormalities in Transcription Factor Expression; Deficient p65-Rel A Subunit of NF-kB in SLE T Cells; Increased CREM Binding to the -180 Site of the IL-2 Promoter; Abnormal Nuclear Translocation of RIIb Subunit; Impaired Protein Translation; Abnormal Immune Cell Signaling and Autoimmunity; Antigen-Presenting Cell Function; Costimulation in Lupus; B7-CD28; CD40-CD40 Ligand; Lymphocyte Trafficking; Cytotoxic Responses; Natural Killer Cells; Specific CytotoxicityAntibody-Dependent Cell-Mediated CytotoxicitySystemic Lupus Erythematosus, Fourth Edition, provides an understanding of the basic mechanisms as well as the diagnostic and therapeutic aspects of lupus. Four-color illustrations throughout, this book is attractive to both the investigative community and clinicians. As lupus has become a paradigm for the study of autoimmune disease, immunologists investigating autoimmunity are becoming more interested in lupus. Basic immunology of phospholipid antibodies, clotting abnormailities, and newest methods of therapy of antiphospholipid syndrome are given in this newest edition of a classic rSystemic lupus erythematosusSystemic lupus erythematosus.616.7/72Lahita Robert G(Robert George),1945-1352018National Institute of Arthritis and Musculoskeletal and Skin Diseases (U.S.)MiAaPQMiAaPQMiAaPQBOOK9910693996903321Systemic lupus erythematosus3149775UNINA