Anoikis : how the extracellular matrix regulates life-or-death decisions / / edited by Steven M. Frisch

• Pubblicazione: Cham, Switzerland : , : Springer, , [2021]; ©2021
• Descrizione fisica: 1 online resource (210 pages)
• Disciplina: 571.936
• Soggetto topico: Extracellular matrix; Apoptosis; Apoptosi; Histologia
• Soggetto genere / forma: Llibres electrònics
• Persona (resp. second.): FrischSteven Miles
• Nota di contenuto: Intro -- Introduction -- Contents -- 1 Metabolic Contributions to Anoikis-Resistance in Metastatic Dissemination -- Abstract -- 1 Introduction -- 2 Bioenergetics -- 2.1 Glycolysis -- 2.2 Glutaminolysis -- 2.3 Autophagy -- 3 Redox Control -- 3.1 Restricted Glucose Oxidation -- 3.2 Antioxidant Defenses -- 3.3 ROS-Mediated Anti-apoptotic Signaling -- 4 Conclusion -- References -- 2 Metabolic Reprogramming and the Control of Anoikis Resistance in Cancer -- Abstract -- 1 Metabolic Signal Integrators -- 1.1 The PI3K/Akt-mTOR Pathway -- 1.2 The Ras-MAPK Pathway -- 1.3 Myc and HIF-1 Transcription Factors -- 1.4 AMPK Pathway -- 2 ECM Attachment-Dependent Signaling Pathways that Regulate Cell Metabolism -- 3 An Overview of Model Systems Used to Study Anoikis -- 4 Metabolic Adaptations of Detached Cancer Cells-Roles in Anoikis-Resistance and Metastasis -- 4.1 Glucose Metabolism -- 4.2 Amino Acid Metabolism -- 4.3 Redox Homeostasis -- 4.3.1 Antioxidant Enzymes in Anoikis-Resistance -- 4.3.2 Mechanisms to Reduce ROS Generation -- 4.3.3 Synthesis of Reducing Equivalents -- 4.3.4 Mitochondrial ROS and Anoikis -- 4.4 Lipid Metabolism -- 5 HIF-1 and Anoikis-Resistance -- 6 Autophagy and Its Role in the Regulation of Metabolic Stress and Anoikis -- 7 Metabolic Switch in Detached Cells-The Tug of War Between AMPK and Akt -- Acknowledgement -- References -- 3 The Intersection of Anoikis Resistance and Fatty Acid Metabolism in Cancer -- Abstract -- 1 Introduction -- 2 Metabolic Plasticity -- 3 Fatty Acid Oxidation -- 4 Stemness and Fatty Acid Oxidation -- 5 FAO in Ovarian Cancer -- 6 FAO-Mediated Signaling and Anoikis Resistance -- 7 Receptor Tyrosine Kinase Contribution to Metabolic Reprogramming -- 8 Conclusions -- References -- 4 Shc and the Control of Small GTPase Dynamics in Cellular Anchorage -- Abstract. ; 1 Cellular Anchorage and the Importance of Shape Change -- 2 Regulation of Shape Change by Rho GTPases -- 3 Rho GTPases and Abnormal Matrix Signaling in Cancer -- 4 p52Shc and the Control of Mechanical Signals -- 5 Distinct Functional Roles for p66Shc -- 6 Control of RhoA and Anoikis by p66Shc -- 7 p66Shc and Metastatic Behavior -- 8 Epigenetic Control of SHC1 and Implications for Lineage Shifting -- 9 Summary -- References -- 5 Anoikis and the Human Gut Epithelium in Health and Disease -- Abstract -- 1 Anoikis: Back to (General) Basics -- 1.1 A Brief Word on Apoptosis -- 1.2 Cell-ECM and Cell-Cell Interactions -- 1.2.1 Integrins -- 1.2.2 E-cadherin -- 1.3 Enter Anoikis -- 1.3.1 Anoikis and Integrins -- 1.3.2 Anoikis and E-cadherin -- 2 Anoikis and the Human Gut Epithelium in Health -- 2.1 Anoikis and the Renewal of the Human Gut Epithelium -- 2.1.1 A Few Words on the Regulation of hIEC Survival -- 2.1.2 hIEC Anoikis: Sensitivity Versus State of Differentiation -- 2.2 hIEC Anoikis and Integrins -- 2.3 hIEC Anoikis and E-cadherin -- 3 Anoikis and the Human Gut Epithelium in Disease -- 3.1 Anoikis and CRC: Generalities -- 3.1.1 Anoikis, Integrins and CRC -- 3.1.2 Anoikis, E-cadherins and CRC -- 3.2 Anoikis and ... IBD? -- 4 Concluding Considerations -- Acknowledgements -- References -- 6 The Roles of Anoikis in Cervical Cancer -- Abstract -- 1 Introduction -- 2 The Role of Anoikis in Cervical Cancer -- 2.1 Molecular Mechanisms of Anoikis -- 2.2 The Role of Anoikis Resistance in Cervical Cancer Invasion and Metastasis -- 2.3 Molecular Mechanisms of Anoikis Resistance in Cervical Cancer Cells -- 2.4 The Role of Chronic Stress in Cervical Cancer Through Anoikis Resistance -- 3 The Role of YAP Proteins in Cervical Cancer -- 3.1 The Structure and Function of YAP-Related Proteins -- 3.2 Role of YAP Proteins in Cervical Caner. ; 3.3 YAP Proteins in the Susceptibility to hrHPV Infection -- 3.4 The Role of Chronic Stress in Cervical Cancer Through the Hippo-YAP Pathway -- 4 Conclusions and Future Directions -- References -- 7 Anoikis Resistance in Melanoma -- Abstract -- 1 Introduction -- 2 Epithelial-Mesenchymal Transition (EMT) -- 3 Anoikis-Death Induced in Epithelial Cells upon Detachment from Extra Cellular Matrix (ECM) -- 4 General Pathways Leading to Anoikis Resistance in Epithelial Tissues -- 5 Melanocytes and Melanoma-Non-epithelial Lineage Origins -- 6 Cell Surface Molecules in Anoikis Resistance in Melanoma -- 6.1 Integrin Switch -- 6.2 Fibronectin -- 6.3 Cadherins -- 7 Activation of Receptor Tyrosine Kinases in Melanoma Anoikis Resistance -- 7.1 c-MET/HGF Axis -- 7.2 FGFR1/FGF2 Axis -- 8 Signaling Pathways in Melanoma Anoikis Resistance -- 8.1 Mitogen-Activated Protein Kinase (MAPK) Pathway -- 8.2 Phosphoinositide 3-Kinase (PI3K)/AKT Pathway -- 8.3 CDKN2A and p16INK4A -- 8.4 Focal Adhesion Kinase (FAK) Pathway -- 9 Transcription Factors in Melanoma Anoikis Resistance -- 9.1 STAT3 -- 9.2 FOSL1 -- 9.3 BRN2 -- 10 Anti-apoptotic Mechanisms in Melanoma Anoikis Resistance -- 11 Conclusion -- References -- 8 Anoikis Mediated by Stress-Activated MAPK Signaling Pathways -- Abstract -- 1 Stress-Activated MAPK Signaling Pathways -- 1.1 p38 MAPK -- 1.2 JNK -- 2 Stress-Activated MAPK and Cell Death -- 3 Stress-Activated MAPK and BCL2 Family Proteins -- 4 JNK and Anoikis -- 5 p38 MAPK and Anoikis -- 6 Conclusions -- References -- 9 The TGFβ and Androgen Receptor Signaling Pathways Converge to Support Anoikis Resistance in Triple Negative Breast Cancer -- Abstract -- 1 Introduction -- 2 Anoikis Resistance and Breast Cancer -- 3 The TGFβ Pathway -- 4 TGFβ Signaling in Breast Cancer -- 5 TGFβ Inhibitors in BC Clinical Trials. ; 6 Connections Between AR and TGFβ in Prostate and Breast Cancer -- 7 TGFβ and AR Pathways Converge to Support TNBC Anoikis Resistance -- References -- 10 Regulation of Homeostasis and Anoikis by Epithelial Cell Extrusion -- Abstract -- 1 Introduction -- 2 Sphingosine-1-Phosphate (S1P) and Collaborating Factors in Cell Extrusion -- 3 Specialized Mechanisms Pertaining to the Extrusion of Transformed Cells -- 4 Summary and Future Directions -- References.
• Titolo autorizzato: Anoikis
• ISBN: 3-030-73856-6
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9910495350303321
• Lo trovi qui: Univ. Federico II