LEADER 07315nam 2200517 450 001 9910495350303321 005 20230522150112.0 010 $a3-030-73856-6 035 $a(CKB)4100000011990527 035 $a(MiAaPQ)EBC6684860 035 $a(Au-PeEL)EBL6684860 035 $a(PPN)260305642 035 $a(EXLCZ)994100000011990527 100 $a20220414d2021 uy 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aAnoikis $ehow the extracellular matrix regulates life-or-death decisions /$fedited by Steven M. Frisch 210 1$aCham, Switzerland :$cSpringer,$d[2021] 210 4$d©2021 215 $a1 online resource (210 pages) 311 $a3-030-73854-X 327 $aIntro -- Introduction -- Contents -- 1 Metabolic Contributions to Anoikis-Resistance in Metastatic Dissemination -- Abstract -- 1 Introduction -- 2 Bioenergetics -- 2.1 Glycolysis -- 2.2 Glutaminolysis -- 2.3 Autophagy -- 3 Redox Control -- 3.1 Restricted Glucose Oxidation -- 3.2 Antioxidant Defenses -- 3.3 ROS-Mediated Anti-apoptotic Signaling -- 4 Conclusion -- References -- 2 Metabolic Reprogramming and the Control of Anoikis Resistance in Cancer -- Abstract -- 1 Metabolic Signal Integrators -- 1.1 The PI3K/Akt-mTOR Pathway -- 1.2 The Ras-MAPK Pathway -- 1.3 Myc and HIF-1 Transcription Factors -- 1.4 AMPK Pathway -- 2 ECM Attachment-Dependent Signaling Pathways that Regulate Cell Metabolism -- 3 An Overview of Model Systems Used to Study Anoikis -- 4 Metabolic Adaptations of Detached Cancer Cells-Roles in Anoikis-Resistance and Metastasis -- 4.1 Glucose Metabolism -- 4.2 Amino Acid Metabolism -- 4.3 Redox Homeostasis -- 4.3.1 Antioxidant Enzymes in Anoikis-Resistance -- 4.3.2 Mechanisms to Reduce ROS Generation -- 4.3.3 Synthesis of Reducing Equivalents -- 4.3.4 Mitochondrial ROS and Anoikis -- 4.4 Lipid Metabolism -- 5 HIF-1 and Anoikis-Resistance -- 6 Autophagy and Its Role in the Regulation of Metabolic Stress and Anoikis -- 7 Metabolic Switch in Detached Cells-The Tug of War Between AMPK and Akt -- Acknowledgement -- References -- 3 The Intersection of Anoikis Resistance and Fatty Acid Metabolism in Cancer -- Abstract -- 1 Introduction -- 2 Metabolic Plasticity -- 3 Fatty Acid Oxidation -- 4 Stemness and Fatty Acid Oxidation -- 5 FAO in Ovarian Cancer -- 6 FAO-Mediated Signaling and Anoikis Resistance -- 7 Receptor Tyrosine Kinase Contribution to Metabolic Reprogramming -- 8 Conclusions -- References -- 4 Shc and the Control of Small GTPase Dynamics in Cellular Anchorage -- Abstract. 327 $a1 Cellular Anchorage and the Importance of Shape Change -- 2 Regulation of Shape Change by Rho GTPases -- 3 Rho GTPases and Abnormal Matrix Signaling in Cancer -- 4 p52Shc and the Control of Mechanical Signals -- 5 Distinct Functional Roles for p66Shc -- 6 Control of RhoA and Anoikis by p66Shc -- 7 p66Shc and Metastatic Behavior -- 8 Epigenetic Control of SHC1 and Implications for Lineage Shifting -- 9 Summary -- References -- 5 Anoikis and the Human Gut Epithelium in Health and Disease -- Abstract -- 1 Anoikis: Back to (General) Basics -- 1.1 A Brief Word on Apoptosis -- 1.2 Cell-ECM and Cell-Cell Interactions -- 1.2.1 Integrins -- 1.2.2 E-cadherin -- 1.3 Enter Anoikis -- 1.3.1 Anoikis and Integrins -- 1.3.2 Anoikis and E-cadherin -- 2 Anoikis and the Human Gut Epithelium in Health -- 2.1 Anoikis and the Renewal of the Human Gut Epithelium -- 2.1.1 A Few Words on the Regulation of hIEC Survival -- 2.1.2 hIEC Anoikis: Sensitivity Versus State of Differentiation -- 2.2 hIEC Anoikis and Integrins -- 2.3 hIEC Anoikis and E-cadherin -- 3 Anoikis and the Human Gut Epithelium in Disease -- 3.1 Anoikis and CRC: Generalities -- 3.1.1 Anoikis, Integrins and CRC -- 3.1.2 Anoikis, E-cadherins and CRC -- 3.2 Anoikis and ... IBD? -- 4 Concluding Considerations -- Acknowledgements -- References -- 6 The Roles of Anoikis in Cervical Cancer -- Abstract -- 1 Introduction -- 2 The Role of Anoikis in Cervical Cancer -- 2.1 Molecular Mechanisms of Anoikis -- 2.2 The Role of Anoikis Resistance in Cervical Cancer Invasion and Metastasis -- 2.3 Molecular Mechanisms of Anoikis Resistance in Cervical Cancer Cells -- 2.4 The Role of Chronic Stress in Cervical Cancer Through Anoikis Resistance -- 3 The Role of YAP Proteins in Cervical Cancer -- 3.1 The Structure and Function of YAP-Related Proteins -- 3.2 Role of YAP Proteins in Cervical Caner. 327 $a3.3 YAP Proteins in the Susceptibility to hrHPV Infection -- 3.4 The Role of Chronic Stress in Cervical Cancer Through the Hippo-YAP Pathway -- 4 Conclusions and Future Directions -- References -- 7 Anoikis Resistance in Melanoma -- Abstract -- 1 Introduction -- 2 Epithelial-Mesenchymal Transition (EMT) -- 3 Anoikis-Death Induced in Epithelial Cells upon Detachment from Extra Cellular Matrix (ECM) -- 4 General Pathways Leading to Anoikis Resistance in Epithelial Tissues -- 5 Melanocytes and Melanoma-Non-epithelial Lineage Origins -- 6 Cell Surface Molecules in Anoikis Resistance in Melanoma -- 6.1 Integrin Switch -- 6.2 Fibronectin -- 6.3 Cadherins -- 7 Activation of Receptor Tyrosine Kinases in Melanoma Anoikis Resistance -- 7.1 c-MET/HGF Axis -- 7.2 FGFR1/FGF2 Axis -- 8 Signaling Pathways in Melanoma Anoikis Resistance -- 8.1 Mitogen-Activated Protein Kinase (MAPK) Pathway -- 8.2 Phosphoinositide 3-Kinase (PI3K)/AKT Pathway -- 8.3 CDKN2A and p16INK4A -- 8.4 Focal Adhesion Kinase (FAK) Pathway -- 9 Transcription Factors in Melanoma Anoikis Resistance -- 9.1 STAT3 -- 9.2 FOSL1 -- 9.3 BRN2 -- 10 Anti-apoptotic Mechanisms in Melanoma Anoikis Resistance -- 11 Conclusion -- References -- 8 Anoikis Mediated by Stress-Activated MAPK Signaling Pathways -- Abstract -- 1 Stress-Activated MAPK Signaling Pathways -- 1.1 p38 MAPK -- 1.2 JNK -- 2 Stress-Activated MAPK and Cell Death -- 3 Stress-Activated MAPK and BCL2 Family Proteins -- 4 JNK and Anoikis -- 5 p38 MAPK and Anoikis -- 6 Conclusions -- References -- 9 The TGF? and Androgen Receptor Signaling Pathways Converge to Support Anoikis Resistance in Triple Negative Breast Cancer -- Abstract -- 1 Introduction -- 2 Anoikis Resistance and Breast Cancer -- 3 The TGF? Pathway -- 4 TGF? Signaling in Breast Cancer -- 5 TGF? Inhibitors in BC Clinical Trials. 327 $a6 Connections Between AR and TGF? in Prostate and Breast Cancer -- 7 TGF? and AR Pathways Converge to Support TNBC Anoikis Resistance -- References -- 10 Regulation of Homeostasis and Anoikis by Epithelial Cell Extrusion -- Abstract -- 1 Introduction -- 2 Sphingosine-1-Phosphate (S1P) and Collaborating Factors in Cell Extrusion -- 3 Specialized Mechanisms Pertaining to the Extrusion of Transformed Cells -- 4 Summary and Future Directions -- References. 606 $aExtracellular matrix 606 $aApoptosis 606 $aApoptosi$2thub 606 $aHistologia$2thub 608 $aLlibres electrònics$2thub 615 0$aExtracellular matrix. 615 0$aApoptosis. 615 7$aApoptosi 615 7$aHistologia 676 $a571.936 702 $aFrisch$b Steven Miles 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910495350303321 996 $aAnoikis$92066373 997 $aUNINA LEADER 04265nam 22011293u 450 001 9910792102403321 005 20210119232916.0 010 $a1-4422-4960-9 010 $a1-4422-4961-7 035 $a(CKB)2560000000365785 035 $a(EBL)2081425 035 $a(OCoLC)913377692 035 $a(SSID)ssj0001515568 035 $a(PQKBManifestationID)12536049 035 $a(PQKBTitleCode)TC0001515568 035 $a(PQKBWorkID)11482275 035 $a(PQKB)11402024 035 $a(MiAaPQ)EBC2081425 035 $a(PPN)204764912 035 $a(EXLCZ)992560000000365785 100 $a20151005d2015|||| u|| | 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aPolitics of Autism$b[electronic resource] $eNavigating The Contested Spectrum 210 $cRowman & Littlefield Publishers$d2015 215 $a1 online resource (191 p.) 300 $aDescription based upon print version of record. 327 $a""Contents""; ""Preface""; ""1 Introduction""; ""2 A Short History of Autism""; ""3 Medicine, Science, and Math""; ""4 Education""; ""5 Before, Outside, and After the Classroom""; ""6 The Future""; ""Appendix: A Timeline of Autism Policy and Politics""; ""Notes""; ""Index""; ""About the Author"" 330 $aIn the first book devoted exclusively to the contentious politics of autism, noted political scientist and public policy expert John J. Pitney, Jr., explains how autism has evolved into a heated political issue disputed by scientists, educators, social workers, and families. Nearly everything about autism is subject to debate and struggle, including its measurement and definition. Organizational attempts to deal with autism have resulted in not a single "autism policy," but a vast array of policies at the federal, state, and local levels, which often leave people with autism and their families 606 $aAutistic disorder -- United States 606 $aEducation, Special -- United States 606 $aPolicy Making -- United States 606 $aPolitics -- United States 606 $aSocial Control, Formal 606 $aSocial Control Policies 606 $aEducation, Nonprofessional 606 $aChild Development Disorders, Pervasive 606 $aSocial Sciences 606 $aPolicy 606 $aHealth Care Economics and Organizations 606 $aEducation 606 $aMental Disorders Diagnosed in Childhood 606 $aSociology 606 $aHealth Care 606 $aMental Disorders 606 $aGeography 606 $aPsychology 606 $aPublic Policy 606 $aAutistic Disorder 606 $aEducation, Special 606 $aPolicy Making 606 $aPolitics 606 $aPsychiatry$2HILCC 606 $aHealth & Biological Sciences$2HILCC 606 $aPsychiatric Disorders, Individual$2HILCC 607 $aNorth America 607 $aAmericas 607 $aGeographic Locations 607 $aUnited States 615 4$aAutistic disorder -- United States. 615 4$aEducation, Special -- United States. 615 4$aPolicy Making -- United States. 615 4$aPolitics -- United States. 615 2$aSocial Control, Formal 615 2$aSocial Control Policies 615 2$aEducation, Nonprofessional 615 2$aChild Development Disorders, Pervasive 615 2$aSocial Sciences 615 2$aPolicy 615 2$aHealth Care Economics and Organizations 615 2$aEducation 615 2$aMental Disorders Diagnosed in Childhood 615 2$aSociology 615 2$aHealth Care 615 2$aMental Disorders 615 2$aGeography 615 2$aPsychology 615 2$aPublic Policy 615 2$aAutistic Disorder 615 2$aEducation, Special 615 2$aPolicy Making 615 2$aPolitics 615 7$aPsychiatry 615 7$aHealth & Biological Sciences 615 7$aPsychiatric Disorders, Individual 676 $a618.9285 700 $aPitney$b John J.$cJr.,$f1955-$01470521 801 0$bAU-PeEL 801 1$bAU-PeEL 801 2$bAU-PeEL 906 $aBOOK 912 $a9910792102403321 996 $aPolitics of Autism$93682447 997 $aUNINA LEADER 03872oam 2200697I 450 001 9910792578003321 005 20230808200632.0 010 $a1-4094-2399-9 010 $a1-317-06639-1 010 $a9786612892752 010 $a1-315-60531-7 010 $a1-282-89275-4 010 $a1-4094-0024-7 024 7 $a10.4324/9781315605319 035 $a(CKB)3710000000964642 035 $a(MiAaPQ)EBC4456104 035 $a(MiAaPQ)EBC605123 035 $a(Au-PeEL)EBL4456104 035 $a(CaPaEBR)ebr11463608 035 $a(CaONFJC)MIL975466 035 $a(OCoLC)1011163380 035 $a(OCoLC)948604952 035 $a(EXLCZ)993710000000964642 100 $a20180706e20162010 uy 0 101 0 $aeng 135 $aurcnu|||||||| 181 $2rdacontent 182 $2rdamedia 183 $2rdacarrier 200 00$aRenaissance theories of vision /$fedited by John Shannon Hendrix and Charles H. Carman 210 1$aLondon ;$aNew York :$cRoutledge,$d2016. 215 $a1 online resource (258 pages) $cillustrations 225 1 $aVisual Culture in Early Modernity 300 $a"An Ashgate book"--Cover. 300 $aFirst published 2010 by Ashgate Publishing. 311 $a1-4094-8651-6 311 $a1-317-06640-5 320 $aIncludes bibliographical references and index. 327 $aIntroduction / John S. Hendrix and Charles H. Carman -- Classical optics and the perspectivae traditions leading to the Renaissance / Nader El-Bizri -- Meanings of perspective in the Renaissance : tensions and resolution / Charles Carman -- Criminal vision in early modern Florence : Fra Angelico's altarpiece for "Il Tempio" and the Magdalenian gaze / Allie Terry -- Donatello's Chellini Madonna, light, and vision / Amy R. Bloch -- Perception as a function of desire in the Renaissance / John Hendrix -- Leonardo da Vinci's theory of vision and creativity : the Uffizi Annunciation / Liana De Girolami Cheney -- At the boundaries of sight : the Italian Renaissance cloud putto / Christian Kleinbub -- Gesture and perspective in Raphael's School of Athens / Nicholas Temple -- Seeing and the transfer of spirits in early modern art theory / Thijs Weststeijn -- "All in him selfe as in a glass he sees" : mirrors and vision in the Renaissance / Faye Tudor -- "Nearest the tangible earth" : Rembrandt, Samuel van Hoogstraten, George Berkeley, and the optics of touch / Alice Crawford Berghof. 330 8 $aHow are processes of vision, perception, and sensation conceived in the Renaissance? How are those conceptions made manifest in the arts? The essays in this volume address these and similar questions to establish important theoretical and philosophical bases for artistic production in the Renaissance and beyond. The essays also attend to the views of historically significant writers from the ancient classical period to the eighteenth century, including Plato, Aristotle, Plotinus, St Augustine, Ibn Sina (Avicenna), Ibn al-Haytham (Alhazen), Ibn Sahl, Marsilio Ficino, Nicholas of Cusa, Leon Battista Alberti, Gian Paolo Lomazzo, Gregorio Comanini, John Davies, Rene Descartes, Samuel van Hoogstraten, and George Berkeley. 410 0$aVisual culture in early modernity. 606 $aVisual perception$xHistory 606 $aVision$xHistory 606 $aPerspective$xHistory 606 $aArt$xPhilosophy 606 $aArt, Renaissance 615 0$aVisual perception$xHistory. 615 0$aVision$xHistory. 615 0$aPerspective$xHistory. 615 0$aArt$xPhilosophy. 615 0$aArt, Renaissance. 676 $a701.8 701 $aCarman$b Charles H$0777391 701 $aHendrix$b John$0899828 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910792578003321 996 $aRenaissance theories of vision$93741119 997 $aUNINA